Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Hans B, Liu"'
Autor:
Fan Tang, Tao Dong, Chengqian Zhou, Leon Deng, Hans B. Liu, Wenshen Wang, Guanshu Liu, Mingyao Ying, Pan P. Li
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Background Extracellular vesicles (EVs) are cell-secreted membrane vesicles that have become a promising, natural nanoparticle system for delivering either naturally carried or exogenously loaded therapeutic molecules. Among reported cell so
Externí odkaz:
https://doaj.org/article/86c67687ec7a4e2d956c682d7bb5d9ce
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103441- (2024)
Spinocerebellar ataxia type 12 (SCA12) is caused by a CAG expansion mutation in PPP2R2B, a gene encoding brain-specific regulatory units of protein phosphatase 2A (PP2A); while normal alleles carry 4 to 31 triplets, the disease alleles carry 43 to 78
Externí odkaz:
https://doaj.org/article/08c786ae18024f3eaddac5fa6da5e56f
Autor:
Kaushal Asrani, Juhyung Woo, Adrianna A. Mendes, Ethan Schaffer, Thiago Vidotto, Clarence Rachel Villanueva, Kewen Feng, Lia Oliveira, Sanjana Murali, Hans B. Liu, Daniela C. Salles, Brandon Lam, Pedram Argani, Tamara L. Lotan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The MiT/TFE transcription factors are phosphorylated and inactivated by mTORC1. Here, authors demonstrate that TFEB is paradoxically hypophosphorylated and activated in cells with TSC2 loss due to impaired lysosomal recruitment of the FLCN:FNIP2 comp
Externí odkaz:
https://doaj.org/article/4623887c9128432597fc0c714da4e302
Publikováno v:
eLife, Vol 12 (2023)
Iron-sulfur clusters (FeS) are ancient and ubiquitous protein cofactors that play fundamental roles in many aspects of cell biology. These cofactors cannot be scavenged or trafficked within a cell and thus must be synthesized in any subcellular compa
Externí odkaz:
https://doaj.org/article/ce09e69f61c844f6bb4baf8d10bceb19
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Ferredoxin (Fd) and ferredoxin-NADP+ reductase (FNR) form a redox system that is hypothesized to play a central role in the maintenance and function of the apicoplast organelle of malaria parasites. The Fd/FNR system provides reducing power
Externí odkaz:
https://doaj.org/article/af95598f7f9641da8698830ee3641551
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
ABSTRACT One of the most powerful approaches to understanding gene function involves turning genes on and off at will and measuring the impact at the cellular or organismal level. This particularly applies to the cohort of essential genes where tradi
Externí odkaz:
https://doaj.org/article/77e22b65157a4d319741ced515098f06
Autor:
Russell P Swift, Krithika Rajaram, Cyrianne Keutcha, Hans B Liu, Bobby Kwan, Amanda Dziedzic, Anne E Jedlicka, Sean T Prigge
Publikováno v:
eLife, Vol 9 (2020)
The apicoplast of Plasmodium falciparum parasites is believed to rely on the import of three-carbon phosphate compounds for use in organelle anabolic pathways, in addition to the generation of energy and reducing power within the organelle. We genera
Externí odkaz:
https://doaj.org/article/8ba230931280402babefe27f33d8cdda
Autor:
Russell P Swift, Krithika Rajaram, Hans B Liu, Amanda Dziedzic, Anne E Jedlicka, Aleah D Roberts, Krista A Matthews, Hugo Jhun, Namandje N Bumpus, Shivendra G Tewari, Anders Wallqvist, Sean T Prigge
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008316 (2020)
Malaria parasites rely on a plastid organelle for survival during the blood stages of infection. However, the entire organelle is dispensable as long as the isoprenoid precursor, isopentenyl pyrophosphate (IPP), is supplemented in the culture medium.
Externí odkaz:
https://doaj.org/article/ae89fcfe1c5546e892dac3f249d96b6d
Publikováno v:
eLife. 12
Iron-sulfur clusters (FeS) are ancient and ubiquitous protein cofactors that play fundamental roles in many aspects of cell biology. These cofactors cannot be scavenged or trafficked within a cell and thus must be synthesized in any subcellular compa