Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hans J. Prochaska"'
Autor:
Thomas W. Kensler, Hans J. Prochaska, Shuang Yuan Kuang, Baibai Chen, Jia-Sheng Wang, Geng Sun Qian, Mary B. Gorman, John D. Groopman, Xia He, Yuan Rong Zhu, Bao Chu Zhang, Audrey Zarba, Lu Yi Yu, Kathy J. Helzlsouer, Patricia A. Egner, Yan Wu, Xi Fang, Alvaro Muñoz, Yan Feng Li, Cheryl Enger, Lisa P. Jacobson, Gary B. Gordon, Jin Bing Wang, Silvio De Flora, Qi Nan Zhang, Nancy E. Davidson
Publikováno v:
Journal of Cellular Biochemistry. 67:166-173
Oltipraz has been used clinically in many regions of the world as an antischistosomal agent and is an effective inhibitor of aflatoxin hepatocarcinogenesis in rats. This chemopreventive action of oltipraz results primarily from an altered balance in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::712c4f591bc46fda7a7428e31c1058f5
https://doi.org/10.1002/(sici)1097-4644(1997)28/29+<166::aid-jcb20>3.0.co
https://doi.org/10.1002/(sici)1097-4644(1997)28/29+<166::aid-jcb20>3.0.co
Publikováno v:
Archives of Biochemistry and Biophysics. 324:143-152
Oltipraz (5-pyrazinyl-4-methyl-1,2-dithiole-3-thione), which is undergoing clinical evaluation as an anticarcinogen, also inhibits HIV-1 replication (IC50 approximately equal to 10 microM). The inactivation of RT appears to be a relevant antiviral me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28f5f4f2c7fff20d24b43bb46eb587e
https://doi.org/10.1006/abbi.1995.9916
https://doi.org/10.1006/abbi.1995.9916
Publikováno v:
Proceedings of the National Academy of Sciences. 90:3953-3957
Glutathione depletion may play a pivotal role in the pathogenesis of human immunodeficiency virus type-1 (HIV-1) infection. Since certain compounds prevent experimental carcinogenesis by elevating the levels of glutathione and phase II detoxication e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2229852aaf2636f6d9c799b2d596bc
https://doi.org/10.1073/pnas.90.9.3953
https://doi.org/10.1073/pnas.90.9.3953
Publikováno v:
Carcinogenesis. 14:2441-2445
Inducers of Phase II enzymes, already consumed by humans as food additives, medicines or as constituents of vegetables, can prevent experimental carcinogenesis. Since protection is neither carcinogen- nor organ-specific, clinical trials are already u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fadba3b8994e13329bac62d07251283
https://doi.org/10.1093/carcin/14.12.2441
https://doi.org/10.1093/carcin/14.12.2441
Publikováno v:
Biochemistry. 31:824-833
Cibacron Blue, a widely used ligand for affinity chromatography, is a potent inhibitor of NAD(P)H:(quinone-acceptor) oxidoreductase (EC 1.6.99.2) (quinone reductase). This property has been exploited to purify quinone reductase, to identify its nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257121c35f2c4ae997271b4b6f6a91bd
https://doi.org/10.1021/bi00118a027
https://doi.org/10.1021/bi00118a027
Publikováno v:
Carcinogenesis. 12:2393-2396
The induction of quinone reductase [QR; NAD(P)H:(quinone acceptor) oxidoreductase; EC 1.6.99.2] in cultured cells and animal tissues of rodents has provided useful information on mechanisms of protection against carcinogens. We have developed a simpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f7f12ce8f47ef6f7c372d6f86796cf
https://doi.org/10.1093/carcin/12.12.2393
https://doi.org/10.1093/carcin/12.12.2393
Dietary composition is a major determinant of cancer risk in humans and experimental animals. Major and minor components of the diet may enhance or suppress the development of malignancy. Many dietary constituents also modify the metabolism of carcin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81946c95feb1f424b529d5e6c67c0e0c
https://doi.org/10.1533/9781845698256.8.411
https://doi.org/10.1533/9781845698256.8.411
Publikováno v:
Biochemical and biophysical research communications. 221(3)
Metabolite III (MIII, 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-alpha]pyrazine), a major in vivo metabolite of oltipraz (OLT, 5-pyrazinyl-4-methyl-1,2-dithiole-3-thione), appears to disrupt human immunodeficiency virus type 1 (HIV-1) replication at a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a44c97d41090fe85502494047b356a
https://pubmed.ncbi.nlm.nih.gov/8629998
https://pubmed.ncbi.nlm.nih.gov/8629998
Publikováno v:
Journal of cellular biochemistry. Supplement. 22
Glutathione (GSH) levels are markedly depleted in patients infected with human immunodeficiency virus type 1 (HIV-1) and supplementation of media with high concentrations (5-20 mM) of low-molecular weight thiols prevents HIV-1 replication in cultured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b0f628d376d9a5971ff16628b09541
https://pubmed.ncbi.nlm.nih.gov/8538188
https://pubmed.ncbi.nlm.nih.gov/8538188
Autor:
Hans J. Prochaska, Terry D. Lee, Patrick E. Clarke, Paul Talalay, Shiuan Chen, Paulis S. K. Deng, Paul A. Martino, Che‐Hung ‐H Yeh
Publikováno v:
Protein science : a publication of the Protein Society. 3(8)
The amino acid sequence of mouse liver NAD(P)H:quinone acceptor oxidoreductase (EC 1.6.99.2) has been determined by tandem mass spectrometry and deduced from the nucleotide sequence of the cDNA encoding for the enzyme. The electrospray mass spectral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a467f8ddcc07ee14b8f9c6de9d4dad4
https://pubmed.ncbi.nlm.nih.gov/7527260
https://pubmed.ncbi.nlm.nih.gov/7527260