Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hans Stauss"'
Autor:
Joana B. Neves, Kirsty Roberts, Janani Sivakumaran Nguyen, Soha El Sheikh, My-Anh Tran-Dang, Catherine Horsfield, Faiz Mumtaz, Peter Campbell, Hans Stauss, Maxine G.B. Tran, Thomas Mitchell
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105389- (2022)
Summary: Succinate dehydrogenase (SDH)-deficient renal cell carcinoma represents a rare subtype of hereditary kidney cancer. Clinical diagnosis can be challenging and there is little evidence to guide systemic therapeutic options. We performed genomi
Externí odkaz:
https://doaj.org/article/7c2a642387f14ba6a5d5277245cb9417
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 161-171 (2020)
Recent clinical trials are evaluating induced pluripotent stem cells (iPSCs) as a cellular therapy in the field of regenerative medicine. The widespread clinical utility of iPSCs is expected to be realized using allogeneic cells that have undergone t
Externí odkaz:
https://doaj.org/article/5c6b92241d164d1ba0830acfadee358e
Autor:
Bithi Chatterjee, Yun Deng, Angelika Holler, Nicolas Nunez, Tarik Azzi, Liliana Danusia Vanoaica, Anne Müller, Hana Zdimerova, Olga Antsiferova, Andrea Zbinden, Riccarda Capaul, Johannes H Dreyer, David Nadal, Burkhard Becher, Mark D Robinson, Hans Stauss, Christian Münz
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007748 (2019)
Epstein Barr virus (EBV) is one of the most ubiquitous human pathogens in the world, persistently infecting more than 90% of the adult human population. It drives some of the strongest human CD8+ T cell responses, which can be observed during symptom
Externí odkaz:
https://doaj.org/article/1c51aad6aa5f4c7680263e91d52a806d
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
A single nucleotide polymorphism, C1858T, in the gene encoding the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) results in one of the strongest genetic traits associated with autoimmune disease outside of the Major Histocompatibility Com
Externí odkaz:
https://doaj.org/article/2db781b84c644e24a1c0fe123631fa0e
Autor:
Anne-Christine Field, Conrad Vink, Richard Gabriel, Roua Al-Subki, Manfred Schmidt, Nicholas Goulden, Hans Stauss, Adrian Thrasher, Emma Morris, Waseem Qasim
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68201 (2013)
Transfer of tumour antigen-specific receptors to T cells requires efficient delivery and integration of transgenes, and currently most clinical studies are using gamma retroviral or lentiviral systems. Whilst important proof-of-principle data has bee
Externí odkaz:
https://doaj.org/article/3ac31bb6c4464dc593cbe62cdfbb9aea
Autor:
Sarene Koh, Noriko Shimasaki, Rossarin Suwanarusk, Zi Zong Ho, Adeline Chia, Nasirah Banu, Shanshan Wu Howland, Alice Soh Meoy Ong, Adam J Gehring, Hans Stauss, Laurent Renia, Matti Sällberg, Dario Campana, Antonio Bertoletti
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Hepatocellular carcinoma (HCC) cells often have hepatitis B virus (HBV)-DNA integration and can be targeted by HBV-specific T cells. The use of viral vectors to introduce exogenous HBV-specific T-cell receptors (TCR) on T cells to redirect their spec
Externí odkaz:
https://doaj.org/article/e9fd7843759f49c69a0b5008cd80134b
Publikováno v:
Advances in Hematology, Vol 2012 (2012)
Adoptive immunotherapy using TCR gene modified T cells may allow separation of beneficial Graft versus tumour responses from harmful GvHD. Improvements to this include methods to generate high avidity or high affinity TCR, improvements in vector desi
Externí odkaz:
https://doaj.org/article/ea8270d6a2c8448eb1dbafdbbefc859e
Autor:
Cristina Cellerai, Alexandre Harari, Hans Stauss, Sabine Yerly, Anna-Maria Geretti, Anne Carroll, Thynn Yee, Jonathan Ainsworth, Ian Williams, John Sweeney, Andrew Freedman, Margaret Johnson, Giuseppe Pantaleo, Sabine Kinloch-de Loes
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18164 (2011)
BackgroundIntervention with antiretroviral treatment (ART) and control of viral replication at the time of HIV-1 seroconversion may curtail cumulative immunological damage. We have therefore hypothesized that ART maintenance over a very prolonged per
Externí odkaz:
https://doaj.org/article/b262d415a2514fc4899f27eac687b659
Autor:
Ronjon Chakraverty, Hans Stauss, Martin Pule, Bernhard Schiedlmeier, Lei Zhang, Pedro Santos e Sousa, Rebecca Pike, Teresa Manzo, Angelika Holler, Sian Henson, Mathias Zech, Pedro Veliça
Supplementary methods for flow cytometry and retroviral construct generation. Supplementary Figure 1. Expression of activated caspase-3 in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure 2. Expression of CD25 and CD69 in CD8+ T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc86460510f3b231fc2cbbccfdfb81f
https://doi.org/10.1158/0008-5472.22405631.v1
https://doi.org/10.1158/0008-5472.22405631.v1
Autor:
Emmanuel Donnadieu, Maik Luu, Miriam Alb, Brigitte Anliker, Silvia Arcangeli, Chiara Bonini, Biagio De Angelis, Rashmi Choudhary, David Espie, Anne Galy, Cam Holland, Zoltán Ivics, Chahrazade Kantari-Mimoun, Marie Jose Kersten, Ulrike Köhl, Chantal Kuhn, Bruno Laugel, Franco Locatelli, Ibtissam Marchiq, Janet Markman, Marta Angiola Moresco, Emma Morris, Helene Negre, Concetta Quintarelli, Michael Rade, Kristin Reiche, Matthias Renner, Eliana Ruggiero, Carmen Sanges, Hans Stauss, Maria Themeli, Jan Van den Brulle, Michael Hudecek, Monica Casucci
Publikováno v:
Donnadieu, E, Luu, M, Alb, M, Anliker, B, Arcangeli, S, Bonini, C, de Angelis, B, Choudhary, R, Espie, D, Galy, A, Holland, C, Ivics, Z, Kantari-Mimoun, C, Kersten, M J, Köhl, U, Kuhn, C, Laugel, B, Locatelli, F, Marchiq, I, Markman, J, Moresco, M A, Morris, E, Negre, H, Quintarelli, C, Rade, M, Reiche, K, Renner, M, Ruggiero, E, Sanges, C, Stauss, H, Themeli, M, van den Brulle, J, Hudecek, M & Casucci, M 2022, ' Time to evolve : predicting engineered T cell-associated toxicity with next-generation models ', Journal for Immunotherapy of Cancer, vol. 10, no. 5 . https://doi.org/10.1136/jitc-2021-003486
Despite promising clinical results in a small subset of malignancies, therapies based on engineered chimeric antigen receptor and T-cell receptor T cells are associated with serious adverse events, including cytokine release syndrome and neurotoxicit