Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Hans Lengsfeld"'
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 62:19-26
The inhibitory effects of tetrahydrolipstatin (THL) on the hydrolytic activity of human pancreatic lipase (HPL) and T. lanuginosa lipase (TLL) on various lipidic substrates ‘poisoned’ with THL as previously described was studied, using either the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3df0600765d648cca8ccac2ec5bb1a6
https://doi.org/10.1016/j.molcatb.2009.08.011
https://doi.org/10.1016/j.molcatb.2009.08.011
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 58:41-47
Tetrahydrolipstatin (THL, Orlistat) is a potent inhibitor of gastrointestinal lipases. Using the pH-stat technique we report that, in the absence of substrate, THL (at a molar excess of 100) inhibits rapidly (after few minutes of incubation) human pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6161009c785a1aa3990eccd455319f81
https://doi.org/10.1016/j.molcatb.2008.11.003
https://doi.org/10.1016/j.molcatb.2008.11.003
Autor:
Sonja Nisslé, Paul Hadvary, Helmut R. Maecke, Christoph Beglinger, Daniel Matzinger, Juergen Drewe, Lukas Degen, Hans Lengsfeld
Publikováno v:
Digestion. 74:131-139
The limited effectiveness of orlistat, an inhibitor of gastrointestinal lipases, in inhibiting fat digestion is not completely understood. Therefore we studied the effect of orally and duodenally administered orlistat on gastric emptying, cholecystok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0266096f1334087fa6bceff91cdc43c
https://doi.org/10.1159/000098560
https://doi.org/10.1159/000098560
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1682:72-79
Two types of experiments were performed to study the reversibility of interfacial adsorption of pancreatic lipase (PL) to fat droplets during lipolysis. Lipolysis was measured in olive oil/gum arabic emulsions containing radiolabeled triolein in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fa98ca0de9f67c69d4346917a54a7a
https://doi.org/10.1016/j.bbalip.2003.12.011
https://doi.org/10.1016/j.bbalip.2003.12.011
Autor:
Patrick Kunz, Andreas Steingoetter, Werner Schwizer, Karsten Mäder, Peter Boesiger, Miriam Thumshirn, Hans Lengsfeld, Michael Fried, Dominik Weishaupt
Publikováno v:
Pharmaceutical Research, 20 (12)
To develop a magnetic resonance imaging (MRI) technique for assessing in vivo properties of orally ingested gastric-retentive tablets under physiologic conditions.Tablets with different floating characteristics (tablet A-C) were marked with superpara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b6556df7ee1a62863cf9084c45ff01
https://doi.org/10.1023/b:pham.0000008049.40370.5a
https://doi.org/10.1023/b:pham.0000008049.40370.5a
Autor:
Peter Boesiger, P. Kunz, Hans Lengsfeld, Karsten Mäder, Dominik Weishaupt, Andreas Steingoetter, Werner Schwizer, Miriam Thumshirn, Michael Fried
Publikováno v:
Alimentary Pharmacology & Therapeutics. 18:713-720
Summary Background : Modern medical imaging modalities can trace labelled oral drug dosage forms in the gastrointestinal tract, and thus represent important tools for the evaluation of their in vivo performance. The application of gastric-retentive d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::964eb735562272b2d92bc4d4642bb4ec
https://doi.org/10.1046/j.1365-2036.2003.01655.x
https://doi.org/10.1046/j.1365-2036.2003.01655.x
Publikováno v:
Chemistry and Physics of Lipids. 119:41-49
The transfer of radiolabelled orlistat ([14C]orlistat), a potent gastrointestinal lipase inhibitor, through an oil-water interface from a single oil droplet to an aqueous phase was investigated, using an oil drop tensiometer. The absolute transfer fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdd380a179044557acc77f2694554d3
https://doi.org/10.1016/s0009-3084(02)00051-8
https://doi.org/10.1016/s0009-3084(02)00051-8
Autor:
H. Faas, Andreas Steingoetter, Michael Fried, Thomas Rades, Peter Boesiger, Christine Feinle, Hans Lengsfeld, Werner Schwizer
Publikováno v:
Alimentary Pharmacology & Therapeutics. 16:217-224
Background: Controlled delivery of drugs to the small intestine in relation to emptying of an ingested meal is important in various pathophysiological conditions. We investigated the effects of different food consistencies and the amount of co-ingest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18bdee978a1a6e97ea19e1ad4670a7db
https://doi.org/10.1046/j.1365-2036.2002.01154.x
https://doi.org/10.1046/j.1365-2036.2002.01154.x
Autor:
René Laugier, Andre Fleury, Frédéric Carrière, Christoph Beglinger, Francine Ferrato, Stéphane Ransac, Paul Hadvary, Hans Lengsfeld, Josiane De Caro, Christophe Renou, Patricia Sanwald-Ducray, Véronique Lopez, Robert Verger, Alain De Caro
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
The inhibition of digestive lipases by the antiobesity drug Orlistat along with lipolysis levels and fecal fat excretion were measured in healthy humans. Orlistat was found to be a powerful gastric lipase inhibitor, achieving 46.6–91.4% enzyme inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3103f03500a5f6d3f97517fd122a4a0
https://doi.org/10.1152/ajpgi.2001.281.1.g16
https://doi.org/10.1152/ajpgi.2001.281.1.g16
Publikováno v:
Chemistry and Physics of Lipids. 111:73-85
The surface behaviour of two bile salts, sodium deoxycholate (NaDC) and sodium taurodeoxycholate (NaTDC), as well as that of tetrahydrolipstatin (THL), a potent gastrointestinal lipase inhibitor, was studied at air/water and oil/water interfaces, usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65332df43d7cd7877f7a31f2a335eb10
https://doi.org/10.1016/s0009-3084(01)00149-9
https://doi.org/10.1016/s0009-3084(01)00149-9