Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Hans Christof Holst"'
Publikováno v:
Journal of Molecular Structure. 1031:254-262
Roflumilast is a selective phosphodiesterase type 4 inhibitor and is marketed under the brand names Daxas®, Daliresp® and Libertec®. A phase transition of the drug substance roflumilast was observed at 50 °C. The low temperature form, the high te
Autor:
Bernhard Kohl, Hans Christof Holst, Wilm Buhr, Georg Rainer, Peter Jan Zimmermann, Jörg Senn-Bilfinger
Publikováno v:
Synthesis. 2008:3065-3070
Selective directed ortho-metalation (DOM) of 2,3-dimethyl-8-(pivaloylamino)imidazo[1,2-a]pyridine in the 7-position was achieved with tert-butyllithium. Subsequent reaction of the lithiated derivative with tributylchlorostannane to the corresponding
Autor:
Vittoria Chiesa, Ulrike Nettekoven, Jacques Le Paih, Andreas Palmer, Antonio Zanotti-Gerosa, Hans Christof Holst
Publikováno v:
Tetrahedron: Asymmetry. 19:2102-2110
The asymmetric hydrogenation of complex heterocyclic ketones 1 in the presence of the novel catalyst RuCl2[(S)-Xyl-P-Phos][(S)-DAIPEN] and a base afforded the corresponding alcohols 2 in good enantiomeric purity. The outcome of the reaction depended
Publikováno v:
European Journal of Organic Chemistry. 2006:2609-2617
The 1,3,5-triazines 9–11 having OPV chains in the 2-, 4- and 6-position represent star-shaped compounds which exhibit strong push-pull effects. Their long-wavelength absorption S0 S1 is characterized by an intramolecular charge transfer (ICT) from
Publikováno v:
Tetrahedron. 60:6765-6775
Alkaline condensation reactions of 2,4,6-trimethyl-1,3,5-triazine ( 1 ) and substituted benzaldehydes ( 2a – n ) yield 2,4,6-tristyryl-1,3,5-triazines ( 3a – n ). A sufficient number and length of the alkoxy chains at the benzene rings provide li
Publikováno v:
Tetrahedron. 60:6881-6888
Star-shaped compounds, having a benzene ( 9a,b ) or a 1,3,5-triazine ( 11a,b ) core and stilbenoid arms were prepared. Hexyloxy chains, attached in the middle of the arms, provide nematic discotic phases ND, which are unusual for such systems. The po
Publikováno v:
European Journal of Organic Chemistry. 2003:4173-4180
The 1,3,5-triazine derivatives 1−4 having styryl or higher oligo(phenylenevinylene) chains in the 2-, 4-, and 6-positions represent star-shaped push-pull compounds. Alkoxy or dimethylamino groups on the peripheral benzene rings, which act as electr
Autor:
Herbert Meier, Hans Christof Holst
Publikováno v:
Advanced Synthesis & Catalysis. 345:1005-1011
Star-shaped compounds 2a–e with a central benzene ring and six p-substituted, (E)-configured styryl groups have been prepared by a sequence of three-fold Heck and three-fold Wittig–Horner reactions. Alkoxy chains (OC3H7, OC6H13, OC10H21, OC12H25)
Autor:
Hans Christof Holst, Ulrike Nettekoven, Vittoria Chiesa, Andreas Palmer, Jacques Le Paih, Antonio Zanotti-Gerosa
Publikováno v:
ChemInform. 40
The asymmetric hydrogenation of complex heterocyclic ketones 1 in the presence of the novel catalyst RuCl2[(S)-Xyl-P-Phos][(S)-DAIPEN] and a base afforded the corresponding alcohols 2 in good enantiomeric purity. The outcome of the reaction depended
Autor:
Wilm Buhr, Hans Christof Holst, Wolfgang Alexander Simon, Andreas Palmer, Burkhard Grobbel, Christof Brehm, Martin Feth, Peter Jan Zimmermann
Publikováno v:
Bioorganicmedicinal chemistry. 15(24)
A series of novel tetrahydroimidazo[2,1- a ]isoquinolines was prepared based on a hetero Diels–Alder reaction between an enamine and 1,2,4-triazine as key step. A structure–activity relationship was established focussing on the influence of the s