Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hans Hamersma"'
Autor:
Marcel van Duin, Rita Azevedo, Hans Hamersma, Diep Vu-Pham, Arthur Oubrie, Scott J. Lusher, Rolien Bosch, Bert Kazemier, Hans C.A. Raaijmakers, Jacob de Vlieg, Koen J. Dechering, Ross McGuire
Publikováno v:
Journal of Biological Chemistry, 287, 20333-20343
Journal of Biological Chemistry, 287, 24, pp. 20333-20343
Journal of Biological Chemistry, 287, 24, pp. 20333-20343
Contains fulltext : 103894.pdf (Publisher’s version ) (Open Access) We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed profile PR modulators whose functional activity results from two differing molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5603237fee702c88c44068b45f204787
https://doi.org/10.1074/jbc.m111.308403
https://doi.org/10.1074/jbc.m111.308403
Autor:
Hans Hamersma, Johannes Bernardus Maria Rewinkel, Paul Peter Marie Antonius Dols, Hans Lucas, Cor W. Kuil, Pedro H. H. Hermkens, Lourdes Ollero, Folmer Brigitte Johanna Bernita
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1461-1467
We have developed a new class of progesterone receptor agonists having a tetracyclic dibenzo-oxazepine structure 1. In this paper, the synthesis and structure-activity relationships of this new class are described. This work led to the identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5973f6006832490d35f0f6a886cb529e
https://doi.org/10.1016/j.bmcl.2007.12.065
https://doi.org/10.1016/j.bmcl.2007.12.065
Publikováno v:
Journal of Combinatorial Chemistry. 1:307-316
In combinatorial chemistry, the time-consuming step is optimizing the reaction conditions rather than the actual preparation of the library. We propose a new combinatorial strategy, “functional group transformation”, which permits construction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d179d6f87eb3c3583552e062e8bd4ce
https://doi.org/10.1021/cc990003b
https://doi.org/10.1021/cc990003b
Publikováno v:
Journal of Chemical Information and Computer Sciences. 39:1-10
It is now common practice in the pharmaceutical industry to use molecular diversity selection methods. With the advent of high throughput screening and combinatorial chemistry, compounds must be rationally selected from databases of hundreds of thous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f23c9af25a7f5aa61b271eea1f75c494
https://doi.org/10.1021/ci980109e
https://doi.org/10.1021/ci980109e
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2925-2928
11,13-Ethanopregnanes were prepared to assess the influence of the bending of the steroid skeleton on progestagenic activity. It was demonstrated that, contrary to previous assumptions, upward bending of the A ring has little overall effect on the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eb235ce25e90ffaeddf4996a5135aa9
https://doi.org/10.1016/s0960-894x(97)10113-5
https://doi.org/10.1016/s0960-894x(97)10113-5
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2929-2934
As 3-Ketodesogestrel and Gestodene differ in the conformation of the 13-ethyl group, a series of progestagens was devised in which this conformation is fixed. Thus, both epimers of a steroid with a methyl-substituted 11,13-ethano bridge were prepared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::991f2bd97c6cb4c6a4af41152ba6f1ed
https://doi.org/10.1016/s0960-894x(97)10112-3
https://doi.org/10.1016/s0960-894x(97)10112-3
Publikováno v:
Tetrahedron Letters. 35:335-338
Reaction of 4-pentynyltriphenylphosphonium bromide 2 with oestrone methyl ether in the presence of potassium tert -butylate produced a spirobicyclo[3.1.0]hexane rather than the anticipated Wittig product. The reaction appears to be general for pinaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17376118d8b6829999bd426fc5b08b49
https://doi.org/10.1016/s0040-4039(00)76546-4
https://doi.org/10.1016/s0040-4039(00)76546-4
Publikováno v:
ChemInform. 25
Reaction of 4-pentynyltriphenylphosphonium bromide 2 with oestrone methyl ether in the presence of potassium tert -butylate produced a spirobicyclo[3.1.0]hexane rather than the anticipated Wittig product. The reaction appears to be general for pinaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1807c0242caa76e60ff0107773163a6f
https://doi.org/10.1002/chin.199418041
https://doi.org/10.1002/chin.199418041
Publikováno v:
ChemInform. 29
As 3-Ketodesogestrel and Gestodene differ in the conformation of the 13-ethyl group, a series of progestagens was devised in which this conformation is fixed. Thus, both epimers of a steroid with a methyl-substituted 11,13-ethano bridge were prepared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a37e0c2ec7154fc42aa42433f22ba154
https://doi.org/10.1002/chin.199812169
https://doi.org/10.1002/chin.199812169
Publikováno v:
ChemInform. 29
11,13-Ethanopregnanes were prepared to assess the influence of the bending of the steroid skeleton on progestagenic activity. It was demonstrated that, contrary to previous assumptions, upward bending of the A ring has little overall effect on the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c90e93a7a54f79bcad6437acf80fba8
https://doi.org/10.1002/chin.199811216
https://doi.org/10.1002/chin.199811216