Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Hans Schick"'
Publikováno v:
The Journal of organic chemistry. 64(14)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd9b2dfcbed66912bb6f745394689a75
https://pubmed.ncbi.nlm.nih.gov/34237860
https://pubmed.ncbi.nlm.nih.gov/34237860
Autor:
Sven Frormann, B.Y. Kögel, Bernd Sundermann, Klaus Linz, Achim Kless, Helmut Sonnenschein, Wolfgang P. Schröder, Stefan Schunk, Werner Englberger, Derek Saunders, Hans Schick, Tieno Germann, Saskia Zemolka, Thomas Christoph, Claudia Hinze, Stefan Oberbörsch, Stephanie Harlfinger
Publikováno v:
ACS Medicinal Chemistry Letters. 5:857-862
In a previous communication, our efforts leading from 1 to the identification of spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amine 2a as analgesic NOP and opioid receptor agonist were disclosed and their favorable in vitro and in vivo pharmacologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fbb1f07a0eb7a8eeee56a55aa18175
https://doi.org/10.1021/ml500117c
https://doi.org/10.1021/ml500117c
Autor:
Tieno Germann, Bernd Sundermann, Sven Frormann, Helmut Sonnenschein, Hans Schick, Werner Englberger, B.Y. Kögel, Derek Saunders, Achim Kless, Klaus Linz, Stefan Oberbörsch, Stephanie Harlfinger, Saskia Zemolka, Thomas Christoph, Claudia Hinze, Wolfgang P. Schröder, Stefan Schunk
Publikováno v:
ACS Medicinal Chemistry Letters. 5:851-856
We report the discovery of spiro[cyclohexane-pyrano[3,4-b]indole]-amines, as functional nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonists with strong efficacy in preclinical models of acute and neuropathic pain. Utilizing 4-(dimethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fe90b0366ab101fe23bc576f011c77
https://doi.org/10.1021/ml500116x
https://doi.org/10.1021/ml500116x
Publikováno v:
Liebigs Annalen. 1996:881-885
Benzotriazolides 1 of alkanoic acids with one hydrogen atom in α-position to the carboxamide group can be deprotonated with lithium diisopropylamide or lithium hexamethyldisilazanide to amide enolates 2 which condense at −90 to −95°C with keton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff778858f2256d4fc3198b29d18cdfbd
https://doi.org/10.1002/jlac.199619960604
https://doi.org/10.1002/jlac.199619960604
Publikováno v:
Liebigs Annalen. 1996:1443-1448
The enzyme-catalyzed regio- and enantioselective alcoholysis of racemic cis- and trans-2,3-dimethylpentanedioc anhydride in the presence of Novozym 435 from Candida antarctica afforded two of the eight possible monoesters with an enantiomeric excess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81290b33602984a787b7be2a05780b25
https://doi.org/10.1002/jlac.199619960916
https://doi.org/10.1002/jlac.199619960916
Publikováno v:
Angewandte Chemie. 117:7985-8014
Bei der Benennung von Naturstoffen gab es, hauptsachlich aus historischen Grunden, viele Unklarheiten. Zu Beginn der Naturstoffchemie lag zwischen der Isolierung einer neuen Substanz und ihrer Charakterisierung ein langerer Zeitraum. Daher erhielten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1a68442abfb9fd0062bb03503d2ff69
https://doi.org/10.1002/ange.200503353
https://doi.org/10.1002/ange.200503353
Autor:
Benjamin Bader, Philip Lienau, Gerhard Siemeister, Gesa Deeg, Dominik Mumberg, Hans Schick, Ulrich Luecking, Hans Briem, Michael Brands, Karl Ziegelbauer, Franz von Nussbaum, Lars Wortmann, Julien Lefranc, Christoph Schatz, Antje Margret Wengner
Publikováno v:
Cancer Research. 77:983-983
The integrity of the genome of eukaryotic cells is secured by complex signaling pathways, known as DNA damage response (DDR). Recognition of DNA damage activates DDR pathways resulting in cell cycle arrest, suppression of general translation, inducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0287e16653dd936ab69c67c6759da79
https://doi.org/10.1158/1538-7445.am2017-983
https://doi.org/10.1158/1538-7445.am2017-983
Autor:
Richard Prousa, Eberhard Schrötter, Manuela Dubs, Ina Scherlitz-Hofmann, Hans Schick, Peter Droescher, Bruno Schönecker
Publikováno v:
Synthesis. 1999:1331-1334
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::523a94229a5e1afbcd6d66b3261021ba
https://doi.org/10.1055/s-1999-3547
https://doi.org/10.1055/s-1999-3547
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1963-1968
α-Chlorinated β-lactones are obtained in a one-step reaction at a temperature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede937f0bcbbc1d8a8a370f2ccacca6b
https://doi.org/10.1039/a700805h
https://doi.org/10.1039/a700805h
Publikováno v:
Pure and Applied Chemistry. 69:605-608
Ester enolates derived from alkyl esters of alkanoic acids react with car- bony1 compounds in an aldol type reaction forming alkyl @-hydroxyalkanoates. The substitution of an alkyl ester by the corresponding phenyl ester causes the formation of @-lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2218911b318811fd1cbf1d9fbe1c3219
https://doi.org/10.1351/pac199769030605
https://doi.org/10.1351/pac199769030605