Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hans B. Ketelslegers"'
Publikováno v:
Critical Reviews in Toxicology. :1-24
Are dose-response relationships for benzene and health effects such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) supra-linear, with disproportionately high risks at low concentrations, e.g. below 1 ppm? To investigate this hypot
Autor:
Peter J. Boogaard, Jochen Buschmann, Wolfgang Koch, Hans B. Ketelslegers, Rainer Fuhst, Katharina Schwarz, Christine McAlinden, Mathieu Vaissiere, Anna Steneholm, Katharina Blümlein, Dirk Schaudien, Lize Deferme
Publikováno v:
Reproductive Toxicology. 99:15-26
The prenatal developmental toxicity of bitumen fume was tested by nose-only inhalation in the rat. The fumes for exposure were collected from the headspace of a storage tank filled with a bitumen corresponding in composition to an anticipated worst-c
Autor:
John S, House, Fabian A, Grimm, William D, Klaren, Abigail, Dalzell, Srikeerthana, Kuchi, Shu-Dong, Zhang, Klaus, Lenz, Peter J, Boogaard, Hans B, Ketelslegers, Timothy W, Gant, Ivan, Rusyn, Fred A, Wright
Publikováno v:
ALTEX.
The application of in vitro biological assays as new approach methodologies (NAMs) to support grouping of UVCB (unknown or variable composition, complex reaction products, and biological materials) substances has recently been demonstrated. In additi
Autor:
Bert Spenkelink, Hans B. Ketelslegers, Peter J. Boogaard, Lenny Kamelia, Ivonne M.C.M. Rietjens, Laura H.J. de Haan, Ben Bruyneel
Publikováno v:
Journal of Applied Toxicology 40 (2020) 3
Journal of Applied Toxicology
Journal of Applied Toxicology, 40(3), 330-341
Journal of Applied Toxicology
Journal of Applied Toxicology, 40(3), 330-341
In vitro assays presently used for prenatal developmental toxicity (PDT) testing only assess the embryotoxic potential of parent substances and not that of potentially embryotoxic metabolites. Here we combined a biotransformation system, using hamste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b9b0bdb1fd7b8d855e2d5c23f013d1
https://research.wur.nl/en/publications/the-role-of-metabolism-in-the-developmental-toxicity-of-polycycli
https://research.wur.nl/en/publications/the-role-of-metabolism-in-the-developmental-toxicity-of-polycycli
Autor:
Peter J. Boogaard, Timothy W. Gant, Abigail Dalzell, John S. House, Fabian A. Grimm, Srikeerthana Kuchi, William D. Klaren, Fred A. Wright, Klaus Lenz, Hans B. Ketelslegers, Ivan Rusyn, Shu-Dong Zhang
Publikováno v:
ALTEX
One of the most challenging areas in regulatory science is assessment of the substances known as UVCB (Unknown or Variable composition, Complex reaction products and Biological materials). Because the inherent complexity and variability of UVCBs pres
Autor:
Peter J. Boogaard, A. Robert Schnatter, Louis Anthony Cox, Marcy I. Banton, Hans B. Ketelslegers
Publikováno v:
Chemico-Biological Interactions. 278:242-255
Two apparently contradictory findings in the literature on low-dose human metabolism of benzene are as follows. First, metabolism is approximately linear at low concentrations, e.g., below 10 ppm. This is consistent with decades of quantitative model
Autor:
Weihsueh A. Chiu, Hans B. Ketelslegers, Peter J. Boogaard, Yu-Syuan Luo, Yasuhiro Iwata, Tim Roy, Fabian A. Grimm, Ivan Rusyn, William K. Russell
Publikováno v:
Environmental Science & Technology. 51:7197-7207
Substances of Unknown or Variable composition, Complex reaction products, and Biological materials (UVCBs), including many refined petroleum products, present a major challenge in regulatory submissions under the EU Registration, Evaluation, Authoris
Autor:
Laura H.J. de Haan, Hans B. Ketelslegers, Peter J. Boogaard, Lenny Kamelia, Ivonne M.C.M. Rietjens
Publikováno v:
Toxicology Letters 315 (2019)
Toxicology Letters, 315, 64-76
Toxicology Letters, 315, 64-76
To test the hypothesis that 3–7 ring polycyclic aromatic hydrocarbons (PAHs) are responsible for the prenatal developmental toxicity (PDT) as observed with some petroleum substances (PS), the present study evaluates the PDT potency of DMSO-extracts
Autor:
Peter J. Boogaard, David M. Reif, Hans B. Ketelslegers, David Gerhold, Fabian A. Grimm, Bruce Seligmann, Peter J. Shepard, Fred A. Wright, Grace A. Chappell, Yasuhiro Iwata, Arlean Rohde, John C. Braisted, Joanne M. Yeakley, Oksana Sirenko, Ivan Rusyn, Tim Roy
Publikováno v:
Green Chemistry. 18:4407-4419
Comparative assessment of potential human health impacts is a critical step in evaluating both chemical alternatives and existing products on the market. Most alternatives assessments are conducted on a chemical-by-chemical basis and it is seldom ack
Autor:
Hans B. Ketelslegers, S. Brugman, L.H.J. de Haan, Peter J. Boogaard, Ivonne M.C.M. Rietjens, Lenny Kamelia
Publikováno v:
Altex, 36(2), 245-260
Altex 36 (2018) 2
Altex 36 (2018) 2
The present study evaluates the applicability of the zebrafish embryotoxicity test (ZET) to assess prenatal developmental toxicity (PDT) potency of the DMSO-extracts of 9 petroleum substances (PS), with variable polycyclic aromatic hydrocarbon (PAH)