Zobrazeno 1 - 10
of 977
pro vyhledávání: '"Hans Clevers"'
Autor:
Delilah Hendriks, Benedetta Artegiani, Thanasis Margaritis, Iris Zoutendijk, Susana Chuva de Sousa Lopes, Hans Clevers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mechanisms underlying human hepatocyte growth in development and regeneration are incompletely understood. In vitro, human fetal hepatocytes (FH) can be robustly grown as organoids, while adult primary human hepatocyte (PHH) organoids remain
Externí odkaz:
https://doaj.org/article/2af830c56ec0454f8a7fc1b29bfbca34
Autor:
Chaitra Rao, Danielle E Frodyma, Siddesh Southekal, Robert A Svoboda, Adrian R Black, Chittibabu Guda, Tomohiro Mizutani, Hans Clevers, Keith R Johnson, Kurt W Fisher, Robert E Lewis
Publikováno v:
eLife, Vol 13 (2024)
Externí odkaz:
https://doaj.org/article/706ac20d6e23427cb059a67f4a7e21d7
Autor:
Anna Pagliaro, Roxy Finger, Iris Zoutendijk, Saskia Bunschuh, Hans Clevers, Delilah Hendriks, Benedetta Artegiani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Pluripotent stem cell (PSC)-derived human brain organoids enable the study of human brain development in vitro. Typically, the fate of PSCs is guided into subsequent specification steps through static medium switches. In vivo, morphogen grad
Externí odkaz:
https://doaj.org/article/13e3eca99244404e9802541b35f6f911
Autor:
Kun Xiang, Ergang Wang, John Mantyh, Gabrielle Rupprecht, Marcos Negrete, Golshid Sanati, Carolyn Hsu, Peggy Randon, Anders Dohlman, Kai Kretzschmar, Shree Bose, Nicholas Giroux, Shengli Ding, Lihua Wang, Jorge Prado Balcazar, Qiang Huang, Pasupathi Sundaramoorthy, Rui Xi, Shannon Jones McCall, Zhaohui Wang, Chongming Jiang, Yubin Kang, Scott Kopetz, Gregory E. Crawford, Steven M. Lipkin, Xiao‐Fan Wang, Hans Clevers, David Hsu, Xiling Shen
Publikováno v:
Advanced Science, Vol 11, Iss 16, Pp n/a-n/a (2024)
Abstract Patient‐Derived Organoids (PDO) and Xenografts (PDX) are the current gold standards for patient‐derived models of cancer (PDMC). Nevertheless, how patient tumor cells evolve in these models and the impact on drug response remains unclear
Externí odkaz:
https://doaj.org/article/1bb7ddf32e6044c991fd4618eff54a98
Autor:
Sangho Lim, Gijs J. F. van Son, Ni Luh Wisma Eka Yanti, Amanda Andersson-Rolf, Sam Willemsen, Jeroen Korving, Hong-Gyun Lee, Harry Begthel, Hans Clevers
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114019- (2024)
Summary: Thymic epithelial cells (TECs) orchestrate T cell development by imposing positive and negative selection on thymocytes. Current studies on TEC biology are hampered by the absence of long-term ex vivo culture platforms, while the cells drivi
Externí odkaz:
https://doaj.org/article/4e939fc710f34c5baa9c4a569aa45c17
Autor:
Marco Calafiore, Ya-Yuan Fu, Paola Vinci, Viktor Arnhold, Winston Y. Chang, Suze A. Jansen, Anastasiya Egorova, Shuichiro Takashima, Jason Kuttiyara, Takahiro Ito, Jonathan Serody, Susumu Nakae, Heth Turnquist, Johan van Es, Hans Clevers, Caroline A. Lindemans, Bruce R. Blazar, Alan M. Hanash
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Intestinal stem cells (ISCs) maintain the epithelial lining of the intestines, but mechanisms regulating ISCs and their niche after damage remain poorly understood. Utilizing radiation injury to model intestinal pathology, we report here tha
Externí odkaz:
https://doaj.org/article/9b625ca7598346a7aef6d804ad1b9d63
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids
Autor:
Maarten H. Geurts, Shashank Gandhi, Matteo G. Boretto, Ninouk Akkerman, Lucca L. M. Derks, Gijs van Son, Martina Celotti, Sarina Harshuk-Shabso, Flavia Peci, Harry Begthel, Delilah Hendriks, Paul Schürmann, Amanda Andersson-Rolf, Susana M. Chuva de Sousa Lopes, Johan H. van Es, Ruben van Boxtel, Hans Clevers
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Optimization of CRISPR/Cas9-mediated genome engineering has resulted in base editors that hold promise for mutation repair and disease modeling. Here, we demonstrate the application of base editors for the generation of complex tumor models
Externí odkaz:
https://doaj.org/article/118466422c7b4a548268957a251cfb11
Autor:
Annie S. P. Yang, Devanjali Dutta, Kai Kretzschmar, Delilah Hendriks, Jens Puschhof, Huili Hu, Kim E. Boonekamp, Youri van Waardenburg, Susana M. Chuva de Sousa Lopes, Geert-Jan van Gemert, Johannes H. W. de Wilt, Teun Bousema, Hans Clevers, Robert W. Sauerwein
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Plasmodium falciparum (Pf) parasite development in liver represents the initial step of the life-cycle in the human host after a Pf-infected mosquito bite. While an attractive stage for life-cycle interruption, understanding of parasite-hepa
Externí odkaz:
https://doaj.org/article/5c88670c6cde4830afc419a55a86cad4
Autor:
Lin Lin, Hans Clevers
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 1, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/2afd4c9595034a7c9c03362043ac2e8c
Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease
Autor:
Fjodor A. Yousef Yengej, Carla Pou Casellas, Carola M.E. Ammerlaan, Charlotte J.A. Olde Hanhof, Emre Dilmen, Joep Beumer, Harry Begthel, Elise M.G. Meeder, Joost G. Hoenderop, Maarten B. Rookmaaker, Marianne C. Verhaar, Hans Clevers
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113614- (2024)
Summary: Organoid technology is rapidly gaining ground for studies on organ (patho)physiology. Tubuloids are long-term expanding organoids grown from adult kidney tissue or urine. The progenitor state of expanding tubuloids comes at the expense of di
Externí odkaz:
https://doaj.org/article/0b0f29d1d0104197b48e1e0d9de49d2d