Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hans Allgeier"'
Autor:
Stephan Urwyler, Samuel Hintermann, Daniel Hoyer, Thomas Moenius, Steven Whitebread, Michel Lemaire, Ivo Vranesic, Hans Allgeier, Armin Brülisauer, Yves Auberson, Fabrizio Gasparini
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:903-914
[(11)C]ABP688 (2) has recently been demonstrated to be a useful PET tracer for in vivo imaging of the metabotropic glutamate receptors type 5 (mGluR5) in rodents. We describe here the identification and preclinical profiling of ABP688 and its tritiat
Autor:
Hans Allgeier, Yves Auberson, Serge Bischoff, Robert Moretti, Markus Schmutz, Kurt Lingenhoehl
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1099-1102
NMDA antagonists derived from 5-phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione (3a) are potent anticonvulsant agents, and display strong protective effects in the electroshock-induced convulsion assay in mice. Their preference for the human NMDAR 1
Autor:
Hanns Möhler, Roland Heckendorn, Christof Angst, M. Honer, Hans Allgeier, Mario F. Pozza, Dietmar Benke
Publikováno v:
Neuropharmacology. 38:233-242
Activation of NMDA receptors requires the presence of glycine as a coagonist which binds to a site that is allosterically linked to the glutamate binding site. To identify the protein constituents of the glycine binding site in situ the photoaffinity
Autor:
Hannah Monyer, Hanns Möhler, Bodo Laube, Peter H. Seeburg, Hans Allgeier, Jochen Kuhse, Heinrich Betz, Roland Heckendorn, Christof Angst, Michael Honer, Dietmar Benke
Publikováno v:
The Journal of Biological Chemistry
The binding site for the co-agonist glycine on N-methyl-D-aspartate (NMDA) receptors has been mapped to the NR1 subunit whereas binding of the principal agonist glutamate is mediated by the NR2 subunits. Using the novel glycine site antagonist and ph
Publikováno v:
ResearcherID
Autor:
David Orain, Philipp Floersheim, Sandrine Desrayaud, Silvio Ofner, Manuel Koller, Stephan Urwyler, David Carcache, Nicolas Soldermann, Hans Allgeier, Henri Mattes, Joerg Kallen, Kurt Lingenhoehl, Wolfgang Froestl, Vittorio Rasetti, Joachim Nozulak
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(2)
A new set of quinazolinedione sulfonamide derivatives as competitive AMPA receptor antagonist with improved properties compared to 1 is disclosed. By modulating physico-chemical properties, compound 29 was identified with a low ED 50 of 5.5 mg/kg in
Publikováno v:
Journal of Medicinal Chemistry. 36:3721-3726
Four omega-benzoylated (E)-2,10-diamino-4-(phosphonomethyl)dec-3-enoic acids have been synthesized and tested in vitro for binding affinity to the glutamate recognition site of the NMDA (N-methyl-D-aspartate) receptor. The omega-4-azidosalicylamide d
Autor:
Roland Heckendorn, D. Laurie, Dietmar Benke, Peter H. Seeburg, Thomas M. Marti, C Angst, S Mertens, H. Möhler, Pozza Mf, Hans Allgeier
Publikováno v:
Proceedings of the National Academy of Sciences. 90:8434-8438
Activation of N-methyl-D-aspartate (NMDA) receptors is essential for synaptic plasticity in the central nervous system and contributes to neuronal death under various pathological conditions. Although several subunits have been cloned, the structure
Autor:
Siem Jacob Veenstra, Pierre Acklin, Hans Allgeier, Michel Biollaz, Silvio Ofner, Serge Bischoff, Yves Auberson
Publikováno v:
ChemInform. 29
Autor:
Hans Allgeier, Serge Bischoff, Pierre Acklin, Markus Schmutz, Silvio Ofner, Dirk Sauer, Yves Auberson
Publikováno v:
ChemInform. 29