Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Hans Gaus"'
Autor:
Martina H. Lundberg Slingsby, Prakrith Vijey, I-Ting Tsai, Harvey Roweth, Genevieve Couldwell, Adrian R. Wilkie, Hans Gaus, Jazana M. Goolsby, Ross Okazaki, Brooke E. Terkovich, John W. Semple, Jonathan N. Thon, Scott P. Henry, Padmakumar Narayanan, Joseph E. Italiano Jr.
Publikováno v:
Haematologica, Vol 107, Iss 2 (2021)
Antisense oligonucleotides (ASO) are DNA-based, disease-modifying drugs. Clinical trials with 2'-O-methoxyethyl (2’MOE) ASO have shown dose- and sequence-specific lowering of platelet counts according to two phenotypes. Phenotype 1 is a moderate (b
Externí odkaz:
https://doaj.org/article/ac735069e61e406db2676efc4ab4c007
Autor:
Tamilselvan Rajasekaran, Graeme C. Freestone, Rodrigo Galindo-Murillo, Barbara Lugato, Hans Gaus, Michael T. Migawa, Eric. E. Swayze, Thomas E. Cheatham, Punit P. Seth, Stephen Hanessian
Publikováno v:
The Journal of Organic Chemistry. 88:3599-3614
Autor:
Tamilselvan Rajasekaran, Graeme C. Freestone, Rodrigo Galindo-Murillo, Barbara Lugato, Lorena Rico, Juan C. Salinas, Hans Gaus, Michael T. Migawa, Eric E. Swayze, Thomas E. Cheatham, Stephen Hanessian, Punit P. Seth
Publikováno v:
J Am Chem Soc
Journal of the American Chemical Society, vol 144, iss 4
Journal of the American Chemical Society, vol 144, iss 4
The binding affinity of therapeutic oligonucleotides (ONs) for their cognate RNA is determined by the rates of association (ka) and dissociation (kd). Single-stranded ONs are highly flexible and can adopt multiple conformations in solution, some of w
Autor:
Cheryl L De Hoyos, Thazha P. Prakash, Xue-hai Liang, Wen Shen, Hans Gaus, Stanley T. Crooke, Jinghua Yu, Andres Berdeja, Punit P. Seth
Publikováno v:
ACS Med Chem Lett
[Image: see text] Site-specific incorporation of 2′-modifications and neutral linkages in the deoxynucleotide gap region of toxic phosphorothioate (PS) gapmer ASOs can enhance therapeutic index and safety. In this manuscript, we determined the effe
Autor:
Claus Rentel, Hans Gaus, Kym Bradley, Nhuy Luu, Kimmy Kolkey, Bao Mai, Mark Madsen, Megan Pearce, Brandon Bock, Daniel Capaldi
Publikováno v:
Nucleic acid therapeutics. 32(3)
The relatively large molecular size, diastereoisomeric nature, and complex impurity profiles of therapeutic phosphorothioate oligonucleotides create significant analytical challenges for the quality control laboratory. To overcome the lack of selecti
Autor:
Michael Oestergaard, Minji Jo, Andres Berdeja, Punit P. Seth, Alfred E. Chappell, Thazha P. Prakash, Eric E. Swayze, Ruchi Gupta, Hans Gaus
Publikováno v:
Nucleic Acids Research
Conjugation of antisense oligonucleotide (ASO) with a variety of distinct lipophilic moieties like fatty acids and cholesterol increases ASO accumulation and activity in multiple tissues. While lipid conjugation increases tissue exposure in mice and
Publikováno v:
Drug Metabolism and Disposition. 47:1164-1173
Volanesorsen (previously known as ISIS 304801) is a 20-nucleotide partially 2'-O-(2-methoxyethyl) (2'-MOE)-modified antisense oligonucleotide (ASO) gapmer, which was recently approved in the European Union as a novel, first-in-class treatment in the
Autor:
Jinghua Yu, Alfred E. Chappell, Hans Gaus, Adam E. Mullick, Audrey Low, Richard G. Lee, Sue Murray, Steve T. Yeh, Eric E. Swayze, Punit P. Seth, Michael E. Østergaard, Thazha P. Prakash
Publikováno v:
Nucleic Acids Research
Enhancing the functional uptake of antisense oligonucleotide (ASO) in the muscle will be beneficial for developing ASO therapeutics targeting genes expressed in the muscle. We hypothesized that improving albumin binding will facilitate traversal of A
Autor:
Garth A. Kinberger, Michael Tanowitz, Linda Fradkin, Michael E. Østergaard, Alfred E. Chappell, Jinghua Yu, Richard G. Lee, Michaela Jackson, Sue Murray, Amy Dan, Frank Rigo, C. Frank Bennett, Patrick Anderson, Tae-Won Kim, Rick Carty, Adam E. Mullick, Hans Gaus, Eric E. Swayze, Audrey Low, Thazha P. Prakash, Punit P. Seth, Rachel Q Peralta
Publikováno v:
Nucleic Acids Research
We determined the effect of attaching palmitate, tocopherol or cholesterol to PS ASOs and their effects on plasma protein binding and on enhancing ASO potency in the muscle of rodents and monkeys. We found that cholesterol ASO conjugates showed 5-fol
Autor:
Ruchi Gupta, Eric E. Swayze, Alfred E. Chappell, Punit P. Seth, Hans Gaus, Michael E. Østergaard
Publikováno v:
Nucleic Acids Research
Interactions of chemically modified nucleic acid therapeutics with plasma proteins play an important role in facilitating distribution from the injection site to peripheral tissues by reducing renal clearance. Despite the importance of these interact