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Abstract 2297: Anti-labyrinthin monoclonal antibody reduces human adenocarcinoma circulating tumor cells in the blood of patient-derived xenograft models and inhibits the growth of adenocarcinoma cell cultures

Autor: Solomon M. Stemmer, Hanoch Slor, Evgeny Solomonov, Netta R. Blondheim-Shraga, Izhak Haviv, Natalia Saleev, Shiran Shapira

Publikováno v: Cancer Research. 79:2297-2297

Labyrinthin is a 255-amino acid protein antigen that is expressed on the cell-surface of most adenocarcinoma tumors and is not expressed on the surface of most normal cells, which makes it an attractive candidate for targeted therapy. Originally, lab

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https://doi.org/10.1158/1538-7445.am2019-2297

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A novel XPD mutation in a compound heterozygote; the mutation in the second allele is present in three homozygous patients with mild sun sensitivity

Autor: Graciela Spivak, Reut Erel-Segal, Limor Kalfon, Zvi Segal, Sivan Koka, Bella Gross, Shlomi Orgal, Zohar Keren, Ora Bitterman-Deutsch, Sara Chaim, Yishay Shoval, Hanoch Slor, Tzipora C Falik-Zaccai, Liran Horev, Philip C. Hanawalt

Publikováno v: Environmental and Molecular Mutagenesis. 53:505-514

The XPD protein plays a pivotal role in basal transcription and in nucleotide excision repair (NER) as one of the ten known components of the transcription factor TFIIH. Mutations in XPD can result in the DNA repair-deficient diseases xeroderma pigme

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https://doi.org/10.1002/em.21716

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Xeroderma Pigmentosum-Variant Patients from America, Europe, and Asia

Publikováno v: Journal of Investigative Dermatology. 128(8):2055-2068

Xeroderma pigmentosum-variant (XP-V) patients have sun sensitivity and increased skin cancer risk. Their cells have normal nucleotide excision repair, but have defects in the POLH gene encoding an error-prone polymerase, DNA polymerase eta (pol eta).

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A locus for complicated hereditary spastic paraplegia maps to chromosome 1q24-q32

Autor: Evan Reid, P. Nisipeanu, Aziz Mazarib, David Withers, Sergiu C. Blumen, Saif Abu-Mouch, Michael Kahana, Rifka Inzelberg, Simon Bevan, R.L. Carasso, Ruth Navon, David Negus, Ahmad Mahamid, Hanoch Slor

Publikováno v: Annals of Neurology. 54:796-803

We updated the clinical features of a consanguineous Arab Israeli family, in which four of seven children were affected by spastic paraplegia complicated by skin pigmentary abnormalities. A genomewide linkage screen performed for the family identifie

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https://doi.org/10.1002/ana.10768

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Relationship of Neurologic Degeneration to Genotype in Three Xeroderma Pigmentosum Group G Patients

Autor: Myung-Moo Lee, Steffen Emmert, Roberta Bliss Albert, John J. DiGiovanna, David B. Busch, Jill Crollick, Bassam Abu-Libdeh, Sikandar G. Khan, Hanoch Slor, Takahiro Ueda, Sima Batko, Donna M. Coleman, Bari B. Cunningham, Lawrence Grossman, Kenneth H. Kraemer, Mohammad Hedayati, James E. Cleaver, Hiroki Inui, Tala Shahlavi

Publikováno v: Journal of Investigative Dermatology. 118:972-982

We studied three newly diagnosed xeroderma pigmentosum complementation group G patients with markedly different clinical features. An Israeli-Palestinian girl (XP96TA) had severe abnormalities suggestive of the xeroderma pigmentosum/Cockayne syndrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0a803677abd6c18e1e20e274a26537
https://doi.org/10.1046/j.1523-1747.2002.01782.x

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Lack of correlation between apoptosis and DNA single-strand breaks in X-irradiated human peripheral blood mononuclear cells in the course of ageing

Autor: Evelyn Heidenreich, Hanoch Slor, Christian Chauvin, Joachim Kutzner, Heinz C. Schröder, Renato Batel, Kristina Elmendorff-Dreikorn

Publikováno v: Mechanisms of Ageing and Development. 106:117-128

The dependence on age of both the basal and the X-radiation-induced levels of apoptosis was examined in human peripheral blood mononuclear cells (PBMC). In the same samples, the base value and the extent of induced DNA single-strand breaks were deter

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https://doi.org/10.1016/s0047-6374(98)00110-9

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Prevalence of 13 autoantibodies and of the 16/6 and related pathogenic idiotypes in 465 patients with systemic lupus erythematosus and their relationship with disease activity

Autor: G M Villarreal, Hanoch Slor, Y Shoenfeld, A R Villa, R. Bakimer, Cristina Drenkard, Donato Alarcón-Segovia, Shafrir S

Publikováno v: Lupus. 6:425-435

With a cross sectional study of 465 consecutive systemic lupus erythematosus (SLE) patients tested for 13 autoantibodies (Aab) and two idiotypes we determined the prevalence of Aab according to disease activity, both general and at particular organ s

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https://doi.org/10.1177/096120339700600503

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Anticardiolipin antibodies are elevated in drug-free, multiply affected families with schizophrenia

Autor: Pinkhas Sirota, Klara Schild, Michael A. Firer, Avner Elizur, Hanoch Slor

Publikováno v: Journal of Clinical Immunology. 14:73-78

The objective of this study was to measure anticardiolipin antibodies in patients and healthy relatives in multicase families with schizophrenia. Twenty-eight (28) multicase families with schizophrenia were examined. One hundred three drug-free patie

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https://doi.org/10.1007/bf01541177

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Werner's syndrome (adult progeria): An affected mother and son presenting with resistant psychosis

Autor: Pinkhas Sirota, R. Kimhi, Yoram Barak, Hanoch Slor

Publikováno v: Comprehensive Psychiatry, Vol 42, Iss 6, Pp 508-510 (2001)

Age-related psychotic conditions may be studied by focusing on the unique group of progeroid syndromes. This report will focus on Werner's syndrome, one of the better defined and studied progeroid syndromes. We applied clinical and histophysiological

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https://doi.org/10.1053/comp.2001.27895

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