Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hans G. Genieser"'
Autor:
Andreas Rentsch, Manoj Kulkarni, Dorit Hoffmann, Marius Ueffing, Dragana Trifunović, François Paquet-Durand, Angelique van den Heuvel, Patricia Veiga-Crespo, Thomas Euler, Eleonora Vighi, Arie Reijerkerk, Torsten Strasser, Pieter J. Gaillard, Frank Schwede, Valeria Marigo, Evelina Bertolotti, Per Ekström, Tobias Peters, Ayse Sahaboglu, Hans G. Genieser
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Development of treatments for hereditary degeneration of the retina (RD) is hampered by the vast genetic heterogeneity of this group of diseases and by the delivery of the drug to an organ protected by the blood–retina barrier. Here, w
Autor:
Parisa Afshari, Hans G. Genieser, Colin A. Leech, Mandy Diskar, Daniela Bertinetti, Friedrich W. Herberg, Tamara Tsalkova, George G. Holz, Frank Schwede, Xiaodong Cheng, Oleg G. Chepurny
Publikováno v:
Molecular Endocrinology; Vol 27
GPR119 is a G protein-coupled receptor expressed on enteroendocrine L-cells that synthesize and secrete the incretin hormone glucagon-like peptide-1 (GLP-1). Although GPR119 agonists stimulate L-cell GLP-1 secretion, there is uncertainty concerning w
Autor:
Alan V. Smrcka, George G. Holz, Youming Lu, Elvira Dzhura, Michael W. Roe, Xin Xu, Hans G. Genieser, Colin A. Leech, Oleg G. Chepurny, Igor Dzhura, Frank Schwede
Publikováno v:
Islets. 3:121-128
Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells is potentiated by cAMP-elevating agents, such as the incretin hormone glucagon-like peptide-1 (GLP-1), and cAMP exerts its insulin secretagogue action by activating both protein kin
Autor:
Anna Klukovits, Friedrich W. Herberg, Kornelia Hampel, Dmitry Kashin, Kerstin Zühlke, Judit Verli, Andrey C. da Costa Goncalves, Mangesh Joshi, Hannelore Haase, Martin W. Bergmann, Bernd Reif, Marta Dr. Szaszak, Dorothea Lorenz, Robert S. Kass, Dermot M.F. Cooper, Hans G. Genieser, Ingo Morano, Solveig Grossmann, Sabine Friedl, Bastian Zimmermann, Marie C. Moutty, Peter Schmieder, Frank Christian, Hendrikje Göttert, George S. Baillie, Frank Götz, Carolyn Vargas, Walter Rosenthal, Miles D. Houslay, Jens Furkert, Jens Peter von Kries, Róbert Gáspár, Claudia Noack, Stephan Drewianka, Debbie Willoughby, Enno Klussmann
Publikováno v:
The Journal of Biological Chemistry
The journal of biological chemistry, 286: 9079-9096
The journal of biological chemistry, 286: 9079-9096
A-kinase anchoring proteins (AKAPs) tether protein kinase A (PKA) and other signaling proteins to defined intracellular sites, thereby establishing compartmentalized cAMP signaling. AKAP-PKA interactions play key roles in various cellular processes,
Autor:
Hans-G. Genieser, George G. Holz, Frank Schwede, Oleg G. Chepurny, Colin A. Leech, Igor Dzhura
Publikováno v:
Islets. 2:72-81
Clinical studies demonstrate that combined administration of sulfonylureas with exenatide can induce hypoglycemia in type 2 diabetic subjects. Whereas sulfonylureas inhibit ß-cell K(ATP) channels by binding to the sulfonylurea receptor-1 (SUR1), exe
Autor:
Colin A. Leech, Grant G. Kelley, Michael W. Roe, Elvira Dzhura, Parisa Afshari, Frank Schwede, Xiangquan Li, George G. Holz, Hans-G. Genieser, Oleg G. Chepurny, Igor Dzhura
Publikováno v:
Islets. 1:260-265
Epac2 is a cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF) that is proposed to mediate stimulatory actions of the second messenger cAMP on mouse islet insulin secretion. Here we have used methods of islet perifusion to demonstrate that t
Autor:
Frank Schwede, George G. Holz, Grant G. Kelley, Igor Dzhura, Michael J. Rindler, Elvira Dzhura, Xiangquan Li, Hans G. Genieser, Colin A. Leech, Oleg G. Chepurny
Publikováno v:
Journal of Biological Chemistry. 284:10728-10736
To ascertain the identities of cyclic nucleotide-binding proteins that mediate the insulin secretagogue action of cAMP, the possible contributions of the exchange protein directly activated by cAMP (Epac) and protein kinase A (PKA) were evaluated in
Autor:
Patrick E. MacDonald, Hans G. Genieser, Frank Schwede, Xiaodong Cheng, Yingmin Zhu, Fang C Mei, Jocelyn E. Manning Fox, Daniela Bertinetti, George G. Holz, Friedrich W. Herberg, Over Cabrera, Oleg G. Chepurny, Melanie Kaufholz, Colin A. Leech
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 29(7)
cAMP-elevating agents such as the incretin hormone glucagon-like peptide-1 potentiate glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. However, a debate has existed since the 1970s concerning whether or not cAMP signaling is esse
Autor:
Carine Maenhaut, Johannes L. Bos, Frank Schwede, Stein Ove Døskeland, Hans G. Genieser, Aurora Martinez, Sarah Dremier, Johan de Rooij, Anne Elisabeth Christensen, Frode Selheim, Khanh K. Dao
Publikováno v:
Journal of Biological Chemistry. 278:35394-35402
Little is known about the relative role of cAMP-dependent protein kinase (cAPK) and guanine exchange factor directly activated by cAMP (Epac) as mediators of cAMP action. We tested cAMP analogs for ability to selectively activate Epac1 or cAPK and di
Autor:
Michael B. Wheeler, Marie E. Monaco, Johannes L. Bos, George G. Holz, Hans-G. Genieser, Frank Schwede, Oleg G. Chepurny, Jamie W. Joseph, Guoxin Kang
Publikováno v:
Journal of Biological Chemistry. 278:8279-8285
The second messenger cAMP exerts powerful stimulatory effects on Ca(2+) signaling and insulin secretion in pancreatic beta-cells. Previous studies of beta-cells focused on protein kinase A (PKA) as a downstream effector of cAMP action. However, it is