Výsledky vyhledávání - "Hans Emtenäs"

Using Spinchem Rotating Bed Reactor Technology for Immobilized Enzymatic Reactions: A Case Study

Autor: Subhash Pithani, Staffan Karlsson, Hans Emtenäs, Christopher T. Öberg

Publikováno v: Organic Process Research & Development. 23:1926-1931

The practically and financially viable use of immobilized enzymes in the production of pharmaceutical and bulk chemicals requires highly catalytically active enzymes and efficient mass transfer of ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d39b029e0dee31c729095b439fc98954
https://doi.org/10.1021/acs.oprd.9b00240

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Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease

Autor: Hans Ericsson, Igor L. Shamovsky, Carl Whatling, Malin Lemurell, Marianne Swanson, Eva-Lotte Lindstedt, Johan Broddefalk, Mats Någård, Anita Dellsén, Johan Ulander, Carl Amilon, Kenneth Granberg, Annika Westin Eriksson, Daniel Pettersen, Alleyn T. Plowright, Monica Sundqvist, Hans Emtenäs, Martin A. Hayes

Publikováno v: Journal of Medicinal Chemistry. 62:4312-4324

5-Lipoxygenase activating protein (FLAP) inhibitors attenuate 5-lipoxygenase pathway activity and reduce the production of proinflammatory and vasoactive leukotrienes. As such, they are hypothesized to have therapeutic benefit for the treatment of di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f5cbb07e77468dbbb61f1fcb001052
https://doi.org/10.1021/acs.jmedchem.8b02004

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A Practical Telescoped Three-Step Sequence for the Preparation of (1R,2R)-2-(4-Bromobenzoyl)cyclohexanecarboxylic Acid: A Key Building Block Used in One of Our Drug Development Projects

Autor: Peter R. Moore, Hans Emtenäs, Andrew Stark, Johan Broddefalk, Staffan Karlsson, Rolf Bergman, Christian Löfberg

Publikováno v: Organic Process Research & Development. 22:618-624

A large-scale, robust telescoped process involving acid chloride generation and Friedel–Crafts acylation followed by hydrolysis of an ester was developed for the manufacture of a homochiral disubstituted cyclohexane. Chromatography was avoided, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83e28764604100dd0596271543752ce9
https://doi.org/10.1021/acs.oprd.8b00066

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Development of a Safe Continuous Manufacturing Route to 2-(4-Isopropyl-1H-1,2,3-triazol-1-yl)acetic Acid

Autor: Hans Emtenäs, Paul M. Gillespie, Staffan Karlsson, Mubina Mohamed, Calum Cook, Kenny J. H. Fan

Publikováno v: Organic Process Research & Development. 21:1668-1674

Starting from sodium azide, methyl-bromoacetate, and 3-methylbut-1-yne, a safe and efficient three-step continuous process was developed to obtain 2-(4-isopropyl-1H-1,2,3-triazol-1-yl)acetic acid. Isolation of hazardous intermediates was avoided, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14167b9065deaf2d9f9005c92587ce9a
https://doi.org/10.1021/acs.oprd.7b00259

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Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease

Autor: Christian Löfberg, Marianne Swanson, ZhongQing Yuan, Johan Broddefalk, Annika Westin Eriksson, Susanne Winiwarter, Martin A. Hayes, Gabrielle Saarinen, Johan Meuller, Carl Whatling, Johan Ulander, Hans Emtenäs, Johan Cassel, Monica Sundqvist, Malin Lemurell, Luna Prieto Garcia, Staffan Karlsson

Publikováno v: Journal of medicinal chemistry. 62(9)

5-Lipoxygenase (5-LO)-activating protein (FLAP) inhibitors have proven to attenuate 5-LO pathway activity and leukotriene production in human clinical trials. However, previous clinical candidates have been discontinued and the link between FLAP inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff40a6805c4be041ac624c15aa826045
https://pubmed.ncbi.nlm.nih.gov/30929436

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Two Competing Mechanisms for the Copper-Free Sonogashira Cross-Coupling Reaction

Autor: Thomas Ljungdahl, Hans Emtenäs, Jerker Mårtensson, T.H Bennur, Andrea Dallas

Publikováno v: Organometallics. 27:2490-2498

The mechanism of the copper-free Sonogashira cross-coupling was investigated using a model reaction with differently para-substituted phenylacetylenes and 4-iodobenzotrifluoride as coupling partners and a Pd2(dba)3·CHCl3−AsPh3 catalyst system in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9706066a030ec9920b9f47e49ebb6b55
https://doi.org/10.1021/om800251s

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Discovery of AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP) for the treatment of inflammatory diseases

Autor: Susanne Winiwarter, Öjvind Davidsson, Alleyn T. Plowright, Anna Pettersen, Carl Whatling, Marie Rydén-Landergren, Johan Broddefalk, Margareta Herslöf, Jonas Gunnar Barlind, Daniel Hovdal, Kalle Sigfridsson, Tomas Drmota, Marianne Swanson, Hans Emtenäs, Antonio Llinas, Sara Moses, Johan Ulander, Anders Dahlén, Malin Lemurell

Publikováno v: Journal of medicinal chemistry. 58(2)

A drug discovery program in search of novel 5-lipoxygenase activating protein (FLAP) inhibitors focused on driving a reduction in lipophilicity with maintained or increased ligand lipophilic efficiency (LLE) compared to previously reported compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d45db613ea0bfe337b948d40f96b41
https://pubmed.ncbi.nlm.nih.gov/25478788

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Stereoselective synthesis of optically active bicyclic β-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteriaElectronic supplementary information (ESI) available: 13C NMR spectra of 7(a–g), 10–14, 16(a and d) and 17(a–b). See http://www.rsc.org/suppdata/ob/b2/b210551a

Autor: Hans Emtenäs, Marcus Carlsson, Scott J. Hultgren, Fredrik Almqvist, Jerome S. Pinkner

Publikováno v: Organic & Biomolecular Chemistry. 1:1308-1314

Optically active bicyclic β-lactams were synthesized, starting from 2-H-Δ2-thiazolines and Meldrum's acid derivatives. Several methods to accomplish an ester hydrolysis without damaging the β-lactam framework were investigated. A rapid CsOH saponi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffd14e8fe3776ecd696a8f5bd1fbbeb7
https://doi.org/10.1039/b210551a

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