An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE)

Autor: Erin E. Gaughan, Tom M. Quinn, Andrew Mills, Annya M. Bruce, Jean Antonelli, Alison C. MacKinnon, Vassilios Aslanis, Feng Li, Richard O’Connor, Cecilia Boz, Ross Mills, Philip Emanuel, Matthew Burgess, Giulia Rinaldi, Asta Valanciute, Bethany Mills, Emma Scholefield, Gareth Hardisty, Emily Gwyer Findlay, Richard A. Parker, John Norrie, James W. Dear, Ahsan R. Akram, Oliver Koch, Kate Templeton, David H. Dockrell, Timothy S. Walsh, Stephen Partridge, Duncan Humphries, Jie Wang-Jairaj, Robert J. Slack, Hans Schambye, De Phung, Lise Gravelle, Bertil Lindmark, Manu Shankar-Hari, Nikhil Hirani, Tariq Sethi, Kevin Dhaliwal

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 207:138-149

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43fb8472c9f7aba3f7abdc6b479f8ec2
https://doi.org/10.1164/rccm.202203-0477oc

Supplementary Material from An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade

Autor: Alison C. MacKinnon, Tariq Sethi, Hans Schambye, Susan Tantawi, Lise Gravelle, Anders Pedersen, Paul Ford, Hakon Leffler, Ulf J. Nilsson, Fredrik R. Zetterberg, Neil C. Henderson, Stuart J. Forbes, Christopher D. Gregory, Sarah E.M. Howie, Brian J. McHugh, Claire M. Rooney, Eleni Kouverianou, Lynda Vuong

Supplementary methods and figure legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7b4586316a80af95730b66e434daab
https://doi.org/10.1158/0008-5472.22424039.v1

Data from An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade

Autor: Alison C. MacKinnon, Tariq Sethi, Hans Schambye, Susan Tantawi, Lise Gravelle, Anders Pedersen, Paul Ford, Hakon Leffler, Ulf J. Nilsson, Fredrik R. Zetterberg, Neil C. Henderson, Stuart J. Forbes, Christopher D. Gregory, Sarah E.M. Howie, Brian J. McHugh, Claire M. Rooney, Eleni Kouverianou, Lynda Vuong

A combination therapy approach is required to improve tumor immune infiltration and patient response to immune checkpoint inhibitors that target negative regulatory receptors. Galectin-3 is a β-galactoside-binding lectin that is highly expressed wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::577ccef9b69fac6f4c7c1b40ed516379
https://doi.org/10.1158/0008-5472.c.6511667.v1

An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE):A Phase Ib/IIa Randomised Controlled Trial

Autor: Erin E, Gaughan, Tom M, Quinn, Andrew, Mills, Annya M, Bruce, Jean, Antonelli, Alison, MacKinnon, Vassilios, Aslanis, Feng, Li, Richard, O'Connor, Cecilia, Boz, Ross, Mills, Philip, Emanuel, Matthew, Burgess, Giulia, Rinaldi, Asta, Valanciute, Bethany, Mills, Emma, Scholefield, Gareth, Hardisty, Emily, Gwyer Findlay, Richard A, Parker, John, Norrie, James W, Dear, Ahsan R, Akram, Oliver, Koch, Kate, Templeton, David H, Dockrell, Timothy S, Walsh, Stephen, Partridge, Duncan, Humphries, Jie, Wang-Jairaj, Robert J, Slack, Hans, Schambye, De, Phung, Lise, Gravelle, Bertil, Lindmark, Manu, Shankar-Hari, Nikhil, Hirani, Tariq, Sethi, Kevin, Dhaliwal

Publikováno v: Gaughan, E E, Quinn, T M, Mills, A, Bruce, A M, Antonelli, J, Mackinnon, A, Aslanis, V, Li, F, O'connor, R, Boz, C, Mills, R, Emanuel, P, Burgess, M, Rinaldi, G, Valanciute, A, Mills, B, Scholefield, E, Hardisty, G, Gwyer Findlay, E, Parker, R A, Norrie, J, Dear, J W, Akram, A R, Koch, O, Templeton, K, Dockrell, D H, Walsh, T S, Partridge, S, Humphries, D, Wang-jairaj, J, Slack, R J, Schambye, H, Phung, D, Gravelle, L, Lindmark, B, Shankar-Hari, M, Hirani, N, Sethi, T & Dhaliwal, K 2022, ' An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE) : A Phase Ib/IIa Randomised Controlled Trial ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.202203-0477OC

Rationale: High circulating galectin-3 is associated with poor outcomes in patients with COVID-19. We hypothesised that GB0139, a potent inhaled thiodigalactoside galectin-3 inhibitor with anti-inflammatory and antifibrotic actions, would be safely a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4cbdceb9f003b857818278fa3a4d79ec
https://www.pure.ed.ac.uk/ws/files/298426001/rccm.202203_0477oc_1_.pdf

The Effect of pH on β2 Adrenoceptor Function

Autor: Roland Seifert, Søren G. F. Rasmussen, Brian K. Kobilka, Pejman Ghanouni, Tae Weon Lee, Hans Schambye, Ulrik Gether

Publikováno v: Journal of Biological Chemistry. 275:3121-3127

The transition of rhodopsin from the inactive to the active state is associated with proton uptake at Glu134 (1), and recent mutagenesis studies suggest that protonation of the homologous amino acid in the α1Badrenergic receptor (Asp142) may be invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b03c0a9a398d067dad13bf9d46d89de
https://doi.org/10.1074/jbc.275.5.3121