Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hans C.A. Raaijmakers"'
Autor:
Marcel van Duin, Rita Azevedo, Hans Hamersma, Diep Vu-Pham, Arthur Oubrie, Scott J. Lusher, Rolien Bosch, Bert Kazemier, Hans C.A. Raaijmakers, Jacob de Vlieg, Koen J. Dechering, Ross McGuire
Publikováno v:
Journal of Biological Chemistry, 287, 20333-20343
Journal of Biological Chemistry, 287, 24, pp. 20333-20343
Journal of Biological Chemistry, 287, 24, pp. 20333-20343
Contains fulltext : 103894.pdf (Publisher’s version ) (Open Access) We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed profile PR modulators whose functional activity results from two differing molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5603237fee702c88c44068b45f204787
https://doi.org/10.1074/jbc.m111.308403
https://doi.org/10.1074/jbc.m111.308403
Autor:
Joseph A. Kozlowski, Hao Wu, Chundao Yang, Jie Zhang-Hoover, Thierry O. Fischmann, Jeremy Presland, Sobhana Babu Boga, Allard Kaptein, Philip E. Brandish, Ying-Duo Gao, Kevin M. Maloney, Arto D. Krikorian, Shilan Liu, My Sam Mansueto, Abdul-Basit Alhassan, Henry M. Vaccaro, Diep Vu-Pham, Erica Leccese, Ronald M. Kim, Alexandra Hicks, Alan B. Cooper, Charles G. Garlisi, Jian Liu, Nathan Bays, Hans C.A. Raaijmakers, Jos de Man, Peter Stivers, Wang James J-S, Deodial Guiadeen, Xiaolei Gao, Viktor Hornak, Younong Yu, Ian Knemeyer, Zangwei Xu
Publikováno v:
ACS medicinal chemistry letters. 7(2)
Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B cell inhibition and for the treatment of B cell related diseases. We report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef21521484b31fc31f3730ab2c22387
https://pubmed.ncbi.nlm.nih.gov/26985298
https://pubmed.ncbi.nlm.nih.gov/26985298
Autor:
Ross McGuire, Rolien Bosch, Jacob de Vlieg, Niall M. Hamilton, Olaf Nimz, Koen J. Dechering, Angus R. Brown, Scott J. Lusher, Tsang Wai Lam, Arthur Oubrie, Diep Vu-Pham, Hans C.A. Raaijmakers
Publikováno v:
Journal of Biological Chemistry, 286, 35079-35086
Journal of Biological Chemistry, 286, 40, pp. 35079-35086
Journal of Biological Chemistry, 286, 40, pp. 35079-35086
The progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. We describe here two new pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe67a191b82ca4f7414febeccbc79a8
https://doi.org/10.1074/jbc.m111.273029
https://doi.org/10.1074/jbc.m111.273029
Autor:
Christian Grütter, Daniel Rauh, Tjeerd Barf, Willem A. L. van Otterlo, Jeffrey R. Simard, Matthias Rabiller, Vijaykumar Pawar, Hans C.A. Raaijmakers, Haridas B. Rode, Sabine Klüter
Publikováno v:
ChemBioChem. 11:2557-2566
Targeting protein kinases in cancer therapy with irreversible small-molecule inhibitors is moving to the forefront of kinase-inhibitor research and is thought to be an effective means of overcoming mutation-associated drug resistance in epidermal gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065fb40f609e6447ee5aa5335ffe5f0d
https://doi.org/10.1002/cbic.201000352
https://doi.org/10.1002/cbic.201000352
Autor:
Arthur Oubrie, Hans C.A. Raaijmakers, van M Zeeland, Rita Azevedo, B Kazemier, de J Jacob Vlieg
Publikováno v:
Acta Crystallographica Section D-Biological Crystallography, 68, Pt 8, pp. 1041-1050
Acta Crystallographica Section D-Biological Crystallography, 68, 1041-1050
Acta Crystallographica Section D-Biological Crystallography, 68, 1041-1050
Contains fulltext : 103893.pdf (Publisher’s version ) (Open Access) The p38alpha mitogen-activated protein kinase regulates the synthesis of pro-inflammatory cytokines in response to stimulation by a diverse set of stress signals. Various different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4374f62c3825cc885aa0d548808ecd
https://doi.org/10.1107/S090744491201997X
https://doi.org/10.1107/S090744491201997X
Autor:
Daniel Rauh, Matthias Rabiller, Hans C.A. Raaijmakers, Sabine Klüter, Willem A. L. van Otterlo, Christian Grütter, Vijaykumar Pawar, Jeffrey R. Simard, Tjeerd Barf, Haridas B. Rode
Publikováno v:
ChemBioChem. 11:2474-2474
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72a291e673cf50a11024a4df774196f9
https://doi.org/10.1002/cbic.201090088
https://doi.org/10.1002/cbic.201090088