Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hanqian Mao"'
Autor:
Lei Xing, Jeremy M. Simon, Travis S. Ptacek, Jason J. Yi, Lipin Loo, Hanqian Mao, Justin M. Wolter, Eric S. McCoy, Smita R. Paranjape, Bonnie Taylor-Blake, Mark J. Zylka
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112706- (2023)
Summary: The E3 ubiquitin ligase Ube3a is biallelically expressed in neural progenitors and glial cells, suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental disorders irrespective of parent of origin. Here, we engineered a
Externí odkaz:
https://doaj.org/article/e51c03b71c704840a187f7c84c88daee
Autor:
Giulia Fragola, Angela M. Mabb, Bonnie Taylor-Blake, Jesse K. Niehaus, William D. Chronister, Hanqian Mao, Jeremy M. Simon, Hong Yuan, Zibo Li, Michael J. McConnell, Mark J. Zylka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Topoisomerase 1 (TOP1) relieves DNA torsional stress during transcription and facilitates the expression of long neuronal genes. Here we show that deletion of Top1 in excitatory neurons leads to early onset neurodegeneration that is partially depende
Externí odkaz:
https://doaj.org/article/0fddde2332ce490c801aa1485380dfc3
Autor:
Matthew J. Buccilli, April N. Ilacqua, Mingxi Han, Andrew A. Banas, Elise M. Wight, Hanqian Mao, Samantha P. Perry, Tasha S. Salter, David R. Loiselle, Timothy A.J. Haystead, Cynthia K. Damer
Publikováno v:
Cells, Vol 8, Iss 7, p 758 (2019)
Copines make up a family of calcium-dependent, phospholipid-binding proteins found in numerous eukaryotic organisms. Copine proteins consist of two C2 domains at the N-terminus followed by an A domain similar to the von Willebrand A domain found in i
Externí odkaz:
https://doaj.org/article/4bb9c1b3bb4d44dc8325f7fd4b3adb23
Publikováno v:
PLoS Genetics, Vol 12, Iss 9, p e1006282 (2016)
The exon junction complex (EJC) is an RNA binding complex comprised of the core components Magoh, Rbm8a, and Eif4a3. Human mutations in EJC components cause neurodevelopmental pathologies. Further, mice heterozygous for either Magoh or Rbm8a exhibit
Externí odkaz:
https://doaj.org/article/587bd40faf2d4850899db0ea91df6b61
Autor:
Mark J. Zylka, Angela M. Mabb, Bonnie Taylor-Blake, William D. Chronister, Jeremy M. Simon, Hong Yuan, Zibo Li, Michael J. McConnell, Giulia Fragola, Jesse K. Niehaus, Hanqian Mao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Topoisomerase 1 (TOP1) relieves torsional stress in DNA during transcription and facilitates the expression of long (>100 kb) genes, many of which are important for neuronal functions. To evaluate how loss of Top1 affected neurons in vivo, we conditi
Autor:
Justin M. Wolter, Baris Oztemiz, Hannah O. Bazick, James L. Krantz, Hanqian Mao, Giulia Fragola, Jeremy M. Simon, Jason L. Stein, Mark J. Zylka
Publikováno v:
Nature
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by a mutation or deletion of the maternally inherited UBE3A allele. In neurons, the paternally inherited UBE3A allele is silenced in cis by a long non-coding RNA called UBE3A-ATS.
Autor:
April N. Ilacqua, Matthew J Buccilli, Tasha S. Salter, Elise M. Wight, Mingxi Han, Samantha P. Perry, David R. Loiselle, Andrew A. Banas, Cynthia K. Damer, Hanqian Mao, Timothy A.J. Haystead
Publikováno v:
Cells, Vol 8, Iss 7, p 758 (2019)
Cells
Volume 8
Issue 7
Cells
Volume 8
Issue 7
Copines make up a family of calcium-dependent, phospholipid-binding proteins found in numerous eukaryotic organisms. Copine proteins consist of two C2 domains at the N-terminus followed by an A domain similar to the von Willebrand A domain found in i
Autor:
Christelle Golzio, Nicholas Katsanis, Hanqian Mao, Danwei Wu, Lei Shi, John J. McMahon, Louis-Jan Pilaz, Debra L. Silver
Publikováno v:
The Journal of Neuroscience. 35:7003-7018
The cerebral cortex is built during embryonic neurogenesis, a period when excitatory neurons are generated from progenitors. Defects in neurogenesis can cause acute neurodevelopmental disorders, such as microcephaly (reduced brain size). Altered dosa
Publikováno v:
WIREs Developmental Biology. 7
Embryonic development is a critical period during which neurons of the brain are generated and organized. In the developing cerebral cortex, this requires complex processes of neural progenitor proliferation, neuronal differentiation, and migration.
Publikováno v:
RNA (New York, N.Y.). 23(1)
The exon junction complex (EJC) is a multiprotein complex integral to mRNA metabolism. Biochemistry and genetic studies have concluded that the EJC is composed of four core proteins, MAGOH, EIF4A3, RBM8A, and CASC3. Yet recent studies in Drosophila i