Zobrazeno 1 - 10
of 444
pro vyhledávání: '"Hans R. Schöler"'
Autor:
Thorsten Schaefer, Nitish Mittal, Hui Wang, Meric Ataman, Silvia Candido, Jonas Lötscher, Sergiy Velychko, Lionel Tintignac, Thomas Bock, Anastasiya Börsch, Jochen Baßler, Tata Nageswara Rao, Jakub Zmajkovic, Sarah Roffeis, Jordan Löliger, Francis Jacob, Alain Dumlin, Christoph Schürch, Alexander Schmidt, Radek C. Skoda, Matthias P. Wymann, Christoph Hess, Hans R. Schöler, Holm Zaehres, Ed Hurt, Mihaela Zavolan, Claudia Lengerke
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114807- (2024)
Summary: Stemness and pluripotency are mediated by transcriptional master regulators that promote self-renewal and repress cell differentiation, among which is the high-mobility group (HMG) box transcription factor SOX2. Dysregulated SOX2 expression,
Externí odkaz:
https://doaj.org/article/3f4435c1df914aa5bdc0b2931130faf7
Autor:
Isabel Rosety, Alise Zagare, Claudia Saraiva, Sarah Nickels, Paul Antony, Catarina Almeida, Enrico Glaab, Rashi Halder, Sergiy Velychko, Thomas Rauen, Hans R. Schöler, Silvia Bolognin, Thomas Sauter, Javier Jarazo, Rejko Krüger, Jens C. Schwamborn
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract The mechanisms underlying Parkinson’s disease (PD) etiology are only partially understood despite intensive research conducted in the field. Recent evidence suggests that early neurodevelopmental defects might play a role in cellular susce
Externí odkaz:
https://doaj.org/article/c8a751fed40447b48458240c44c2fae3
Autor:
Farsam Eliat, Rebecca Sohn, Henrik Renner, Theresa Kagermeier, Stefan Volkery, Heike Brinkmann, Nils Kirschnick, Friedemann Kiefer, Martha Grabos, Katharina Becker, Ivan Bedzhov, Hans R. Schöler, Jan M. Bruder
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract In recent years, 3D cell culture has been gaining a more widespread following across many fields of biology. Tissue clearing enables optical analysis of intact 3D samples and investigation of molecular and structural mechanisms by homogenizi
Externí odkaz:
https://doaj.org/article/73f74211564f4e0996b0fbd8dae25874
Autor:
Lisanne Korn, Anna M. Speicher, Christina B. Schroeter, Lukas Gola, Thilo Kaehne, Alexander Engler, Paul Disse, Juncal Fernández-Orth, Júlia Csatári, Michael Naumann, Guiscard Seebohm, Sven G. Meuth, Hans R. Schöler, Heinz Wiendl, Stjepana Kovac, Matthias Pawlowski
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102597- (2023)
Tauopathies are a major type of proteinopathies underlying neurodegenerative diseases. Mutations in the tau-encoding MAPT-gene lead to hereditary cases of frontotemporal lobar degeneration (FTLD)-tau, which span a wide phenotypic and pathological spe
Externí odkaz:
https://doaj.org/article/5a3136405087409ab46b3e0e9f1c2568
Autor:
Markus C. Doeser, Julia Krygin, Albrecht Röpke, Dong Han, Roland Wedlich-Söldner, Hans R. Schöler, Hermann Pavenstädt, Kee-Pyo Kim
Publikováno v:
Stem Cell Research, Vol 62, Iss , Pp 102826- (2022)
An induced pluripotent stem cell (hiPSC) line (MPIi008-A) was generated from fibroblasts of a 1-year-old male patient with Denys-Drash syndrome using lentiviral delivery of reprogramming factors OCT4, SOX2, KLF4 and c-MYC. The MPIi008-A iPSC line exh
Externí odkaz:
https://doaj.org/article/d2bab3d16bad401b90b206bcc9b0d4ef
Autor:
Rui Fan, Yung Su Kim, Jie Wu, Rui Chen, Dagmar Zeuschner, Karina Mildner, Kenjiro Adachi, Guangming Wu, Styliani Galatidou, Jianhua Li, Hans R. Schöler, Sebastian A. Leidel, Ivan Bedzhov
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Embryonic diapause is a state of dormancy with poorly understood mechanisms of embryo intrinsic regulation. Here, the authors show that murine diapause is a dynamic process, where tissue-scale reorganization of the pluripotent lineage is controlled i
Externí odkaz:
https://doaj.org/article/8ca51a4f837f4e888adc4dfe1fda8fa3
Autor:
Gemma Gomez-Giro, Jonathan Arias-Fuenzalida, Javier Jarazo, Dagmar Zeuschner, Muhammad Ali, Nina Possemis, Silvia Bolognin, Rashi Halder, Christian Jäger, Willemijn F. E. Kuper, Peter M. van Hasselt, Holm Zaehres, Antonio del Sol, Herman van der Putten, Hans R. Schöler, Jens C. Schwamborn
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract The juvenile form of neuronal ceroid Lipofuscinosis (JNCL) is the most common form within this group of rare lysosomal storage disorders, causing pediatric neurodegeneration. The genetic disorder, which is caused by recessive mutations affec
Externí odkaz:
https://doaj.org/article/e28ca03024ec42bf892e968c69946796
Autor:
Henrik Renner, Katharina J. Becker, Theresa E. Kagermeier, Martha Grabos, Farsam Eliat, Patrick Günther, Hans R. Schöler, Jan M. Bruder
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Toxicity testing is a crucial step in the development and approval of chemical compounds for human contact and consumption. However, existing model systems often fall short in their prediction of human toxicity in vivo because they may not sufficient
Externí odkaz:
https://doaj.org/article/3fafc522595e473c9de7213b4e759c51
Autor:
Vikas Malik, Laura V. Glaser, Dennis Zimmer, Sergiy Velychko, Mingxi Weng, Markus Holzner, Marius Arend, Yanpu Chen, Yogesh Srivastava, Veeramohan Veerapandian, Zahir Shah, Miguel A. Esteban, Huating Wang, Jiekai Chen, Hans R. Schöler, Andrew P. Hutchins, Sebastiaan H. Meijsing, Sebastian Pott, Ralf Jauch
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Oct4, along with Sox2 and Klf4 can induce pluripotency, but structurally similar factors like Oct6 cannot. Here, using pluripotency competent and incompetent factors, the authors show that Sox2 plays a dominant role in facilitating chromatin opening
Externí odkaz:
https://doaj.org/article/5d839fd6128d4d118a7cbf72a69b4f17
Autor:
Lydia Reinhardt, Susanne Kordes, Peter Reinhardt, Michael Glatza, Matthias Baumann, Hannes C.A. Drexler, Sascha Menninger, Gunther Zischinsky, Jan Eickhoff, Claudia Fröb, Prabesh Bhattarai, Guruchandar Arulmozhivarman, Lara Marrone, Antje Janosch, Kenjiro Adachi, Martin Stehling, Eric N. Anderson, Masin Abo-Rady, Marc Bickle, Udai Bhan Pandey, Michell M. Reimer, Caghan Kizil, Hans R. Schöler, Peter Nussbaumer, Bert Klebl, Jared L. Sterneckert
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 502-517 (2019)
Summary: Neuroinflammation is a hallmark of neurological disorders and is accompanied by the production of neurotoxic agents such as nitric oxide. We used stem cell-based phenotypic screening and identified small molecules that directly protected neu
Externí odkaz:
https://doaj.org/article/d6324808720f45358bb83abf2c104f0a