Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Hans Klose"'
Autor:
Dirk Skowasch, Hans Klose, Ralf Ewert, Heinrike Wilkens, Manuel Richter, Stephan Rosenkranz, Gesine Setzer, Ekkehard Grünig, Michael Halank
Publikováno v:
ERJ Open Research, Vol 10, Iss 1 (2024)
Idiopathic pulmonary arterial hypertension (IPAH) is often diagnosed in elderly patients with many comorbidities. Whereas a clear treatment strategy and risk assessment is recommended for patients with rare classical IPAH, monotherapy with phosphodie
Externí odkaz:
https://doaj.org/article/da8326a6cdfd47e39143aebc9fa318c7
Autor:
Jonna Ostermann, Julian Pott, Jan K. Hennigs, Kevin Roedl, Christoph Sinning, Lars Harbaum, Hans Klose
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
Background The 2022 ESC/ERS guidelines on pulmonary hypertension recommend noninvasive risk assessments based on three clinical variables during follow-up in patients with pulmonary arterial hypertension (PAH). We set out to test whether residual ris
Externí odkaz:
https://doaj.org/article/50e2da88b6f8497986e7e39fe9dbabbd
Autor:
Anna M. Dittrich, Julia Mienert, Julian Pott, Lena Engels, Christoph Sinning, Jan K. Hennigs, Hans Klose, Lars Harbaum
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Background Converging evidence from proteogenomic analyses prioritises thrombospondin-2 (TSP2) as a potential biomarker for idiopathic or heritable pulmonary arterial hypertension (PAH). We aimed to assess TSP2 levels in different forms of pulmonary
Externí odkaz:
https://doaj.org/article/eaae2cbdb2c64fc5bee1c95a307675ac
Autor:
Christina A. Eichstaedt, Zoe Saßmannshausen, Memoona Shaukat, Ding Cao, Panagiota Xanthouli, Henning Gall, Natascha Sommer, Hossein-Ardeschir Ghofrani, Hans-Jürgen Seyfarth, Marianne Lerche, Michael Halank, Janina Kleymann, Nicola Benjamin, Satenik Harutyunova, Benjamin Egenlauf, Katrin Milger, Stephan Rosenkranz, Ralf Ewert, Hans Klose, Marius M. Hoeper, Karen M. Olsson, Mareike Lankeit, Tobias J. Lange, Katrin Hinderhofer, Ekkehard Grünig
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background A genetic predisposition can lead to the rare disease pulmonary arterial hypertension (PAH). Most mutations have been identified in the gene BMPR2 in heritable PAH. However, as of today 15 further PAH genes have been described. Th
Externí odkaz:
https://doaj.org/article/1de528004b62464999a9e805a210de5e
Autor:
Jakob Körbelin, Julius Klein, Christiane Matuszcak, Johannes Runge, Lars Harbaum, Hans Klose, Jan K. Hennigs
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2023)
Pulmonary arterial hypertension (PAH) is a disease characterized by elevated pulmonary vascular resistance and pulmonary artery pressure. Mortality remains high in severe cases despite significant advances in management and pharmacotherapy. Since cur
Externí odkaz:
https://doaj.org/article/de53d35223ee4cb791064e2f55733986
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-8 (2021)
Abstract Background Observational studies on the general population have suggested that airflow obstruction associates with left ventricular (LV) filling. To limit the influence of environmental risk factors/exposures, we used a Mendelian randomisati
Externí odkaz:
https://doaj.org/article/056012d2bc7b48dda18f1394f6aaae26
Autor:
Hans Klose, Kelly M. Chin, Ralf Ewert, Henning Gall, Joseph Parambil, David Poch, Hans-Jürgen Seyfarth, Lene N. Axelsen, Shu-Fang Hsu Schmitz, Claudia Stein, Ioana R. Preston
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background The oral IP receptor agonist selexipag is approved for the long-term treatment of pulmonary arterial hypertension (PAH). Treatment interruptions should be avoided due to the progressive nature of the disease. An intravenous (IV) f
Externí odkaz:
https://doaj.org/article/7eed90b8ee274754ba627fcdb24db711
Autor:
Jan K. Hennigs, Sarah Minner, Pierre Tennstedt, Rolf Löser, Hartwig Huland, Hans Klose, Markus Graefen, Thorsten Schlomm, Guido Sauter, Carsten Bokemeyer, Friedemann Honecker
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract The role of subcellular survivin compartmentalization in the biology and prognosis of prostate cancer is unclear. We therefore investigated subcellular localization of survivin in more than 3000 prostate cancer patients by quantitative immun
Externí odkaz:
https://doaj.org/article/4073062c3dbe48848f9dcf0fce1a9111
Autor:
Barbara Stollfuss, Manuel Richter, Daniel Drömann, Hans Klose, Martin Schwaiblmair, Ekkehard Gruenig, Ralf Ewert, Martin C Kirchner, Frank Kleinjung, Valeska Irrgang, Christian Mueller
Publikováno v:
Journal of Medical Internet Research, Vol 23, Iss 10, p e25163 (2021)
BackgroundPulmonary arterial hypertension restricts the ability of patients to perform routine physical activities. As part of pulmonary arterial hypertension treatment, inhaled iloprost can be administered via a nebulizer that tracks inhalation beha
Externí odkaz:
https://doaj.org/article/e4736d1e589b4b1294dc44b69ddc1a3f
Autor:
Alberto M. Marra, Michael Halank, Nicola Benjamin, Eduardo Bossone, Antonio Cittadini, Christina A. Eichstaedt, Benjamin Egenlauf, Satenik Harutyunova, Christine Fischer, Henning Gall, Hossein Ardeschir Ghofrani, Marius M. Hoeper, Tobias J. Lange, Karen M. Olsson, Hans Klose, Ekkehard Grünig
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Riociguat is a soluble guanylate cyclase stimulator approved for pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTPEH). The objective of this study was to evaluate right heart size and fun
Externí odkaz:
https://doaj.org/article/2e014576ffdf4e1ba9f85d7ded820bf9