Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Hans J Stauss"'
Autor:
Rebecca ePike, Niclas eThomas, Sarita eWorkman, Lyn eAmbrose, David eGuzman, Shivajanani eSivakumaran, Margaret eJohnson, Douglas eThorburn, Mark Alan Harber, Benny eChain, Hans J Stauss
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
We tested whether multi-parameter immune phenotyping before or after renal transplantation can predict the risk of rejection episodes. Blood samples collected before, and weekly for 3 months after transplantation were analyzed by multi-parameter flow
Externí odkaz:
https://doaj.org/article/e30faa81520b42789220e45fe35928ee
Publikováno v:
PLoS ONE, Vol 2, Iss 4, p e353 (2007)
Most tumor-associated antigens (TAA) currently used for immunotherapy of cancer are also expressed in normal tissues, which may induce tolerance and impair T cell-mediated immunity. However, there is limited information about how physiological expres
Externí odkaz:
https://doaj.org/article/61e8c3d9adfd4ab79995e7f84fbc53ab
Autor:
Abdullah Degirmencay, Sharyn Thomas, Angelika Holler, Samuel Burgess, Emma C. Morris, Hans J. Stauss
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The expression levels of TCRs on the surface of human T cells define the avidity of TCR-HLA/peptide interactions. In this study, we have explored which components of the TCR-CD3 complex are involved in determining the surface expression levels of TCR
Externí odkaz:
https://doaj.org/article/8025343ede7741d989be0574485bfd42
Autor:
Yiya Zhong, Hans J. Stauss
Publikováno v:
Cells, Vol 13, Iss 10, p 797 (2024)
Multiple sclerosis is an autoinflammatory condition that results in damage to myelinated neurons in affected patients. While disease-modifying treatments have been successful in slowing the progression of relapsing–remitting disease, most patients
Externí odkaz:
https://doaj.org/article/2a253f7982d34acfaf9027cac3b32ad8
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T cell receptor (TCR) gene modified T cells are a promising form of adoptive cellular therapy against human malignancies and viral infections. Since the first human clinical trial was carried out in 2006, several strategies have been developed to imp
Externí odkaz:
https://doaj.org/article/245a33148092493bbaf9c3a60352e6f0
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Autor:
Nathalie M. Schmidt, Peter A. C. Wing, Mariana O. Diniz, Laura J. Pallett, Leo Swadling, James M. Harris, Alice R. Burton, Anna Jeffery-Smith, Nekisa Zakeri, Oliver E. Amin, Stephanie Kucykowicz, Mirjam H. Heemskerk, Brian Davidson, Tim Meyer, Joe Grove, Hans J. Stauss, Ines Pineda-Torra, Clare Jolly, Elizabeth C. Jury, Jane A. McKeating, Mala K. Maini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Shared metabolic pathways could allow simultaneous manipulation of T cells, viruses and tumours. Here the authors show targeting cholesterol esterification restrains hepatitis B in vitro, whilst bolstering exhausted antigen-specific T cell responses
Externí odkaz:
https://doaj.org/article/80c091a62a0e452aadda8e67b452162c
Autor:
Sara Campinoti, Asllan Gjinovci, Roberta Ragazzini, Luca Zanieri, Linda Ariza-McNaughton, Marco Catucci, Stefan Boeing, Jong-Eun Park, John C. Hutchinson, Miguel Muñoz-Ruiz, Pierluigi G. Manti, Gianluca Vozza, Carlo E. Villa, Demetra-Ellie Phylactopoulos, Constance Maurer, Giuseppe Testa, Hans J. Stauss, Sarah A. Teichmann, Neil J. Sebire, Adrian C. Hayday, Dominique Bonnet, Paola Bonfanti
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The thymus is essential for T cell maturation and selection, and thymic defects result in severe immune problems. Here the authors identify a thymus cell population that is expandable in vitro, and can repopulate natural thymic matrix to generate tis
Externí odkaz:
https://doaj.org/article/c841855db99048c2a21529c2cdc906b1
Autor:
Sharyn Thomas, Fiyaz Mohammed, Rogier M. Reijmers, Annemarie Woolston, Theresa Stauss, Alan Kennedy, David Stirling, Angelika Holler, Louisa Green, David Jones, Katherine K. Matthews, David A. Price, Benjamin M. Chain, Mirjam H. M. Heemskerk, Emma C. Morris, Benjamin E. Willcox, Hans J. Stauss
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues
Externí odkaz:
https://doaj.org/article/b91ffe9fd06f4dd8ae5b0aa7c12c5d8e
Autor:
Chloe Rees-Spear, Luke Muir, Sarah A. Griffith, Judith Heaney, Yoann Aldon, Jonne L. Snitselaar, Peter Thomas, Carl Graham, Jeffrey Seow, Nayung Lee, Annachiara Rosa, Chloe Roustan, Catherine F. Houlihan, Rogier W. Sanders, Ravindra K. Gupta, Peter Cherepanov, Hans J. Stauss, Eleni Nastouli, Katie J. Doores, Marit J. van Gils, Laura E. McCoy
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108890- (2021)
Summary: Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the viral entry protein, spike. Because new SARS-CoV-2 variants are
Externí odkaz:
https://doaj.org/article/78e75387f25c4488ad981560e9ef8e93
Autor:
Hans J. Stauss, Maxine G. B. Tran
Publikováno v:
Cells, Vol 9, Iss 12, p 2567 (2020)
Adoptive immunotherapy with gene-engineered T cells has provided new treatment options for cancer patients [...]
Externí odkaz:
https://doaj.org/article/ec9cd82c4d3f44e4aa7a558fbcaab2ae