Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Hans Peter Märki"'
Autor:
Werner Neidhart, Tanja Schulz-Gasch, Armin Ruf, Matthias Nettekoven, Hans Peter Märki, Bernd Kuhn, Daniel Hunziker, Aurelia Conte, Kurt Amrein, Jean Ackermann, Alexander V. Mayweg
Publikováno v:
CHIMIA, Vol 69, Iss 7-8 (2015)
Medicinal chemistry has been transformed by major technological and conceptual innovations over the last three decades: structural biology and bioinformatics, structure and property based molecular design, the concepts of multidimensional optimizatio
Externí odkaz:
https://doaj.org/article/3b529670cd084da4a0e403988df5e367
Autor:
Raimund Dutzler, Beat Ernst, Matthias A. Hediger, Dietrich Keppler, Peter Mohr, Werner Neidhart, Hans Peter Märki
Publikováno v:
CHIMIA, Vol 64, Iss 9 (2010)
During a half-day symposium, the topic 'Channels and Transporters' was covered with five lectures, including a presentation on 'Introduction and Basics of Channels and Transporters' by Beat Ernst, lectures on structure, function and physiology of cha
Externí odkaz:
https://doaj.org/article/8e38c0172a22400e96efe3c31d35bcca
Publikováno v:
CHIMIA, Vol 63, Iss 9 (2009)
'Frontiers in Medicinal Chemistry 2009' was organized as a joint German-Swiss meeting at the University of Heidelberg. It covered the areas of kinases and nuclear hormone receptors, inflammatory diseases, atherosclerosis and neuropsychiatry. Special
Externí odkaz:
https://doaj.org/article/4b5a01f307974dc9983cc58e95a86db5
Autor:
Ruth Duncan, Iwao Ojima, Dario Neri, Nobuo Shimma, Hisafumi Okabe, Hideo Ishitsuka, Hans Peter Märki
Publikováno v:
CHIMIA, Vol 62, Iss 11 (2008)
Specific targeting of drugs to their respective target organs or tissues is challenging. Substantial research efforts have been undertaken in the recent past to develop target specific drugs or drug conjugates. Such concepts are most relevant in rath
Externí odkaz:
https://doaj.org/article/91a053b54cb141e3959ea5317a12a247
Publikováno v:
CHIMIA, Vol 61, Iss 9 (2007)
The 2007 congress Frontiers in Medicinal Chemistry was organized as a joint German–Swiss meeting on medicinal chemistry and was held at the Freie Universität Berlin. It focused on the areas of antiinfectives and tropical diseases, CNS disorders an
Externí odkaz:
https://doaj.org/article/db9dbdfc140d48649d99f63a799deca4
Autor:
Gerd Folkers, Alumit Ishai, Markus Rudin, Pius August Schubiger, Matthias Bräutigam, Hanns Möhler, Hans Peter Märki
Publikováno v:
CHIMIA, Vol 60, Iss 11 (2006)
Imaging technologies have experienced rapid progress and are currently used widely both in medical diagnostics and in research. Imaging beyond X-ray and standard MRI became established in recent years. The extended set of imaging methodologies availa
Externí odkaz:
https://doaj.org/article/b8815857479f48a6a8ce3a1bd6f51760
Publikováno v:
CHIMIA, Vol 59, Iss 9 (2005)
Externí odkaz:
https://doaj.org/article/87484a99ebab4b38a5fff06dccabd53a
Autor:
Henrietta Dehmlow, Ralf Thoma, Armin Ruf, Narendra Panday, Elisabeth Von Der Mark, Olivier Morand, Hans Peter Märki, Manfred Kansy, Peter Hartman, Philippe Coassolo, Alexander Chucholowski, Denise Blum-Kaelin, Johannes Aebi, Jean Ackermann, Tanja Schulz-Gasch
Publikováno v:
CHIMIA, Vol 59, Iss 3 (2005)
Novel inhibitors of oxidosqualene cyclase (OSC) for the treatment of dyslipidemia are reported. Starting point for the chemistry program was a set of compounds derived from a fungicide project which, in addition to high affinity for OSC from Candida
Externí odkaz:
https://doaj.org/article/52a208c1b0c345b49b3846af115d21f8
Autor:
Remo Hochstrasser, Mingwei Zhou, Giorgio Ottaviani, Wenming Chen, Stephan Müller, Alexander V. Mayweg, Benoit Hornsperger, Johannes Aebi, Lisha Wang, Philippe Verry, Dongbo Li, William Riboulet, Hans-Peter Märki, Jian Xin, Andreas Kuglstatter, Yongfu Liu, Zhanguo Wang, Jun Wu, Bernd Kuhn, Susanne Mohr, Jörg Benz, Stephan Kirchner, Hong C. Shen, Kurt Amrein, Xuefei Tan
Publikováno v:
Journal of medicinal chemistry. 63(13)
Aldosterone synthase (CYP11B2) inhibitors have been explored in recent years as an alternative therapeutic option to mineralocorticoid receptor (MR) antagonists to reduce elevated aldosterone levels, which are associated with deleterious effects on v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cc7bef96ebf533ac22d0c374787411
https://pubmed.ncbi.nlm.nih.gov/32530624
https://pubmed.ncbi.nlm.nih.gov/32530624
Autor:
Hans Peter Märki, Bernd Kuhn, Kurt Amrein, Robert Britton, Johannes Aebi, Marjorie A. Carnero Corrales, Rainer E. Martin, Alexander V. Mayweg, Mario Lenz, Johannes Lehmann, Thibaut Alzieu
Publikováno v:
Organic & Biomolecular Chemistry. 14:5922-5927
A series of cyclopenta[c]pyridine aldosterone synthase (AS) inhibitors were conveniently accessed using batch or continuous flow Kondrat'eva reactions. Preparation of the analogous cyclohexa[c]pyridines led to the identification of a potent and more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3022a6d08b79c0f5152e065da24d642b
https://doi.org/10.1039/c6ob00848h
https://doi.org/10.1039/c6ob00848h