Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Hanny Odijk"'
Autor:
Maarten W Paul, Arshdeep Sidhu, Yongxin Liang, Sarah E van Rossum-Fikkert, Hanny Odijk, Alex N Zelensky, Roland Kanaar, Claire Wyman
Publikováno v:
eLife, Vol 10 (2021)
Breast cancer type two susceptibility protein (BRCA2) is an essential protein in genome maintenance, homologous recombination (HR), and replication fork protection. Its function includes multiple interaction partners and requires timely localization
Externí odkaz:
https://doaj.org/article/b6b37d495f8f43f28cdbe0c08ec1c3b6
Autor:
Inger Brandsma, Koichi Sato, Sari E. van Rossum-Fikkert, Nicole van Vliet, Esther Sleddens, Marcel Reuter, Hanny Odijk, Nathalie van den Tempel, Dick H.W. Dekkers, Karel Bezstarosti, Jeroen A.A. Demmers, Alex Maas, Joyce Lebbink, Claire Wyman, Jeroen Essers, Dik C. van Gent, Willy M. Baarends, Puck Knipscheer, Roland Kanaar, Alex N. Zelensky
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3790-3798.e7 (2019)
Summary: The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability, and DNA interstrand crosslink repair in vertebrates. We identify HSF2BP, a protein previously described as testis specific and not charact
Externí odkaz:
https://doaj.org/article/2637c90b510241f59a26f31c229eef63
Autor:
Dik C. van Gent, Roland Kanaar, Nitika Taneja, Ronald Dekker, Jos Jonkers, Wytske M. van Weerden, Corrina M.A. de Ridder, Marieke van de Ven, Hanny Odijk, Nikolas Gaio, Anja van de Stolpe, Cinzia Silvestri, Amr Othman, Calvin Shun Yu Lo, Sandeep Mallya, Ben Haspels, Maayke M.P. Kuijten, William F. Quiros-Solano, Sanjiban Chakrabarty
Optimal treatment of cancer requires diagnostic methods to facilitate therapy choice and prevent ineffective treatments. Direct assessment of therapy response in viable tumor specimens could fill this diagnostic gap. Therefore, we designed a microflu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856c33ac8068b1d249946cf2013dd8f8
https://doi.org/10.1158/0008-5472.c.6570593.v1
https://doi.org/10.1158/0008-5472.c.6570593.v1
Autor:
Dik C. van Gent, Roland Kanaar, Nitika Taneja, Ronald Dekker, Jos Jonkers, Wytske M. van Weerden, Corrina M.A. de Ridder, Marieke van de Ven, Hanny Odijk, Nikolas Gaio, Anja van de Stolpe, Cinzia Silvestri, Amr Othman, Calvin Shun Yu Lo, Sandeep Mallya, Ben Haspels, Maayke M.P. Kuijten, William F. Quiros-Solano, Sanjiban Chakrabarty
Supplementary files
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276c90c7ed5f2e12f74e37f61d99dcaf
https://doi.org/10.1158/0008-5472.22582460.v1
https://doi.org/10.1158/0008-5472.22582460.v1
Autor:
Sanjiban Chakrabarty, William F. Quiros-Solano, Maayke M.P. Kuijten, Ben Haspels, Sandeep Mallya, Calvin Shun Yu Lo, Amr Othman, Cinzia Silvestri, Anja van de Stolpe, Nikolas Gaio, Hanny Odijk, Marieke van de Ven, Corrina M.A. de Ridder, Wytske M. van Weerden, Jos Jonkers, Ronald Dekker, Nitika Taneja, Roland Kanaar, Dik C. van Gent
Publikováno v:
Cancer Research, 82(3)
Cancer Research, 82(3), 510-520. American Association for Cancer Research Inc.
Cancer Research, 82(3), 510-520. American Association for Cancer Research Inc.
Optimal treatment of cancer requires diagnostic methods to facilitate therapy choice and prevent ineffective treatments. Direct assessment of therapy response in viable tumor specimens could fill this diagnostic gap. Therefore, we designed a microflu
Autor:
Maarten W. Paul, Claire Wyman, Yongxin Liang, Roland Kanaar, Hanny Odijk, Sarah E van Rossum-Fikkert, Arshdeep Sidhu, Alex N. Zelensky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28befe30d4df0f904f14a6d0bf2b6eb9
https://doi.org/10.7554/elife.67926.sa2
https://doi.org/10.7554/elife.67926.sa2
Autor:
Roland Kanaar, Claire Wyman, Hanny Odijk, Arshdeep Sidhu, Sarah E van Rossum-Fikkert, Yongxin Liang, Maarten W. Paul, Alex N. Zelensky
Publikováno v:
eLife
eLife, 10:e67926. eLife Sciences Publications
eLife, Vol 10 (2021)
eLife, 10:e67926. eLife Sciences Publications
eLife, Vol 10 (2021)
Breast cancer type two susceptibility protein (BRCA2) is an essential protein in genome maintenance, homologous recombination (HR), and replication fork protection. Its function includes multiple interaction partners and requires timely localization
Autor:
Claire Wyman, Maarten W. Paul, Sarah E van Rossum-Fikkert, Alex N. Zelensky, Arshdeep Sidhu, Roland Kanaar, Hanny Odijk, Yongxin Liang
BRCA2 is an essential protein in genome maintenance, homologous recombination and replication fork protection. Its function includes multiple interaction partners and requires timely localization to relevant sites in the nucleus. We investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a4cb9bb0470c876f422d65a79ff68e6
https://doi.org/10.1101/2021.03.02.433541
https://doi.org/10.1101/2021.03.02.433541
Autor:
Charlie Laffeber, Wiggert A. van Cappellen, Roland Kanaar, Martine Franckena, Hanny Odijk, Gerard C. van Rhoon, Nathalie van den Tempel
Publikováno v:
Oncotarget
Oncotarget, 8(27), 44593-44604. Impact Journals LLC
Oncotarget, 8(27), 44593-44604. Impact Journals LLC
Hyperthermia has a number of biological effects that sensitize tumors to radiotherapy in the range between 40-44 °C. One of these effects is heat-induced degradation of BRCA2 that in turn causes reduced RAD51 focus formation, which results in an att
Autor:
Hanny Odijk, Charlie Laffeber, Przemek M. Krawczyk, Roland Kanaar, Nathalie van den Tempel, Inger Brandsma, Christine K. Schmidt, Jeroen Demmers, Alex N. Zelensky
Publikováno v:
Cancers, 11(1):97. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers
Volume 11
Issue 1
Cancers, Vol 11, Iss 1, p 97 (2019)
Van Den Tempel, N, Zelensky, A N, Odijk, H, Laffeber, C, Schmidt, C K, Brandsma, I, Demmers, J, Krawczyk, P M & Kanaar, R 2019, ' On the mechanism of hyperthermia-induced BRCA2 protein degradation ', Cancers, vol. 11, no. 1, 97 . https://doi.org/10.3390/cancers11010097
Cancers
Volume 11
Issue 1
Cancers, Vol 11, Iss 1, p 97 (2019)
Van Den Tempel, N, Zelensky, A N, Odijk, H, Laffeber, C, Schmidt, C K, Brandsma, I, Demmers, J, Krawczyk, P M & Kanaar, R 2019, ' On the mechanism of hyperthermia-induced BRCA2 protein degradation ', Cancers, vol. 11, no. 1, 97 . https://doi.org/10.3390/cancers11010097
The DNA damage response (DDR) is a designation for a number of pathways that protects our DNA from various damaging agents. In normal cells, the DDR is extremely important for maintaining genome integrity, but in cancer cells these mechanisms counter