Zobrazeno 1 - 10
of 341
pro vyhledávání: '"Hans, Deckmyn"'
Autor:
Grégoire de Streel, Charlotte Bertrand, Nicolas Chalon, Stéphanie Liénart, Orian Bricard, Sara Lecomte, Julien Devreux, Mélanie Gaignage, Gitte De Boeck, Lore Mariën, Inge Van De Walle, Bas van der Woning, Michael Saunders, Hans de Haard, Elien Vermeersch, Wim Maes, Hans Deckmyn, Pierre G. Coulie, Nicolas van Baren, Sophie Lucas
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Inhibiting TGF-β1 to increase immune responses against tumors bears the risk of tumor-promoting toxicity. Here the authors show that selectively blocking TGF-β1 produced by immunosuppressive cells is feasible with anti-GARP:TGF-β1 antibodies and i
Externí odkaz:
https://doaj.org/article/8a55d3ad04c940c5ae3df3fd9a81d1dc
Autor:
Marie‐Agnès Azerad, Firas Bayoudh, Thierry Weber, Jean‐Marc Minon, Olivier Ketelslegers, Marie Hoyoux, Xueying Ren, Olivier Kaye, Nils De Marneffe, Vincent Fraipont, Catherine Masset, Anne Sophie Bouillon, Aurélie Jaspers, Malek Tebache, Guillaume D'Hoen, Anousha Habibi, André Efira, Jecko Thachil, Hans Deckmyn, Yves Beguin
Publikováno v:
eJHaem, Vol 1, Iss 1, Pp 338-341 (2020)
Externí odkaz:
https://doaj.org/article/2fa7fe2121d5484689f74afd585547c0
Autor:
Myriam Chimen, Aigli Evryviadou, Clare L. Box, Matthew J. Harrison, Jon Hazeldine, Lea H. Dib, Sahithi J. Kuravi, Holly Payne, Joshua M.J. Price, Dean Kavanagh, Asif J. Iqbal, Sian Lax, Neena Kalia, Alex Brill, Steve G. Thomas, Antonio Belli, Nicholas Crombie, Rachel A. Adams, Shelley-Ann Evans, Hans Deckmyn, Janet M. Lord, Paul Harrison, Steve P. Watson, Gerard B. Nash, G. Ed Rainger
Publikováno v:
Haematologica, Vol 105, Iss 5 (2020)
Interactions between platelets, leukocytes and the vessel wall provide alternative pathological routes of thrombo-inflammatory leukocyte recruitment. We found that when platelets were activated by a range of agonists in whole blood, they shed platele
Externí odkaz:
https://doaj.org/article/148d3754311e4a4b82c8c3464dde2293
Autor:
Senna Staessens, Frederik Denorme, Olivier Francois, Linda Desender, Tom Dewaele, Peter Vanacker, Hans Deckmyn, Karen Vanhoorelbeke, Tommy Andersson, Simon F. De Meyer
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Ischemic stroke is caused by a thromboembolic occlusion of cerebral arteries. Treatment is focused on fast and efficient removal of the occluding thrombus, either via intravenous thrombolysis or via endovascular thrombectomy. Recanalization, however,
Externí odkaz:
https://doaj.org/article/e1e92a720b2d41afbc21552ce6cfc252
Autor:
Frederik Denorme, Kimberly Martinod, Aline Vandenbulcke, Cécile V. Denis, Peter J. Lenting, Hans Deckmyn, Karen Vanhoorelbeke, Simon F. De Meyer
Publikováno v:
Haematologica, Vol 106, Iss 3 (2020)
von Willebrand factor (VWF) plays an important role in ischemic stroke. However, the exact mechanism by which VWF mediates progression of ischemic stroke brain damage is not completely understood. Using flow cytometric analysis of single cell suspens
Externí odkaz:
https://doaj.org/article/c5f984ac37b94a639ce7a6347e4d62f8
Autor:
An-Sofie Schelpe, Elien Roose, Bérangère S. Joly, Inge Pareyn, Ilaria Mancini, Marina Biganzoli, Hans Deckmyn, Jan Voorberg, Rob Fijnheer, Flora Peyvandi, Simon F. De Meyer, Paul Coppo, Agnès Veyradier, Karen Vanhoorelbeke
Publikováno v:
Haematologica, Vol 104, Iss 6 (2019)
In autoantibody-mediated autoimmune diseases, autoantibody profiling allows patients to be stratified and links autoantibodies with disease severity and outcome. However, in immune-mediated thrombotic thrombocytopenic purpura (iTTP) patients, stratif
Externí odkaz:
https://doaj.org/article/762b34332b2847489d57a778da76fa64
Autor:
Elien Vermeersch, Benedicte P. Nuyttens, Claudia Tersteeg, Katleen Broos, Simon F. De Meyer, Karen Vanhoorelbeke, Hans Deckmyn
Publikováno v:
TH Open, Vol 02, Iss 03, Pp e272-e279 (2018)
Despite the absence of the genome in platelets, transcription profiling provides important insights into platelet function and can help clarify abnormalities in platelet disorders. The Bloodomics Consortium performed whole-genome expression analysis
Externí odkaz:
https://doaj.org/article/ee718168a00f4b22952fd10dc5672597
Autor:
Elien Roose, Claudia Tersteeg, Ruth Demeersseman, An-Sofie Schelpe, Louis Deforche, Inge Pareyn, Aline Vandenbulcke, Nele Vandeputte, Daan Dierickx, Jan Voorberg, Hans Deckmyn, Simon F. De Meyer, Karen Vanhoorelbeke
Publikováno v:
TH Open, Vol 02, Iss 01, Pp e8-e15 (2018)
Abstract In this study, we investigated a case of pregnancy-onset thrombotic thrombocytopenic purpura (TTP). The patient had severely decreased ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13) activity levels d
Externí odkaz:
https://doaj.org/article/1e8e322e788b4091aebd010e59ffcefd
Autor:
Frederik Denorme, Peter Kraft, Inge Pareyn, Christiane Drechsler, Hans Deckmyn, Karen Vanhoorelbeke, Christoph Kleinschnitz, Simon F De Meyer
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179258 (2017)
Von Willebrand Factor (VWF) plays a major role in thrombosis and hemostasis and its thrombogenicity is controlled by ADAMTS13. Whereas increasing evidence shows a clear association between VWF levels and acute ischemic stroke, little is known about a
Externí odkaz:
https://doaj.org/article/cd87ae1921014125ab6c2305e53e2fa5
Autor:
Elien Vermeersch, Frederik Denorme, Wim Maes, Simon F De Meyer, Karen Vanhoorelbeke, Justin Edwards, Ethan M Shevach, Derya Unutmaz, Hodaka Fujii, Hans Deckmyn, Claudia Tersteeg
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173329 (2017)
Glycoprotein-A Repetitions Predominant protein (GARP or LRRC32) is present on among others human platelets and endothelial cells. Evidence for its involvement in thrombus formation was suggested by full knockout of GARP in zebrafish.To evaluate the r
Externí odkaz:
https://doaj.org/article/067122cde4d94d89832a49c13ea7f81c