Hippocampal Long-Term Potentiation Is Supported by Presynaptic and Postsynaptic Tyrosine Receptor Kinase B-Mediated Phospholipase Cγ Signaling

Autor: Carla Sciarretta, Tobias Bonhoeffer, Martin Korte, Liliana Minichiello, Annette Gärtner, Dorit G Polnau, Hans Thoenen, Volker Staiger

Publikováno v: Gärtner, A, Polnau, D G, Staiger, V, Sciarretta, C, Minichiello, L, Thoenen, H, Bonhoeffer, T & Korte, M 2006, ' Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling ', Journal of Neuroscience, vol. 26, no. 13, pp. 3496-504 . https://doi.org/10.1523/JNEUROSCI.3792-05.2006

Neurotrophins have been shown to play a critical role in activity-dependent synaptic plasticity such as long-term potentiation (LTP) in the hippocampus. Although the role of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor [t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa5c8251c4a9fda4c43210839be958b
https://doi.org/10.1523/jneurosci.3792-05.2006

Ultrastructural Identification of Storage Compartments and Localization of Activity-Dependent Secretion of Neurotrophin 6 in Hippocampal Neurons

Autor: Yuri Shostak, Annette Gärtner, Natalie Hackel, Hans Thoenen, Iryna M. Ethell

Publikováno v: Molecular and Cellular Neuroscience. 15:215-234

A modulatory role of neurotrophins (NTs) in activity-dependent neuronal plasticity by pre- and postsynaptic mechanisms is now well established. In this context, it is important to identify the storage compartments and to localize the precise site(s)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012a07928e05bbaa28be48a58de2e699
https://doi.org/10.1006/mcne.1999.0825

A role for BDNF in mechanosensation

Autor: Klaus V. Toyka, Patrick Carroll, Gary R. Lewin, Hans Thoenen, Martin Koltzenburg

Publikováno v: Scopus-Elsevier

Brain-derived neurotrophic factor (BDNF) is a survival factor for certain sensory neurons during development. Using electrophysiology in BDNF-deficient mice, we show here that slowly adapting mechanoreceptors (SAM), but not other types of cutaneous a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0729d99f9bff11106ff1733805af80
https://doi.org/10.1038/242

Reduced Size of Retinal Ganglion Cell Axons and Hypomyelination in Mice Lacking Brain-Derived Neurotrophic Factor

Autor: Alessandro Cellerino, Yves-Alain Barde, Patrick Carroll, Hans Thoenen

Publikováno v: Molecular and Cellular Neuroscience. 9:397-408

While brain-derived neurotrophic factor (BDNF) delays the death of axotomized retinal ganglion cells in rodents, it is unclear if it affects any aspect of the normal development of these cells. Here we examined the optic nerve of bdnf-/- mice. Axonal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c81357c615101f349fad8fbcf8d9b6
https://doi.org/10.1006/mcne.1997.0641

Inactivation of bcl-2 Results in Progressive Degeneration of Motoneurons, Sympathetic and Sensory Neurons during Early Postnatal Development

Autor: Michael Meyer, Theologos M. Michaelidis, Jonathan D. Cooper, Michael Sendtner, Matti S. Airaksinen, Bettina Holtmann, Hans Thoenen

Publikováno v: University of Helsinki

Bcl-2 is a major regulator of programmed cell death, a critical process in shaping the developing nervous system. To assess whether Bcl-2 is involved in regulating neuronal survival and in mediating the neuroprotective action of neurotrophic factors,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08d90c674a7c2510960b2a323f2e1a3