Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hans Hombauer"'
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Reyes et al. identified and characterized dominant mutations in the MutL homolog MLH2 (in S. cerevisiae) and PMS1 (in humans) causing an increased mutator phenotype. Based on their findings, they propose that Mlh2/hPMS1-Mlh1 mutant complexes can act
Externí odkaz:
https://doaj.org/article/ca8b2b28c21f4262a1051bb3ba633b91
Autor:
Yaqing Zhang, David Kuster, Tobias Schmidt, Daniel Kirrmaier, Gabriele Nübel, David Ibberson, Vladimir Benes, Hans Hombauer, Michael Knop, Andres Jäschke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
NAD (nicotinamide adenine dinucleotide) acts as a non-canonical RNA cap structure in bacteria and eukaryotes. Here the authors demonstrate the whole landscape of budding yeast NAD-RNAs which are subject to diverse surveillance pathways, suggesting th
Externí odkaz:
https://doaj.org/article/cb1a8be4555f41cba2402ba4c1a9d430
Publikováno v:
Cell Reports, Vol 4, Iss 1, Pp 174-188 (2013)
DNA damage activates checkpoint kinases that induce several downstream events, including widespread changes in transcription. However, the specific connections between the checkpoint kinases and downstream transcription factors (TFs) are not well und
Externí odkaz:
https://doaj.org/article/41d04e34ebda42168b3913bb56be7ccf
Autor:
Christopher S Campbell, Hans Hombauer, Anjana Srivatsan, Nikki Bowen, Kerstin Gries, Arshad Desai, Christopher D Putnam, Richard D Kolodner
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004327 (2014)
In Saccharomyces cerevisiae, the essential mismatch repair (MMR) endonuclease Mlh1-Pms1 forms foci promoted by Msh2-Msh6 or Msh2-Msh3 in response to mispaired bases. Here we analyzed the Mlh1-Mlh2 complex, whose role in MMR has been unclear. Mlh1-Mlh
Externí odkaz:
https://doaj.org/article/495a2c90b0c046fe8c47ec0ea2fa3979
Autor:
Catherine E Smith, Marc L Mendillo, Nikki Bowen, Hans Hombauer, Christopher S Campbell, Arshad Desai, Christopher D Putnam, Richard D Kolodner
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003869 (2013)
Lynch syndrome (hereditary nonpolypsis colorectal cancer or HNPCC) is a common cancer predisposition syndrome. Predisposition to cancer in this syndrome results from increased accumulation of mutations due to defective mismatch repair (MMR) caused by
Externí odkaz:
https://doaj.org/article/16a0b87dd41042529c76ae4f33b5ed60
Autor:
Hans Hombauer, David Weismann, Ingrid Mudrak, Claudia Stanzel, Thomas Fellner, Daniel H Lackner, Egon Ogris
Publikováno v:
PLoS Biology, Vol 5, Iss 6, p e155 (2007)
Protein phosphatase 2A (PP2A) is a prime example of the multisubunit architecture of protein serine/threonine phosphatases. Until substrate-specific PP2A holoenzymes assemble, a constitutively active, but nonspecific, catalytic C subunit would consti
Externí odkaz:
https://doaj.org/article/ae192ab772a94c3e87f642b6b110601d
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Inactivating mutations affecting key mismatch repair (MMR) components lead to microsatellite instability (MSI) and cancer. However, a number of patients with MSI-tumors do not present alterations in classical MMR genes. Here we discovered that specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1bed393c7d33d1176ef4aa89473d21
https://doi.org/10.1038/s42003-020-01481-4
https://doi.org/10.1038/s42003-020-01481-4
Autor:
David Ibberson, Hans Hombauer, Yaqing Zhang, Gabriele Nübel, David Kuster, Michael Knop, Andres Jäschke, Tobias T. Schmidt, Daniel Kirrmaier, Vladimir Benes
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The ubiquitous redox coenzyme nicotinamide adenine dinucleotide (NAD) acts as a non-canonical cap structure on prokaryotic and eukaryotic ribonucleic acids. Here we find that in budding yeast, NAD-RNAs are abundant (>1400 species), short (
NAD (
NAD (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2613e1b221c56371571710e70cd40a1
Autor:
Sushma Sharma, Tobias T. Schmidt, Brian Luke, Anna Kolodziejczak, Tina Wagner, Andrei Chabes, Anders Hofer, Gloria X Reyes, Hans Hombauer
Publikováno v:
Nucleic Acids Research
The accumulation of mutations is frequently associated with alterations in gene function leading to the onset of diseases, including cancer. Aiming to find novel genes that contribute to the stability of the genome, we screened the Saccharomyces cere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3957913e0d1f68da2d4f2bb7a1fa6f51
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170313
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170313
Autor:
Hans Hombauer, Maike Gross, Andrei Chabes, Sushma Sharma, Gloria X Reyes, Kerstin Gries, Jui-Hung Yuan, Rebecca C. Wade, Boyu Zhao, Tobias T. Schmidt
Publikováno v:
Nucleic Acids Research
The balance and the overall concentration of intracellular deoxyribonucleoside triphosphates (dNTPs) are important determinants of faithful DNA replication. Despite the established fact that changes in dNTP pools negatively influence DNA replication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d592d25edb43717c08ca66aca1b16fa5
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154182
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154182