Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Hans G. Folkesson"'
Autor:
Stephanie R. Kuzenko, Hans G. Folkesson, Mark A. Simmons, David A. Lipson, Michael A. Matthay
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 303:L259-L271
There is a significant unmet need for treatments of patients with acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). The primary mechanism that leads to resolution of alveolar and pulmonary edema is active vectorial Na+and Cl
Publikováno v:
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology. 294:1461-1471
Near the end of gestation, the direction of ion and fluid flow across the alveolar epithelium rapidly changes from secretion to absorption. Thus, the relative cell membrane location of epithelial Na channels (ENaCs) and cystic fibrosis transmembrane
Autor:
Michael B. Maron, Walter I. Horne, J. Gary Meszaros, Hans G. Folkesson, Vahagn Ohanyan, Charles F. Pilati, Shyny Koshy, Daniel J. Luther, Jon M. Walro, Tianbo Li
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 297:L487-L495
The alveolar epithelium plays a critical role in resolving pulmonary edema. We thus hypothesized that its function might be upregulated in rats with heart failure, a condition that severely challenges the lung's ability to maintain fluid balance. Hea
Autor:
David M. Guidot, Hans G. Folkesson, Jacob I. Sznajder, Michael A. Matthay, Jean-Francois Pittet, Lucky Jain
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 291:L301-L306
The acute respiratory distress syndrome (ARDS) is characterized by non-cardiogenic pulmonary edema and flooding of the alveolar air spaces with proteinaceous fluid. ARDS develops in response to inflammatory stresses including sepsis, trauma, and seve
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 291:L252-L256
We previously demonstrated that 48-h isoproterenol (Iso) infusion in rats impaired the ability of β-adrenoceptor (β-AR) agonists to increase alveolar liquid clearance (ALC). In this study, we determined whether this impairment persisted over longer
Autor:
Hans G. Folkesson, Tianbo Li
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L649-L660
We used siRNA against the alpha-ENaC (epithelial Na channel) subunit to investigate ENaC involvement in lung fluid absorption in rats by the impermeable tracer technique during baseline and after beta-adrenoceptor stimulation by terbutaline. Terbutal
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L769-L776
Some investigators have reported that endogenous β-adrenoceptor tone can provide protection against acute lung injury. Therefore, we tested the effects of β-adrenoceptor inhibition in mice with acute Escherichia coli pneumonia. Mice were pretreated
Autor:
Joseph A. Kitterman, Robert Ertsey, Cheryl J. Chapin, LaMonta L. Beard, Michael A. Matthay, Hans G. Folkesson
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L478-L484
We hypothesized that congenital diaphragmatic hernia (CDH) may decrease distal air space fluid absorption due to immaturity of alveolar epithelial cells from a loss of the normal epithelial Na+ transport, as assessed by amiloride and epithelial Na+ c
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 289:L1029-L1038
We tested the hypothesis that oxytocin-induced labor augmented IL-1beta-induced/-stimulated lung fluid absorption in preterm guinea pig fetuses. IL-1beta was administered subcutaneously daily to timed-pregnant guinea pigs for 3 days with and without
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 289:L349-L354
Isoproterenol (Iso) infusion for 48 h in rats decreases the ability of β-adrenoceptor (β-AR) agonists to increase alveolar liquid clearance (ALC). An impairment in protein kinase A (PKA) function appears to be critical in producing the desensitized