Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Hans Minderman"'
Autor:
Lauren Williams, Paul K Wallace, Pawel Kalinski, Mateusz Opyrchal, Kathleen M Kokolus, Shipra Gandhi, Kristopher Attwood, Agnieszka Witkiewicz, Hans Minderman, Kah Teong Soh, Melissa J Grimm, Ronald T Slomba, Adrienne Groman, Mary Lynne Tarquini, Orla Maguire, Tracey L O’Connor, Amy P Early, Ellis G Levine
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background Presence of cytotoxic T lymphocytes (CTL) in the tumor microenvironment (TME) predicts the effectiveness of cancer immunotherapies. The ability of toll-like receptor 3 (TLR3) ligands, interferons (IFNs) and COX2 inhibitors to synergistical
Externí odkaz:
https://doaj.org/article/2d1ecf8be6c34222ae25dc9f47cf3dc6
Autor:
Kathleen M. Tornatore, Kris Attwood, Daniel Brazeau, Jason Sprowl, Shirley Chang, Aijaz Gundroo, Hans Minderman, Rocco C. Venuto
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 2, Pp 184-192 (2023)
Abstract Kidney allograft survival remains poorer in Black compared to White recipients due to racial differences in calcineurin inhibitor (CNI) pharmacology. P‐glycoprotein (P‐gp), an ABC efflux transporter expressed in peripheral blood mononucl
Externí odkaz:
https://doaj.org/article/c87ef4fda0da497e9af057c4ca00fe13
Autor:
Anna Mistarz, Matthew Graczyk, Marta Winkler, Prashant K. Singh, Eduardo Cortes, Anthony Miliotto, Song Liu, Mark Long, Li Yan, Aimee Stablewski, Kieran O’Loughlin, Hans Minderman, Kunle Odunsi, Hanna Rokita, A.J. Robert McGray, Emese Zsiros, Danuta Kozbor
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 38-50 (2021)
We have demonstrated that oncolytic vaccinia virus synergizes with doxorubicin (DOX) in inducing immunogenic cell death in platinum-resistant ovarian cancer cells and increases survival in syngeneic and xenograft tumor models. However, the mechanisms
Externí odkaz:
https://doaj.org/article/9ac365f46fa94257acf87de89c821ff0
Autor:
Takaaki Oba, Mark D. Long, Tibor Keler, Henry C. Marsh, Hans Minderman, Scott I. Abrams, Song Liu, Fumito Ito
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Strategies to increase T cell infiltration within the tumor microenvironment could improve response to immune checkpoint blockade. Here the authors show that a combinatorial regimen based on Flt3L, radiotherapy, and TLR3/CD40 stimulation promotes int
Externí odkaz:
https://doaj.org/article/624c24703da040c89811cce847e51d8c
Autor:
Hans Minderman, Maulasri Bhatta, Gautam N Shenoy, Jenni L Loyall, Brian D Gray, Meghana Bapardekar, Alexis Conway, Raymond J Kelleher Jr, Beatriz M Carreno, Gerald Linette, Leonard D Shultz, Sathy V Balu-Iyer, Koon Yan Pak, Richard B Bankert
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Externí odkaz:
https://doaj.org/article/459c116054b34eebac5200ea18da9508
Autor:
Kunle Odunsi, Takaaki Oba, Hans Minderman, Kenichi Makino, Ryutaro Kajihara, Toshihiro Yokoi, Ryoko Araki, Masumi Abe, Alfred E Chang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Background Dendritic cells (DCs) are a promising therapeutic target in cancer immunotherapy given their ability to prime antigen-specific T cells, and initiate antitumor immune response. A major obstacle for DC-based immunotherapy is the difficulty t
Externí odkaz:
https://doaj.org/article/b0b53910545d499abfe3d46f4a5b5925
Autor:
Tibor Keler, Song Liu, Mark Long, Henry Marsh, Takaaki Oba, Fumito Ito, Hans Minderman, Scott Abrams
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/52885d99fede430bbef66095a939ec77
Autor:
Shin La Shu, Yunchen Yang, Cheryl L. Allen, Edward Hurley, Kaity H. Tung, Hans Minderman, Yun Wu, Marc S. Ernstoff
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Both exosomes and soluble factors have been implicated in the generation of an immunosuppressive tumour microenvironment. Determining the contribution of each requires stringent control of purity of the isolated analytes. The present study compares s
Externí odkaz:
https://doaj.org/article/65c3fbcb93124832966e61cd426e825d
Autor:
Amy W Ku, Jason B Muhitch, Colin A Powers, Michael Diehl, Minhyung Kim, Daniel T Fisher, Anand P Sharda, Virginia K Clements, Kieran O'Loughlin, Hans Minderman, Michelle N Messmer, Jing Ma, Joseph J Skitzki, Douglas A Steeber, Bruce Walcheck, Suzanne Ostrand-Rosenberg, Scott I Abrams, Sharon S Evans
Publikováno v:
eLife, Vol 5 (2016)
Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive network that drives cancer escape by disabling T cell adaptive immunity. The prevailing view is that MDSC-mediated immunosuppression is restricted to tissues where MDSC co-min
Externí odkaz:
https://doaj.org/article/3703c01018fe4546bf5280e8e6082a72
Autor:
Renuka V. Iyer, Orla Maguire, Minhyung Kim, Leslie I. Curtin, Sandra Sexton, Daniel T. Fisher, Sarah A. Schihl, Gerald Fetterly, Stephan Menne, Hans Minderman
Publikováno v:
Cancers, Vol 11, Iss 5, p 681 (2019)
The multikinase inhibitor sorafenib is the only standard first-line therapy for hepatocellular carcinoma (HCC). Here, we report the dose-dependent effects of sorafenib on the immune response, which is related to nuclear factor of activated T cells 1
Externí odkaz:
https://doaj.org/article/3b53346c18c64b85a87ed94b0b8cbc55