Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Hans‐Hartwig Otto"'
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 10, Pp o2951-o2952 (2012)
The title nitrothiophene compound, C13H9N3O6S2, crystallizes with two independent molecules in the asymmetric unit; the molecular structure of each is stabilized by an intramolecular N—H...O hydrogen bond. The two molecules adopt flattened but slig
Externí odkaz:
https://doaj.org/article/b664da62d01246c49971fa5d91af49dd
Autor:
Martin Müller, Hans-Hartwig Otto
Publikováno v:
Archiv der Pharmazie. 324:773-778
Aldol reactions between N-silylated or 2,3-disubstituted β-sultams and ketones or aldehydes result in the C-4 aldol derivatives 2 and 6. Desilylation of 2 with TBAF yields the N-unsubstituted compounds 3. Mixtures of diastereomers obtained from reac
Publikováno v:
Archiv der Pharmazie. 324:563-572
The (E)-1-hetaryl-2-propen-1-ones 3 and 4 are prepared by condensation of 2-acetylthiophenes (1a,1c,1d) or 2-acetylfuran (1b) with aldehydes. The Michael adducts 5/6 are obtained from 3/4 by reaction with malononitrile/LDA in THF at −78°C, or in D
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 139:835-846
Different modifications of the imine – acyl chloride reaction were used for the synthesis of 3-mono- and 3,3-dihalogenated 1,4-diaryl substituted β-lactams. Furthermore, these β-lactams were modified by halogen substitution either at the aryl at
Autor:
Susanne Gürtler, Renate Grünert, Gerd Neudert, Hans-Hartwig Otto, Patrick J. Bednarski, Sabine Ruf
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 139:847-857
A number of 1,4-diaryl-3-methylene substituted β-lactams, the addition products obtained from their reactions with N-, S-, and C-nucleophiles, and diverse related compounds were prepared, and a selection of 43 compounds was screened in preliminary t
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 138:627-634
4-Phenylazetidine-2-one was transformed into 4-phenylazetidine-1-alkanoic acids, which were reacted in the presence of diphenylphosphoroazidate with amino acid esters and dipeptide esters yielding β-lactam peptides with different spacers between the
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 137:1441-1451
Reactions of cyanomethanesulfonamides with aromatic aldehydes in the presence of AcOH and piperidine produced the addition products, the 1-cyano-2-arylethenesulfonamides, whereas reactions with benzonitrile yielded the 2-amino-1-cyano-2-phenylethenes
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 137:1321-1347
Cyanomethanesulfonyl chloride was reacted with amines yielding cyanomethanesulfonamides which could be transformed into alkoxymethylidene and aminomethylidene derivatives. The reaction of alkoxymethylidene derivatives with phenylhydrazine resulted in
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 137:83-103
The cycloaddition between N,N-maleoyl amino acid esters and 1-(1-trimethylsiloxyvinyl)-3,4-dihydronaphthalene gave 11-(trimethylsiloxy) derivatives of 16-azaestra-1,3,5(10)-trienes. These were transformed by desilylation into the parent 11-oxo-deriva
Publikováno v:
Helvetica Chimica Acta. 88:2879-2891
The cycloaddition between N-protected 3-{1-[(trimethylsilyl)oxy]ethenyl}-1H-indoles and substituted maleimides (= 1H-pyrrole-2,5-diones) yielded substituted pyrrolo[3,4-a]carbazole derivatives bearing an additional succinimide (= pyrrolidine-2,5-dion