Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hanny Wassef"'
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 6, Pp 1074-1085 (2016)
Reduced white adipose tissue (WAT) LPL activity delays plasma clearance of TG-rich lipoproteins (TRLs). We reported the secretion of apoC-I, an LPL inhibitor, from WAT ex vivo in women. Therefore we hypothesized that WAT-secreted apoC-I associates wi
Externí odkaz:
https://doaj.org/article/f51ce28a327a468cb5a25197d1a0eba7
Autor:
Simon Bissonnette, Huda Salem, Hanny Wassef, Nathalie Saint-Pierre, Annie Tardif, Alexis Baass, Robert Dufour, May Faraj
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1466-1476 (2013)
Delayed clearance of triglyceride-rich lipoprotein (TRL) by white adipose tissue (WAT) promotes hypertriglyceridemia and elevated apoB-lipoproteins, which are primarily in the form of LDL. This study examines whether LDL promotes delayed clearance of
Externí odkaz:
https://doaj.org/article/3d6e5e7b3d1b4d069cf9c4d624aa76b7
Autor:
Nabil G Seidah, Steve Poirier, Maxime Denis, Rex Parker, Bowman Miao, Claudio Mapelli, Annik Prat, Hanny Wassef, Jean Davignon, Katherine A Hajjar, Gaétan Mayer
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41865 (2012)
Proprotein convertase subtilisin/kexin-9 (PCSK9) enhances the degradation of hepatic low-density lipoprotein receptor (LDLR). Deletion of PCSK9, and loss-of-function mutants in humans result in lower levels of circulating LDL-cholesterol and a strong
Externí odkaz:
https://doaj.org/article/01c0adcef4634440bdb84bf935f462b6
Autor:
Yannick Cyr, Emmanuelle Loizon, Gaétan Mayer, Valérie Lamantia, Emilienne Tudor Ngo Sock, Simon Bissonnette, Hubert Vidal, Michel Chrétien, Hanny Wassef, May Faraj
Publikováno v:
Obesity
Obesity, Wiley, 2020, 28 (12), pp.2357-2367. ⟨10.1002/oby.22985⟩
Obesity, Wiley, 2020, 28 (12), pp.2357-2367. ⟨10.1002/oby.22985⟩
International audience; Objective Human conditions with upregulated receptor uptake of low-density lipoproteins (LDL) are associated with diabetes risk, the reasons for which remain unexplored. LDL induce metabolic dysfunction in murine adipocytes. T
Autor:
Brandon Ason, Joshua Dobroff, Khrystyna Platko, Susan Shetterly, Wadih Arap, Paul F. Lebeau, Jae Hyun Byun, Hanny Wassef, Simon Jackson, Richard C. Austin, Nabil G. Seidah, Michel Chrétien, Renata Pasqualini, Kevin Doyoon Won, Annik Prat, Guillaume Paré, William G. Richards, Ali Al-Hashimi, An Tang, Majambu Mbikay
Publikováno v:
J Clin Invest
Individuals harboring the loss-of-function (LOF) proprotein convertase subtilisin/kexin type 9 Gln152His variation (PCSK9(Q152H)) have low circulating low-density lipoprotein cholesterol levels and are therefore protected against cardiovascular disea
Autor:
M. Chrétien, Lioudmila Tepliakova, Daniel Figeys, Hussein Abujrad, Deeptee Seebun, Janice Mayne, Hanny Wassef, Majambu Mbikay, Teik Chye Ooi, Dhanuddara Mohottalage, Krystal Walker, Zhibin Ning
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 103:3486-3495
Elevated circulating cholesterol-rich low-density lipoprotein (LDL) particles increase coronary artery disease risk. Cell-surface hepatic LDL receptors (LDLRs) clear 70% of these particles from circulation. The ectodomain of LDLR is shed into circula
Autor:
May Faraj, Nathalie Saint-Pierre, Hanny Wassef, Michel Chrétien, Yannick Cyr, Simon Bissonnette, Valérie Lamantia
Publikováno v:
Journal of Clinical Lipidology. 9:664-675
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) shuttles low-density lipoprotein (LDL) receptors for degradation, thus upregulates LDL plasma clearance. Although PCSK9 loss of function is cardioprotective, its role in metabolic risks
Publikováno v:
Journal of Clinical Lipidology. 8:510-519
We previously reported the secretion of apolipoprotein apoC-I, apoC-II, apoC-III, and apoE from adipose tissue in postmenopausal obese women, suggesting their potential regulation by energy balance in humans.We examined the changes of these apolipopr
Autor:
Huda Salem, Nathalie Saint-Pierre, May Faraj, Alexis Baass, Hanny Wassef, Robert Dufour, Annie Tardif, Simon Bissonnette
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1466-1476 (2013)
Delayed clearance of triglyceride-rich lipoprotein (TRL) by white adipose tissue (WAT) promotes hypertriglyceridemia and elevated apoB-lipoproteins, which are primarily in the form of LDL. This study examines whether LDL promotes delayed clearance of
Autor:
Rémi Rabasa-Lhoret, Robert Dufour, Simon Bissonnette, Alexis Baass, Valérie Lamantia, May Faraj, Hanny Wassef, Yannick Cyr
Publikováno v:
Endocrine Abstracts.