Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Hans E. Krokan"'
Autor:
Lene Alsøe, Antonio Sarno, Sergio Carracedo, Diana Domanska, Felix Dingler, Lisa Lirussi, Tanima SenGupta, Nuriye Basdag Tekin, Laure Jobert, Ludmil B. Alexandrov, Anastasia Galashevskaya, Cristina Rada, Geir Kjetil Sandve, Torbjørn Rognes, Hans E. Krokan, Hilde Nilsen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional uracil DNA glycosylase
Externí odkaz:
https://doaj.org/article/200ff99a0e8a48df8df9562bc5e8eec8
Autor:
Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday
Publikováno v:
Nature Cancer
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc803a4ce48681e11987b33fd0a94af
https://doi.org/10.1038/s43018-022-00331-y
https://doi.org/10.1038/s43018-022-00331-y
Autor:
Daria Zdżalik, Cathrine B Vågbø, Finn Kirpekar, Erna Davydova, Alicja Puścian, Agnieszka M Maciejewska, Hans E Krokan, Arne Klungland, Barbara Tudek, Erwin van den Born, Pål Ø Falnes
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98729 (2014)
The ALKBH family of Fe(II) and 2-oxoglutarate dependent oxygenases comprises enzymes that display sequence homology to AlkB from E. coli, a DNA repair enzyme that uses an oxidative mechanism to dealkylate methyl and etheno adducts on the nucleobases.
Externí odkaz:
https://doaj.org/article/b2fee403fcd749dabb5b49aae995b66c
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 4212, p 4212 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 4212, p 4212 (2021)
DNA of all living cells undergoes continuous structural and chemical alterations resulting from fundamental cellular metabolic processes and reactivity of normal cellular metabolites and constituents. Examples include enzymatically oxidized bases, ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8c1e9094eddcc3d0f418d5f7b8b2fb
https://hdl.handle.net/11250/2788167
https://hdl.handle.net/11250/2788167
Autor:
B. Paizs, Edgar Hartsuiker, D. Chaplin, S. Gollins, L. Boeckemeier, Cathrine Broberg Vågbø, R. Beardmore, M. U. Gasasira, R. Kraehenbuehl, S. A. E. Lambert, Ellen G Vernon, A. Keszthelyi, Hans E. Krokan
Publikováno v:
Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2020, 6 (22), pp.eaaz4126. ⟨10.1126/sciadv.aaz4126⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2020, 6 (22), pp.eaaz4126. ⟨10.1126/sciadv.aaz4126⟩
Mre11 exonuclease activity removes gemcitabine from the nascent strand during DNA replication.
The Mre11 nuclease is involved in early responses to DNA damage, often mediated by its role in DNA end processing. MRE11 mutations and aberrant expres
The Mre11 nuclease is involved in early responses to DNA damage, often mediated by its role in DNA end processing. MRE11 mutations and aberrant expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b38365e0b9886b2161bbf5a4a44ede
https://hal.archives-ouvertes.fr/hal-03008931/document
https://hal.archives-ouvertes.fr/hal-03008931/document
U–G mismatches in DNA generally result from spontaneous cytosine deamination and are repaired by the base excision repair pathway to avoid mutations. However, as part of the adaptive immune response in B cells U–G mismatches are enzymatically gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3bfdd48989ed58f47c4d612849c2b24
https://doi.org/10.1039/9781839160769-00220
https://doi.org/10.1039/9781839160769-00220
Autor:
Nina-Beate Liabakk, Mirta M. L. Sousa, Per Arne Aas, Robin Mjelle, Marie Benner Lundbæk, Lars Hagen, Antonio Sarno, Hans E. Krokan, Bodil Kavli
Publikováno v:
Nucleic Acids Research
UNG is the major uracil-DNA glycosylase in mammalian cells and is involved in both error-free base excision repair of genomic uracil and mutagenic uracil-processing at the antibody genes. However, the regulation of UNG in these different processes is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb7489391aa2e45740531389b1dcc7e
https://hdl.handle.net/11250/2619516
https://hdl.handle.net/11250/2619516
Autor:
Tian-Peng Gu, Zhi-Mei Xu, Guo-Dong Chen, Guoliang Xu, Gui-Fang Xu, Bin-Bin Han, Magnar Bjørås, Jian-Huang Xue, Hans E. Krokan, Ya-Rui Du
Publikováno v:
Journal of Biological Chemistry. 291:731-738
In mammals, active DNA demethylation involves oxidation of 5-methylcytosine (5mC) into 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) by Tet dioxygenases and excision of these two oxidized bases by thymine DNA glycosylase (TDG). Although TDG is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e901c3b40da85e44d7e9208c072fa2b8
https://doi.org/10.1074/jbc.m115.693861
https://doi.org/10.1074/jbc.m115.693861
Publikováno v:
Genomic Uracil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eeb74beb09bbf61a975558f388538b2
https://doi.org/10.1142/9789813233508_0004
https://doi.org/10.1142/9789813233508_0004
Publikováno v:
Genomic Uracil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5ed0b1b9699848a08935a47eb197f40
https://doi.org/10.1142/9789813233508_0005
https://doi.org/10.1142/9789813233508_0005