Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Hans J. Tritschler"'
Autor:
Hans J. Tritschler, Andrew J.M. Boulton, William J. Litchy, Phillip A. Low, Peter J. Dyck, Rustem Samigullin, Dan Ziegler, Ullrich Munzel, Roy Freeman, Aaron I. Vinik, Joachim Maus, Klemens Schütte
Publikováno v:
Diabetes Care. 34:2054-2060
OBJECTIVE To evaluate the efficacy and safety of α-lipoic acid (ALA) over 4 years in mild-to-moderate diabetic distal symmetric sensorimotor polyneuropathy (DSPN). RESEARCH DESIGN AND METHODS In a multicenter randomized double-blind parallel-group t
Autor:
Hans J. Tritschler, Peter J. Dyck, Peter C. O'Brien, Edward J. Bastyr, Klemens Schuette, Jane E. Norell, William J. Litchy, Rustem Samigullin, Dan Ziegler
Publikováno v:
Diabetes Care. 30:2619-2625
OBJECTIVE—Assessing clinimetric performance of diabetic sensorimotor polyneuropathy (DSPN) end points in single and multicenter trials. RESEARCH DESIGN AND METHODS—Assessed were placebo-treated patients with DSPN in the Viatris and Eli Lilly tria
Autor:
Marion A. Hofmann, Stephan Schiekofer, M. Henkels, Amiral J, Peter P. Nawroth, Michael Morcos, S Gehrke, Reinhard Ziegler, P. Wahl, Hans J. Tritschler, Berend Isermann, T Ehret, V. Borcea
Publikováno v:
Diabetes Research and Clinical Practice. 52:175-183
Oxidative stress plays a central role in the pathogenesis and progression of late microangiopathic complications (diabetic nephropathy) in diabetes mellitus. Previous studies suggested that treatment of diabetic patients with the antioxidant alpha-li
Publikováno v:
Free Radical Biology and Medicine. 30:383-388
We have shown previously that the antioxidant alpha-lipoic acid (ALA) can stimulate glucose transport and can enhance the stimulation of this process by insulin in skeletal muscle from insulin-resistant obese Zucker rats. As insulin can also acutely
Autor:
Reinhard Ziegler, Marion A. Hofmann, Heinz Urich, Hans J. Tritschler, V. Borcea, Peter P. Nawroth, Simon P. Wolff, Jaffar Nourooz-Zadeh, P. Wahl, Barry Halliwell, Martina S. Klevesath
Publikováno v:
Free Radical Biology and Medicine. 26:1495-1500
In the present cross-sectional study, the influence of alpha-lipoic acid on markers of oxidative stress, assessed by measurement of plasma lipid hydroperoxides (ROOHs), and on the balance between oxidative stress and antioxidant defence, determined b
Autor:
Stephan Schiekofer, M. Henkels, Michael Kanitz, V. Borcea, Martina Joswig, Michael Morcos, P. Wahl, Eberhard Ritz, Angelika Bierhaus, Amiral J, Reinhard Ziegler, A. K. M. Abdel Khalek, A. Treusch, Berend Isermann, Marion A. Hofmann, Hans J. Tritschler, T. Weiss, Peter P. Nawroth
Publikováno v:
Diabetologia. 42:222-232
Increased oxidative stress and subsequent activation of the transcription factor NF-kappaB has been linked to the development of late diabetic complications. To determine whether oxidative stress dependent NF-kappaB activation is evident in patients
Autor:
Abdel Khalek Mohamed, Angelika Bierhaus, Peter P. Nawroth, Reinhard Ziegler, Stephan Schiekofer, Hans J. Tritschler
Publikováno v:
BioFactors. 10:157-167
A common endpoint of hyperglycemia dependent cellular changes is the generation of reactive oxygen intermediates (ROIs) and the presence of elevated oxidative stress. Therefore, oxidative stress is supposed to play an important role in the developmen
Autor:
W. Möller, K. Rett, M. Lobisch, M. Reljanovic, H. Mehnert, G. Reichel, K. Schuette, Hans J. Tritschler
Publikováno v:
Free Radical Research. 31:171-179
Short-term trials with the antioxidant thioctic acid (TA) appear to improve neuropathic symptoms in diabetic patients, but the long-term response remains to be established. Therefore, Type 1 and Ty...
Autor:
Hans J. Tritschler, Reinhard Ziegler, Peter Wahl, Marion A. Hofmann, Stephan Schiekofer, Angelika Bierhaus, Michael Kanitz, Michael Morcos, Martina Joswig, Peter P. Nawroth, Vong Lee, Martina S. Klevesath
Publikováno v:
Diabetes Care. 21:1310-1316
OBJECTIVE The redox-sensitive transcription factor nuclear factor-kB (NF-kB) is believed to contribute to late diabetic complications. It is unknown whether NF-kB is influenced by glycemic control. RESEARCH DESIGN AND METHODS To determine whether NF-
Autor:
Kristian F. Hanssen, Hans-Jacob Bangstad, Hans J. Tritschler, Tore Julsrud Berg, Simon P. Wolff, Jaffar Nourooz-Zadeh
Publikováno v:
Diabetes Care. 21:1295-1300
OBJECTIVE An association between reactive oxygen species and diabetic micro- and macrovascular complications has been proposed. In the present study, we have examined the effect of an improved blood glucose control on plasma levels of hydroperoxides