An in vitro model system based on calcium- and phosphate ion-induced hMSC spheroid mineralization

Autor: Steven Vermeulen, Kèvin Knoops, Hans Duimel, Maryam Parvizifard, Denis van Beurden, Carmen López-Iglesias, Stefan Giselbrecht, Roman Truckenmüller, Pamela Habibović, Zeinab Tahmasebi Birgani

Publikováno v: Materials Today Bio, Vol 23, Iss , Pp 100844- (2023)

A challenge in regenerative medicine is creating the three-dimensional organic and inorganic in vitro microenvironment of bone, which would allow the study of musculoskeletal disorders and the generation of building blocks for bone regeneration. This

Externí odkaz: https://doaj.org/article/b063838695a64f8a9f2b2869700de350

Secretion of pro‐angiogenic extracellular vesicles during hypoxia is dependent on the autophagy‐related protein GABARAPL1

Autor: Tom G. Keulers, Sten F. Libregts, Joel E.J. Beaumont, Kim G. Savelkouls, Johan Bussink, Hans Duimel, Ludwig Dubois, Marijke I. Zonneveld, Carmen López‐Iglesias, Karel Bezstarosti, Jeroen A. Demmers, Marc Vooijs, Marca Wauben, Kasper M.A. Rouschop

Publikováno v: Journal of Extracellular Vesicles, Vol 10, Iss 14, Pp n/a-n/a (2021)

Abstract Tumour hypoxia is a hallmark of solid tumours and contributes to tumour progression, metastasis development and therapy resistance. In response to hypoxia, tumour cells secrete pro‐angiogenic factors to induce blood vessel formation and re

Externí odkaz: https://doaj.org/article/af6b9ede953b475aa1ad89c65bcf4ab4

Desymmetrization via Activated Esters Enables Rapid Synthesis of Multifunctional Benzene-1,3,5-tricarboxamides and Creation of Supramolecular Hydrogelators

Autor: Shahzad Hafeez, Huey Wen Ooi, Dennis Suylen, Hans Duimel, Tilman M. Hackeng, Clemens van Blitterswijk, Matthew B. Baker

Publikováno v: Journal of the American Chemical Society, 144(9), 4057-4070. American Chemical Society

Supramolecular materials based on the self-assembly of benzene-1,3,5-tricarboxamide (BTA) offer an approach to mimic fibrous self-assembled proteins found in numerous natural systems. Yet, synthetic methods to rapidly build complexity, scalability, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a77e46dc1ca88de9e133e3eb8c0f171
https://doi.org/10.1021/jacs.1c12685

Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer

Autor: Roman Eickhoff, Long Jiao, Antje Egners, Lara R. Heij, Ulf P. Neumann, Hans Duimel, Johanna Roth, Sandra Jumpertz, Carmen López-Iglesias, Maximilian Schmeding, David Meierhofer, Andreas Kroh, Pilar Caro, Thorsten Cramer, Merve Erdem

Publikováno v: Journal of Pathology, 255(3), 270-284. Wiley
The Journal of Pathology : an Official Journal of the Pathological Society of Great Britain and Ireland

Activation of the mechanistic target of rapamycin (mTOR) pathway is frequently found in cancer, but mTOR inhibitors have thus far failed to demonstrate significant antiproliferative efficacy in the majority of cancer types. Besides cancer cell-intrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0def7e75aa13b2655d3b67adbef44fff
https://pubmed.ncbi.nlm.nih.gov/34309874

Electron microscopic observations in perfusion-fixed human non-alcoholic fatty liver disease biopsies

Autor: Eddie Wisse, Hans Duimel, Robert G. Riedl, Daisy Jonkers, Ger H. Koek, Ad A.M. Masclee, Joanne Verheij, Toon. J. I. De Munck, Pauline Verhaegh, Jan Greve

Publikováno v: Pathology, 53(2), 220-228. LIPPINCOTT WILLIAMS & WILKINS
Pathology, 53(2), 220-228. Lippincott Williams and Wilkins

Non-alcoholic fatty liver disease (NAFLD) is a widespread liver disease in Western society, but its multifactorial pathogenesis is not yet fully understood. Ultrastructural analysis of liver sinusoidal endothelial cells (LSECs) in animal models and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8c506652fab302bf0eb858f0a53b26
https://cris.maastrichtuniversity.nl/en/publications/fb0af876-b032-444a-b861-721d4173016d