Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hans Certa"'
Autor:
Dorothea Eigler, Carl Haux, Reinhard Kreiling, Cynthia Graham, Roger Emter, Annette Mehling, Christine Garcia, Stuart Cagen, Andreas Natsch, Nicholas Ball, Hans Certa, Frank Faulhammer, Juan-Carlos Carrillo, Susanne N. Kolle
Publikováno v:
Regulatory Toxicology and Pharmacology. 60:389-400
An integral part of hazard and safety assessments is the estimation of a chemical’s potential to cause skin sensitization. Currently, only animal tests (OECD 406 and 429) are accepted in a regulatory context. Nonanimal test methods are being develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d56cc2e1636e66e9c882e7b1b7cfab
https://doi.org/10.1016/j.yrtph.2011.05.007
https://doi.org/10.1016/j.yrtph.2011.05.007
Autor:
Stuart Cagen, Nicholas Ball, Christine Garcia, Hans Certa, Reinhard Kreiling, Carl Haux, Annette Mehling, Juan-Carlos Carrillo, Cynthia Graham, Harald L. Esch, Dorothea Eigler
Publikováno v:
Regulatory Toxicology and Pharmacology. 58:301-307
The Local Lymph Node Assay (LLNA) is the preferred test for the identification of skin-sensitizing potentials of chemicals in Europe and is also the first choice method within REACH. In the formal validation, only a very few surfactant chemicals were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8fbdda6e5c934eec6c2e3a45f1c6d4
https://doi.org/10.1016/j.yrtph.2010.06.016
https://doi.org/10.1016/j.yrtph.2010.06.016
Autor:
Scott D. Dyer, Peter R. Fisk, Scott E. Belanger, Richard Sedlak, Gauke Veenstra, Catherine Webb, David Penney, Kathleen Stanton, Yutaka Kasai, Andreas Willing, Hans Certa, Allen M. Nielsen, Hans Sanderson
Publikováno v:
Ecotoxicology and Environmental Safety. 72:1016-1030
Representative chemicals from the long chain alcohols category have been extensively tested to define their toxicological hazard properties. These chemicals show low acute and repeat dose toxicity with high-dose effects (if any) related to minimal li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e48e2e0c5dc24f0138ab8544e19691f
https://doi.org/10.1016/j.ecoenv.2008.07.012
https://doi.org/10.1016/j.ecoenv.2008.07.012
Publikováno v:
Archives of Toxicology. 72:807-810
The present study describes the kinetics of tetrahydronaphthalene in male and female rats (five animals per dose per sex) at three dose levels (15, 50, and 150 mg/kg daily). Plasma concentration measurements were performed in the course of a subacute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a8d2784cc9ac3622867ebc8c99bab0
https://doi.org/10.1007/s002040050577
https://doi.org/10.1007/s002040050577
Autor:
Hans-Jürgen Wiegand, Norbert Fedtke, Stephen W. Dean, Jean-François Régnier, Richard Marshall, Rolf Ebert, Hans Certa
Publikováno v:
Mutation Research/Genetic Toxicology. 322:33-44
In a recent 2-year inhalation study with F344 rats and B6C3F1 mice conducted as part of the U.S. National Toxicology Program (NTP, 1989), chloroethane (ECl) at an exposure concentration of 15,000 ppm induced a high incidence of endometrial uterine ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28205e39b9dfaefe2c3b44ce351a84fa
https://doi.org/10.1016/0165-1218(94)90030-2
https://doi.org/10.1016/0165-1218(94)90030-2
Autor:
Christine Garcia, Stuart Cagen, Nicholas Ball, Carl Haux, Annette Mehling, Dorothea Eigler, Cynthia Graham, Reinhard Kreiling, Juan-Carlos Carrillo, Harald L. Esch, Hans Certa, David A. Basketter
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 55(1)
The local lymph node assay (LLNA) is the assay of choice in European regulatory toxicology. As with other toxicology/sensitisation assays, it has a potential for false results, the anionic surfactant sodium lauryl sulphate (SLS) representing a classi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4099c7396efd1def6c89354ea60c17
https://pubmed.ncbi.nlm.nih.gov/19523501
https://pubmed.ncbi.nlm.nih.gov/19523501
Autor:
Richard Sedlak, Daniel M. Woltering, Lela Jovanovich, Hans Certa, Caritas Tibazarwa, Kathleen Stanton, William Greggs, Donna Hillebold
Publikováno v:
Integrated environmental assessment and management. 6(1)
An environmental assessment of hydrotropes was conducted under the Organisation for Economic Co-operation and Development (OECD) Screening Information Data Sets (SIDS) for High Production Volume (HPV) Program via the Global International Council of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d99da552e80808771887794a6125bd2
https://pubmed.ncbi.nlm.nih.gov/19558203
https://pubmed.ncbi.nlm.nih.gov/19558203
Publikováno v:
Archives of toxicology. 73(4-5)
Female DA/Han rats were administered p-tert-octylphenol [OP; p-(1,1,3,3-tetramethylbutyl)-phenol], either intravenously (5 mg/kg body wt.) or orally by gavage (50 or 200 mg/kg body wt.). After i.v. administration the blood concentration-time curve of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a7099899f0be4c98f3bd50ad84aa55
https://pubmed.ncbi.nlm.nih.gov/10463386
https://pubmed.ncbi.nlm.nih.gov/10463386
Autor:
Dorothea Eigler, Gauke Veenstra, Carl Haux, Hans Certa, Reinhard Kreiling, Harald L. Esch, Annette Mehling, Nicholas Ball
Publikováno v:
Toxicology Letters. 172:S8-S9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4cca8a11a78eda3ae147b659065650e
https://doi.org/10.1016/j.toxlet.2007.05.043
https://doi.org/10.1016/j.toxlet.2007.05.043
Autor:
Christine Garcia, Juan-Carlos Carrillo, Dorothea Eigler, Cynthia Graham, Ball Nicholas, Reinhard Kreiling, Harald L. Esch, Cagen Stuart, Hans Certa, Annette Mehling, Carl Haux
Publikováno v:
Toxicology Letters. 189:S269
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f13f75c972354172586ab0e0cdd69f13
https://doi.org/10.1016/j.toxlet.2009.06.836
https://doi.org/10.1016/j.toxlet.2009.06.836