Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hans P. Gertje"'
Autor:
Yongzhen Liu, Thomas R. Cafiero, Debby Park, Abhishek Biswas, Benjamin Y. Winer, Cheul H. Cho, Yaron Bram, Vasuretha Chandar, Aoife K. O’ Connell, Hans P. Gertje, Nicholas Crossland, Robert E. Schwartz, Alexander Ploss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Hepatitis B virus (HBV) only infects humans and chimpanzees, posing major challenges for modeling HBV infection and chronic viral hepatitis. The major barrier in establishing HBV infection in non-human primates lies at incompatibilities betw
Externí odkaz:
https://doaj.org/article/715209dd3f1c45be80f29128c56a1eea
Autor:
Yongzhen Liu, Stephanie Maya, Sebastian Carver, Aoife K. O’Connell, Anna E. Tseng, Hans P. Gertje, Kathleen Seneca, Ronald G. Nahass, Nicholas A. Crossland, Alexander Ploss
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTHepatitis B virus (HBV) infection remains a major public health problem and, in associated co-infection with hepatitis delta virus (HDV), causes the most severe viral hepatitis and accelerated liver disease progression. As a defective satelli
Externí odkaz:
https://doaj.org/article/b3f1e5ed3cf34095926b0a10f4fa94cc
Autor:
Yongzhen Liu, Debby Park, Thomas R. Cafiero, Yaron Bram, Vasuretha Chandar, Anna Tseng, Hans P. Gertje, Nicholas A. Crossland, Lishan Su, Robert E. Schwartz, Alexander Ploss
Publikováno v:
JHEP Reports, Vol 4, Iss 9, Pp 100535- (2022)
Background & Aims: HBV exhibits wide genetic diversity with at least 9 genotypes (GTs), which differ in terms of prevalence, geographic distribution, natural history, disease progression, and treatment outcome. However, differences in HBV replicative
Externí odkaz:
https://doaj.org/article/1554fc7886654cae9e56bd1c430ac1fc
Autor:
Lei Wei, Thomas R. Cafiero, Anna Tseng, Hans P. Gertje, Andrew Berneshawi, Nicholas A. Crossland, Alexander Ploss
Publikováno v:
JHEP Reports, Vol 4, Iss 9, Pp 100534- (2022)
Background & Aims: HBV has a narrow host restriction, with humans and chimpanzees representing the only known natural hosts. The molecular correlates of resistance in species that are commonly used in biomedical research, such as mice, are currently
Externí odkaz:
https://doaj.org/article/b24879bf35b2455c990b168a48224d44
Autor:
Raymond Rosenbloom, Igor Gavrish, Anna E. Tseng, Kerstin Seidel, Shivraj M. Yabaji, Hans P. Gertje, Bertrand R. Huber, Igor Kramnik, Nicholas A. Crossland
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 5999 (2022)
Pulmonary infections caused by the group of nontuberculosis mycobacteria (NTM), Mycobacterium avium complex (MAC), are a growing public health concern with incidence and mortality steadily increasing globally. Granulomatous inflammation is the hallma
Externí odkaz:
https://doaj.org/article/73d4044ecf9f4e72bc13f0c9c4db0f1f
Autor:
Mariano Carossino, Devin Kenney, Aoife K. O’Connell, Paige Montanaro, Anna E. Tseng, Hans P. Gertje, Kyle A. Grosz, Maria Ericsson, Bertrand R. Huber, Susanna A. Kurnick, Saravanan Subramaniam, Thomas A. Kirkland, Joel R. Walker, Kevin P. Francis, Alexander D. Klose, Neal Paragas, Markus Bosmann, Mohsan Saeed, Udeni B. R. Balasuriya, Florian Douam, Nicholas A. Crossland
Publikováno v:
Viruses, Vol 14, Iss 3, p 535 (2022)
Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) represe
Externí odkaz:
https://doaj.org/article/f6b43f0802ad4855911f2d783877a9ee
Autor:
Da-Yuan Chen, Chue Vin Chin, Devin Kenney, Alexander H. Tavares, Nazimuddin Khan, Hasahn L. Conway, GuanQun Liu, Manish C. Choudhary, Hans P. Gertje, Aoife K. O’Connell, Scott Adams, Darrell N. Kotton, Alexandra Herrmann, Armin Ensser, John H. Connor, Markus Bosmann, Jonathan Z. Li, Michaela U. Gack, Susan C. Baker, Robert N. Kirchdoerfer, Yachana Kataria, Nicholas A. Crossland, Florian Douam, Mohsan Saeed
Publikováno v:
Nature. 615:143-150
Autor:
Da-Yuan Chen, Devin Kenney, Chue Vin Chin, Alexander H. Tavares, Nazimuddin Khan, Hasahn L. Conway, GuanQun Liu, Manish C. Choudhary, Hans P. Gertje, Aoife K. O’Connell, Darrell N. Kotton, Alexandra Herrmann, Armin Ensser, John H. Connor, Markus Bosmann, Jonathan Z. Li, Michaela U. Gack, Susan C. Baker, Robert N. Kirchdoerfer, Yachana Kataria, Nicholas A. Crossland, Florian Douam, Mohsan Saeed
Publikováno v:
bioRxiv
The recently identified, globally predominant SARS-CoV-2 Omicron variant (BA.1) is highly transmissible, even in fully vaccinated individuals, and causes attenuated disease compared with other major viral variants recognized to date1–7. The Omicron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3279a4a97381ecc3f70f982468c869cc
https://europepmc.org/articles/PMC9580375/
https://europepmc.org/articles/PMC9580375/
Autor:
Anna E. Tseng, Mariano Carossino, Hans P. Gertje, Aoife K. O’Connell, Suryaram Gummuluru, Vijaya B Kolachalama, Udeni B. R. Balasuriya, John H. Connor, Richard S. Bennett, David X. Liu, Lisa E. Hensley, Nicholas A. Crossland
Publikováno v:
Veterinary Pathology. :030098582311719
The liver is an early systemic target of Ebola virus (EBOV), but characterization beyond routine histopathology and viral antigen distribution is limited. We hypothesized Ebola virus disease (EVD) systemic proinflammatory responses would be reflected
Autor:
Devin J. Kenney, Aoife K. O’Connell, Jacquelyn Turcinovic, Paige Montanaro, Ryan M. Hekman, Tomokazu Tamura, Andrew R. Berneshawi, Thomas R. Cafiero, Salam Al Abdullatif, Benjamin Blum, Stanley I. Goldstein, Brigitte L. Heller, Hans P. Gertje, Esther Bullitt, Alexander J. Trachtenberg, Elizabeth Chavez, Evans Tuekam Nono, Catherine Morrison, Anna E. Tseng, Amira Sheikh, Susanna Kurnick, Kyle Grosz, Markus Bosmann, Maria Ericsson, Bertrand R. Huber, Mohsan Saeed, Alejandro B. Balazs, Kevin P. Francis, Alexander Klose, Neal Paragas, Joshua D. Campbell, John H. Connor, Andrew Emili, Nicholas A. Crossland, Alexander Ploss, Florian Douam
Publikováno v:
Cell Reports. 39:110714
The human immunological mechanisms defining the clinical outcome of SARS-CoV-2 infection remain elusive. This knowledge gap is mostly driven by the lack of appropriate experimental platforms recapitulating human immune responses in a controlled human