Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Hans Häcker"'
Autor:
Vanessa Redecke, Kazuki Tawaratsumida, Erin T. Larragoite, Elizabeth S. C. P. Williams, Vicente Planelles, Adam M. Spivak, Lincoln Hirayama, Marc Elgort, Shane Swenson, Rick Smith, Bryan Worthen, Russ Zimmerman, Patricia Slev, Ben Cahoon, Mark Astill, Hans Häcker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Diagnostic tests that detect antibodies (AB) against SARS-CoV-2 for evaluation of seroprevalence and guidance of health care measures are important tools for managing the COVID-19 pandemic. Current tests have certain limitations with regard
Externí odkaz:
https://doaj.org/article/1655f619167244489c5e59a7785e3869
Autor:
Antonella Russo, Hendrik Schürmann, Matthias Brandt, Katja Scholz, Anna Livia L. Matos, David Grill, Julian Revenstorff, Maximilian Rembrink, Meike von Wulffen, Lena Fischer‐Riepe, Peter J. Hanley, Hans Häcker, Monika Prünster, Francisco Sánchez‐Madrid, Sven Hermann, Luisa Klotz, Volker Gerke, Timo Betz, Thomas Vogl, Johannes Roth
Publikováno v:
Advanced Science, Vol 9, Iss 36, Pp n/a-n/a (2022)
Abstract Mechanisms keeping leukocytes distant of local inflammatory processes in a resting state despite systemic release of inflammatory triggers are a pivotal requirement for avoidance of overwhelming inflammation but are ill defined. Dimers of th
Externí odkaz:
https://doaj.org/article/436a845c56a94e71958ce48320f05a72
Autor:
Sara Elhag, Christopher Stremmel, Annette Zehrer, Josefine Plocke, Roman Hennel, Michaela Keuper, Clarissa Knabe, Julia Winterhalter, Vanessa Gölling, Lukas Tomas, Tobias Weinberger, Maximilian Fischer, Lulu Liu, Franziska Wagner, Michael Lorenz, Konstantin Stark, Hans Häcker, Marc Schmidt-Supprian, Uwe Völker, Martin Jastroch, Kirsten Lauber, Tobias Straub, Barbara Walzog, Elke Hammer, Christian Schulz
Publikováno v:
Cells, Vol 10, Iss 12, p 3564 (2021)
Background: Tissue-resident macrophages have mixed developmental origins. They derive in variable extent from yolk sac (YS) hematopoiesis during embryonic development. Bone marrow (BM) hematopoietic progenitors give rise to tissue macrophages in post
Externí odkaz:
https://doaj.org/article/e412d572581a422fa50461043bf73b94
Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.
Autor:
Matthias Klein, Matthijs C Brouwer, Barbara Angele, Madelijn Geldhoff, Gabriel Marquez, Rosa Varona, Georg Häcker, Helga Schmetzer, Hans Häcker, Sven Hammerschmidt, Arie van der Ende, Hans-Walter Pfister, Diederik van de Beek, Uwe Koedel
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93057 (2014)
We previously identified CCL20 as an early chemokine in the cerebrospinal fluid (CSF) of patients with pneumococcal meningitis but its functional relevance was unknown. Here we studied the role of CCL20 and its receptor CCR6 in pneumococcal meningiti
Externí odkaz:
https://doaj.org/article/d46a91c1d31c465a9e2267d927a34599
Publikováno v:
PLoS Pathogens, Vol 9, Iss 11, p e1003727 (2013)
Streptococcus pneumoniae infection is a leading cause of bacterial pneumonia, sepsis and meningitis and is associated with high morbidity and mortality. Type I interferon (IFN-I), whose contribution to antiviral and intracellular bacterial immunity i
Externí odkaz:
https://doaj.org/article/2fba4f496af54d92a578a2b456dc1feb
Autor:
Sean P Garrison, Justin A Thornton, Hans Häcker, Richard Webby, Jerold E Rehg, Evan Parganas, Gerard P Zambetti, Elaine I Tuomanen
Publikováno v:
PLoS Pathogens, Vol 6, Iss 12, p e1001240 (2010)
Disruption of p53/Puma-mediated apoptosis protects against lethality due to DNA damage. Here we demonstrate the unexpected requirement of the pro-apoptotic p53-target gene Puma to mount a successful innate immune response to bacterial sepsis. Puma⁻
Externí odkaz:
https://doaj.org/article/7b627385eab54f24b899f8c3faeb10c6
Autor:
Uwe Koedel, Tobias Frankenberg, Susanne Kirschnek, Bianca Obermaier, Hans Häcker, Robert Paul, Georg Häcker
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000461 (2009)
During acute bacterial infections such as meningitis, neutrophils enter the tissue where they combat the infection before they undergo apoptosis and are taken up by macrophages. Neutrophils show pro-inflammatory activity and may contribute to tissue
Externí odkaz:
https://doaj.org/article/f55d275d499945afaee31f3e95b9d1c1
Autor:
Hans Häcker
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c065783ec4c58564f426765bdd0dd995
https://doi.org/10.1007/978-1-0716-2938-3_7
https://doi.org/10.1007/978-1-0716-2938-3_7
A phospho-tyrosine-based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity
Autor:
Kazuki Tawaratsumida, Vanessa Redecke, Ruiqiong Wu, Jeeba Kuriakose, Jill J. Bouchard, Tanja Mittag, Brian K. Lohman, Ashutosh Mishra, Anthony A. High, Hans Häcker
Publikováno v:
Science advances. 8(27)
Toll-like receptors (TLRs) recognize pathogen- and host-derived factors and control immune responses via the adaptor protein MyD88 and members of the interferon regulatory transcription factor (IRF) family. IRFs orchestrate key effector functions, in
Publikováno v:
Journal of visualized experiments : JoVE. (181)
Dendritic cells (DCs) are important antigen-presenting cells that connect innate and adaptive immune responses. DCs are heterogeneous and can be divided into conventional DCs (cDCs) and plasmacytoid DCs (pDCs). cDCs specializes in presenting antigens