Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Hans, Gühring"'
Autor:
Jonathan, Barratt, James, Tumlin, Yusuke, Suzuki, Amy, Kao, Aida, Aydemir, Kishore, Pudota, Hulin, Jin, Hans, Gühring, Gerald, Appel
Publikováno v:
Kidney International Reports. 7:1831-1841
Patients with IgA nephropathy (IgAN) and persistent proteinuria are at risk of progression to kidney failure. Atacicept is a novel B-cell-targeted immunomodulator, shown to reduce immunoglobulin levels in patients with autoimmune diseases.JANUS (NCT0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4427ae83ec4c2fec49d0ac27607e31
https://doi.org/10.1016/j.ekir.2022.05.017
https://doi.org/10.1016/j.ekir.2022.05.017
Autor:
Anne Gigout, Daniela Werkmann, Stephanie Menges, Christian Brenneis, Frances Henson, Kyra J. Cowan, Djordje Musil, Christian S. Thudium, Hans Gühring, Martin Michaelis, Kerstin Kleinschmidt‐Doerr
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)REFERENCES.
To preclinically characterize a mutant form of growth and differentiation factor 5, R399E, with reduced osteogenic properties as a potential disease-modifying osteoarthritis (OA) drug.Cartilage, synovium, and meniscus samples from patients with OA we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd67f19e8ce2e025bc961c0a7fd27ee
https://pubmed.ncbi.nlm.nih.gov/36054172
https://pubmed.ncbi.nlm.nih.gov/36054172
Publikováno v:
BioResearch Open Access
For cartilage repair in vivo or evaluation of new therapeutic approaches in vitro, the generation of functional cartilage tissue is of crucial importance and can only be achieved if the phenotype of the chondrocytes is preserved. Three-dimensional (3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857d1f435ac52225b28e0a87cc980f0f
http://europepmc.org/articles/PMC7133430
http://europepmc.org/articles/PMC7133430
Autor:
Asger Reinstrup Bihlet, M.A. Karsdal, A.-C. Bay-Jensen, F. Moreau, Hans Gühring, Jeppe Ragnar Andersen
Publikováno v:
Annals of the Rheumatic Diseases. 79:800-801
Background:In osteoarthritis (OA), response to different interventions could be more pronounced in different endotypes of cartilage turnover. Data from UK biobank suggest that an endotype of low cartilage repair is associated with structural progress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0f227d49af3170e2783107e7f25f771
https://doi.org/10.1136/annrheumdis-2020-eular.3877
https://doi.org/10.1136/annrheumdis-2020-eular.3877
Autor:
Wolfgang Wirth, Hans Gühring, Felix Eckstein, Benjamin Daelken, F. Moreau, Philip G. Conaghan, Jeffrey Kraines, Christoph Ladel, Marc C. Hochberg
Publikováno v:
Oral Presentations.
Background Results from the 5-year Phase II FORWARD study showed significant dose-dependent modification of total femorotibial joint (TFTJ) cartilage thickness change with sprifermin at 2 and 3 years, by quantitative MRI. Total Western Ontario and Mc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db1a800c8ecb126703c00df8d415fb2e
https://doi.org/10.1136/annrheumdis-2019-eular.1216
https://doi.org/10.1136/annrheumdis-2019-eular.1216
Autor:
Philip G. Conaghan, Alan Brett, Hans Gühring, Jeffrey Kraines, Felix Eckstein, Michael A. Bowes, F. Moreau, Christoph Ladel
Publikováno v:
Saturday, 15 June 2019.
Background Sprifermin is under investigation as a potential disease-modifying osteoarthritis drug (DMOAD). 2-yr results from the FORWARD study showed significant dose-dependent modification of cartilage thickness in the total femorotibial joint (TFTJ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::690ec3e740ed6b1a6d19c109edf83c30
https://doi.org/10.1136/annrheumdis-2019-eular.1567
https://doi.org/10.1136/annrheumdis-2019-eular.1567
Autor:
Asger Reinstrup Bihlet, Hans Gühring, Christoph Ladel, Yunyun Luo, A. Manginelli, F. Moreau, M.A. Karsdal, Yi He, Jeppe Ragnar Andersen, A.-C. Bay-Jensen
Publikováno v:
Annals of the Rheumatic Diseases. 79:117.1-118
Background:It is challenging to monitor treatment effects after intra-articular (IA) injection with tissue modifying drugs. Assessment of biomarker levels in synovial fluid may be one solution to the challenge. Sprifermin is a truncated form of fibro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7333b4c37c4d0a6b8f9c8d1a27fcea3e
https://doi.org/10.1136/annrheumdis-2020-eular.3855
https://doi.org/10.1136/annrheumdis-2020-eular.3855
Autor:
Kathrin Meindl, Hans Gühring, George M. Sheldrick, Andreas Reicke, Timo Schmiederer, Joachim Wink, Simone Keller, Roderich D. Süssmuth, Holger Hoffmann, Diane Butz, Mark Brönstrup, Laszlo Vertesy, Kathrin Schneider
Publikováno v:
Angewandte Chemie International Edition. 49:1151-1154
Lantibiotics are peptides that are ribosomally synthesized from bacteria such as staphylococci, lactobacilli, and actinomycetes. The common structural characteristic of lantibiotics is the noncanonical amino acid lanthionine (Lan, 1; Figure 1), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde9f23baba023df8e6c8404ad903ec7
https://doi.org/10.1002/anie.200905773
https://doi.org/10.1002/anie.200905773
Autor:
Joachim Wink, Roderich D. Süssmuth, Kathrin Meindl, Hans Gühring, Mark Brönstrup, Andreas Reicke, Holger Hoffmann, Diane Butz, Timo Schmiederer, George M. Sheldrick, Simone Keller, Kathrin Schneider, Laszlo Vertesy
Publikováno v:
Angewandte Chemie. 122:1169-1173
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37cb7ba99c4522755aa15634f9c3f385
https://doi.org/10.1002/ange.200905773
https://doi.org/10.1002/ange.200905773
Autor:
Leif E, Dahlberg, Aida, Aydemir, Norma, Muurahainen, Hans, Gühring, Helena, Fredberg Edebo, Niels, Krarup-Jensen, Christoph H, Ladel, Jukka S, Jurvelin
Publikováno v:
Clinical and experimental rheumatology. 34(3)
To evaluate the safety of intra-articular sprifermin (primary), and to evaluate systemic exposure, biomarkers, histology, and other cartilage parameters in patients with advanced osteoarthritis (OA).This was a first-in-human, double-blind, randomised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::891cd1d5723fe52b470c394af2b6b497
https://pubmed.ncbi.nlm.nih.gov/27050139
https://pubmed.ncbi.nlm.nih.gov/27050139