Zobrazeno 1 - 10
of 49 351
pro vyhledávání: '"Hans J"'
Autor:
Yash Patel, Jean Shin, Eeva Sliz, Ariana Tang, Aniket Mishra, Rui Xia, Edith Hofer, Hema Sekhar Reddy Rajula, Ruiqi Wang, Frauke Beyer, Katrin Horn, Max Riedl, Jing Yu, Henry Völzke, Robin Bülow, Uwe Völker, Stefan Frenzel, Katharina Wittfeld, Sandra Van der Auwera, Thomas H. Mosley, Vincent Bouteloup, Jean-Charles Lambert, Geneviève Chêne, Carole Dufouil, Christophe Tzourio, Jean-François Mangin, Rebecca F. Gottesman, Myriam Fornage, Reinhold Schmidt, Qiong Yang, Veronica Witte, Markus Scholz, Markus Loeffler, Gennady V. Roshchupkin, M. Arfan Ikram, Hans J. Grabe, Sudha Seshadri, Stephanie Debette, Tomas Paus, Zdenka Pausova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract White matter hyperintensities index structural abnormalities in the cerebral white matter, including axonal damage. The latter may promote atrophy of the cerebral cortex, a key feature of dementia. Here, we report a study of 51,065 individua
Externí odkaz:
https://doaj.org/article/bf9509bdebd5484ea27088d73ad6ccb8
Autor:
Helena Bui, Amena Keshawarz, Mengyao Wang, Mikyeong Lee, Scott M. Ratliff, Lisha Lin, Kira S. Birditt, Jessica D. Faul, Annette Peters, Christian Gieger, Thomas Delerue, Sharon L. R. Kardia, Wei Zhao, Xiuqing Guo, Jie Yao, Jerome I. Rotter, Yi Li, Xue Liu, Dan Liu, Juliana F. Tavares, Gökhan Pehlivan, Monique M. B. Breteler, Irma Karabegovic, Carolina Ochoa-Rosales, Trudy Voortman, Mohsen Ghanbari, Joyce B. J. van Meurs, Mohamed Kamal Nasr, Marcus Dörr, Hans J. Grabe, Stephanie J. London, Alexander Teumer, Melanie Waldenberger, David R. Weir, Jennifer A. Smith, Daniel Levy, Jiantao Ma, Chunyu Liu
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Epigenome‐wide association studies have identified multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases. This study aimed to test the hypothesi
Externí odkaz:
https://doaj.org/article/778cf18febfb469f98f4928da01f6554
Autor:
Junhao Wen, Zhijian Yang, Ilya M. Nasrallah, Yuhan Cui, Guray Erus, Dhivya Srinivasan, Ahmed Abdulkadir, Elizabeth Mamourian, Gyujoon Hwang, Ashish Singh, Mark Bergman, Jingxuan Bao, Erdem Varol, Zhen Zhou, Aleix Boquet-Pujadas, Jiong Chen, Arthur W. Toga, Andrew J. Saykin, Timothy J. Hohman, Paul M. Thompson, Sylvia Villeneuve, Randy Gollub, Aristeidis Sotiras, Katharina Wittfeld, Hans J. Grabe, Duygu Tosun, Murat Bilgel, Yang An, Daniel S. Marcus, Pamela LaMontagne, Tammie L. Benzinger, Susan R. Heckbert, Thomas R. Austin, Lenore J. Launer, Mark Espeland, Colin L. Masters, Paul Maruff, Jurgen Fripp, Sterling C. Johnson, John C. Morris, Marilyn S. Albert, R. Nick Bryan, Susan M. Resnick, Luigi Ferrucci, Yong Fan, Mohamad Habes, David Wolk, Li Shen, Haochang Shou, Christos Davatzikos
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Alzheimer’s disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain a
Externí odkaz:
https://doaj.org/article/56d631e8319148739bce0f8e8b35d005
Autor:
Brecht Droesbeke, Nadège Balmelle, Ann Brigitte Cay, Shaojie Han, Dayoung Oh, Hans J. Nauwynck, Marylène Tignon
Publikováno v:
Microbiology Research, Vol 15, Iss 3, Pp 1690-1708 (2024)
African Swine Fever (ASF) is a devastating viral hemorrhagic disease that causes high morbidity and mortality in domestic pigs and wild boars, severely impacting the swine industry. The etiologic agent, African Swine Fever virus (ASFV), mainly infect
Externí odkaz:
https://doaj.org/article/ca604ebe4b174f849813fa524f6777d6
Autor:
Shrestha Ghosh, Mileena T. Nguyen, Ha Eun Choi, Maximilian Stahl, Annemarie Luise Kühn, Sandra Van der Auwera, Hans J. Grabe, Henry Völzke, Georg Homuth, Samuel A. Myers, Cory M. Hogaboam, Imre Noth, Fernando J. Martinez, Gregory A. Petsko, Laurie H. Glimcher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Telomere shortening is a prominent hallmark of aging and is emerging as a characteristic feature of Myelodysplastic Syndromes (MDS) and Idiopathic Pulmonary Fibrosis (IPF). Optimal telomerase activity prevents progressive shortening of telom
Externí odkaz:
https://doaj.org/article/acac83437afc458ea79c24761644c96b
Publikováno v:
Humanities & Social Sciences Communications, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract We examine the prevalence of illiberal attitudes among aspiring state legislative candidates in the United States. While extensive research has questioned underlying levels of support for liberal democratic principles among the general publi
Externí odkaz:
https://doaj.org/article/bcaf8b40c73147f398e4bd861dbe19a5
Autor:
Paul Kupke, Jordi Yang Zhou, Gunther Glehr, Paloma Riquelme, Lena Scheibert, Akinbami Adenugba, Hans J. Schlitt, Edward K. Geissler, Jens M. Werner, James A. Hutchinson
Publikováno v:
Heliyon, Vol 10, Iss 23, Pp e40841- (2024)
Background: Routine liver function tests capture information about the metabolic and inflammatory condition of the liver, but we lack sensitive biomarkers of early hepatocyte stress. In humans, soluble CD46 (sCD46) levels in blood were recently ident
Externí odkaz:
https://doaj.org/article/719573a31faa4828a8e9d24460b5a8e3
Autor:
Lisa A. King, Myrthe Veth, Victoria Iglesias-Guimarais, Iris Blijdorp, Jan Kloosterman, André N. Vis, Rob C. Roovers, David Lutje Hulsik, Thilo Riedl, Anton E.P. Adang, Paul W.H.I. Parren, Pauline M. van Helden, Tanja D. de Gruijl, Hans J. van der Vliet
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111289- (2024)
Summary: Vγ9Vδ2 T cells constitute a homogeneous effector T cell population that lyses tumors of different origin, including the prostate. We generated a bispecific T cell engager (bsTCE) to direct Vγ9Vδ2 T cells to PSMA+ prostate cancer (PCa) ce
Externí odkaz:
https://doaj.org/article/3851d95388e04a9c8291c66dc23ead05
Autor:
Sietske C.M.W. van Nassau, Helene R. Voogdt-Pruis, Vincent M.W. de Jong, Hans-Martin Otten, Liselot B. Valkenburg-van Iersel, Bas J. Swarte, Tineke E. Buffart, Hans J. Pruijt, Leonie J. Mekenkamp, Miriam Koopman, Anne M. May
Publikováno v:
PEC Innovation, Vol 4, Iss , Pp 100300- (2024)
Objective: To improve sustainability of a patient decision aid for systemic treatment of metastatic colorectal cancer, we evaluated real-world experiences and identified ways to optimize decision aid content and future implementation. Methods: Semi-s
Externí odkaz:
https://doaj.org/article/7ff0631d8f624b958ba577f5a3ab8d28
Autor:
Lotte Bakkerus, Beatriz Subtil, Hetty J. Bontkes, Elske C. Gootjes, Martine Reijm, Manon Vullings, Kiek Verrijp, John-Melle Bokhorst, Carmen Woortman, Iris D. Nagtegaal, Marianne A. Jonker, Hans J. van der Vliet, Cornelis Verhoef, Mark A.J. Gorris, I. Jolanda M. de Vries, Tanja D. de Gruijl, Henk M.W. Verheul, Tineke E. Buffart, Daniele V. F. Tauriello
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Colorectal cancer (CRC) raises considerable clinical challenges, including a high mortality rate once the tumor spreads to distant sites. At this advanced stage, more accurate prediction of prognosis and treatment outcome is urgently needed. The role
Externí odkaz:
https://doaj.org/article/d840e76947914521ba035fcfccc6eb05