Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Hans Grunicke"'
Autor:
Marcel Jenny, Wolfgang Schwaiger, Florian Ueberall, Martin Spitaler, James Mwanjewe, Hans Grunicke
Publikováno v:
Advances in Enzyme Regulation. 43:213-228
Autor:
Wolfgang Schwaiger, Franz Hochholdinger, Gottfried Baier, Sonja Kampfer, Richard G. Pestell, Hans Grunicke, Florian Überall, Michaela Windegger
Publikováno v:
Journal of Biological Chemistry. 276:42834-42842
Transcriptional activation of the cyclin D1 by oncogenic Ras appears to be mediated by several pathways leading to the activation of multiple transcription factors which interact with distinct elements of the cyclin D1 promoter. The present investiga
Autor:
Michaela Windegger, Martin Spitaler, Sonja Kampfer, Florian Überall, James Mwanjewe, Hans Grunicke, Markus Geiger, Maria Ebner, Johann Hofmann
Publikováno v:
Biochemical Journal. 359:211-217
The activation of phospholipase D (PLD) by transforming Ras is well documented. Although two distinct PLD isoforms, PLD1 and PLD2, have been cloned from mammalian cells, it has remained unclear whether both isoenzymes are activated by Ras and, if thi
Autor:
Hans Grunicke, Maria Rybczynska, Johann Hofmann, Martin Spitaler, Günther Boeck, Norbert G Knebel
Publikováno v:
Biochemical Pharmacology. 62:765-772
We investigated endocytosis activity, uptake of miltefosine (hexadecylphosphocholine), phospholipid and cholesterol content, the cell cycle, and apoptosis in 13 tumor cell lines (MCF7, MCF7/ADR, KB-3-1, KB-8-5, KB-C1, HeLa, HeLa-MDR1-G185, HeLa-MDR1-
Autor:
P Lu, Johann Hofmann, Martin Spitaler, R Liu, Emmanuelle Steinfels, A. Di Pietro, Frances J. Sharom, Hans Grunicke, Maria Rybczynska
Publikováno v:
British Journal of Cancer
Miltefosine (hexadecylphosphocholine) is used for topical treatment of breast cancers. It has been shown previously that a high percentage of breast carcinomas express MDR1 or MRP. We investigated the sensitivity of MDR1 -expressing cells to treatmen
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 125:182-186
The composition of the H1° histone subfractions was examined in different rat and mouse tissues. Using reverse-phase HPLC and hydrophilic-interaction liquid chromatography we have found that the relative proportions of all four forms of H1° differ
Autor:
Andreas Villunger, Sonja Kampfer, Florian Überall, Hans Grunicke, Gottfried Baier, Karina Hellbert, James Mwanjewe, Martin Spitaler, Karl Maly, Gabriele Baier-Bitterlich
Publikováno v:
The Journal of Cell Biology
Expression of transforming Ha-Ras L61 in NIH3T3 cells causes profound morphological alterations which include a disassembly of actin stress fibers. The Ras-induced dissolution of actin stress fibers is blocked by the specific PKC inhibitor GF109203X
Autor:
Garth Powis, Hans Grunicke
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 124:462-469
Autor:
Gottfried Baier, Andreas Villunger, Karina Hellbert, Wolfgang Doppler, Florian Überall, Sonja Kampfer, Hans Grunicke
Publikováno v:
The EMBO Journal. 17:4046-4055
The implication of protein kinase C (PKC) isoforms cPKC-alpha, nPKC-epsilon, aPKC-lambda and aPKC-zeta in the transcriptional activation of a c-fos promoter-driven CAT-reporter construct by transforming Ha-Ras has been investigated. This was achieved
Autor:
Wolfgang Hilbe, Urs Regenass, C. Ludescher, Maria Rybczynska, Martin Spitaler, I. Utz, Johann Hofmann, Hans Grunicke
Publikováno v:
International Journal of Cancer. 77:64-69
It has been shown previously that the staurosporine derivative CGP 41251, a specific inhibitor of protein kinase C (IC50 = 50 nM), exhibits antitumor activity and reverses mdr1-mediated multidrug resistance. At present, the compound is evaluated as a