Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hans Jürgen Sass"'
Autor:
Rafael Van den Bergh, Sébastien Morin, Hans Jürgen Sass, Stephan Grzesiek, Marc Vekemans, Eric Florence, Huyen Thanh Thi Tran, Rosina Gabriel Imiru, Leo Heyndrickx, Guido Vanham, Patrick De Baetselier, Geert Raes
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35074 (2012)
BACKGROUND: The immune system exerts a diversifying selection pressure on HIV through cellular, humoral and innate mechanisms. This pressure drives viral evolution throughout infection. A better understanding of the natural immune pressure on the vir
Externí odkaz:
https://doaj.org/article/1e5e69fa4e0e4b3584f7a87f9ad4d635
Publikováno v:
Journal of biomolecular NMR
The chemokine receptor CCR5 belongs to the class of G protein-coupled receptors. Besides its role in leukocyte trafficking, it is also the major HIV-1 coreceptor and hence a target for HIV-1 entry inhibitors. Here, we report Escherichia coli expressi
Autor:
Stephan Grzesiek, Hans-Jürgen Sass
Publikováno v:
Current Opinion in Structural Biology. 19:585-595
Biomolecular structure provides the framework for dynamics and function. However, the information of more than 50000 protein and nucleic acid structures solved today has not yet yielded enough insight such that function could be predicted from struct
Publikováno v:
Angewandte Chemie. 120:10018-10022
Autor:
Martin G. Allan, Pernille Rose Jensen, Charles J. Thompson, Judith Habazettl, Stephan Grzesiek, Hans-Jürgen Sass
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(51)
TipA is a transcriptional regulator found in diverse bacteria. It constitutes a minimal autoregulated multidrug resistance system against numerous thiopeptide antibiotics. Here we report the structures of its drug-binding domain TipAS in complexes wi
Autor:
Martin G. Allan, Daniel Häussinger, Hans-Jürgen Sass, Stephan Grzesiek, Sebastian Meier, Jan D. Kahmann, Florence Cordier, Pernille Rose Jensen
Publikováno v:
Pure and Applied Chemistry. 77:1409-1424
High-resolution nuclear magnetic resonance (NMR) has emerged as one of the most versatile tools for the quantitative study of structure, kinetics, and thermodynamics of biomolecules and their interactions at atomic resolution. Traditionally, nuclear
Autor:
Martin G. Allan, Hans-Jürgen Sass, Jan D. Kahmann, Haruo Seto, Charles J. Thompson, Stephan Grzesiek
Publikováno v:
The EMBO Journal. 22:1824-1834
The TipAL protein, a bacterial transcriptional regulator of the MerR family, is activated by numerous cyclic thiopeptide antibiotics. Its C-terminal drug-binding domain, TipAS, defines a subfamily of broadly distributed bacterial proteins including M
Autor:
Daniel Häussinger, Jürgen Engel, Olivier Pertz, Stephan Grzesiek, Hans-Jürgen Sass, Thomas Ahrens
Publikováno v:
Journal of Molecular Biology. 324:823-839
Cadherins are calcium-dependent cell surface proteins that mediate homophilic cellular adhesion. The calcium-induced oligomerization of the N-terminal two domains of epithelial cadherin (ECAD12) was followed by NMR spectroscopy in solution over a lar
Publikováno v:
Journal of Biomolecular NMR. 21:275-280
We have recently shown that an energy penalty for the incorporation of residual tensorial constraints into molecular structure calculations can be formulated without the explicit knowledge of the Saupe orientation tensor (Moltke and Grzesiek, J. Biom
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1460(1):192-203
A wealth of information has been gathered during the past decades that water molecules do play an important role in the structure, dynamics, and function of bacteriorhodopsin (bR) and purple membrane. Light-induced structural alterations in bR as det