Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Hannu Sariola"'
Autor:
Astrid Murumägi, Daniela Ungureanu, Mariliina Arjama, Ralf Bützow, Jouko Lohi, Hannu Sariola, Jukka Kanerva, Minna Koskenvuo, Olli Kallioniemi
Publikováno v:
Translational Oncology, Vol 14, Iss 4, Pp 101027- (2021)
Genetic rearrangements involving the anaplastic lymphoma kinase (ALK) gene create oncogenic drivers for several cancers, including malignant peritoneal mesothelioma (MPeM). Here, we report genomic and functional precision oncology profiling on a rare
Externí odkaz:
https://doaj.org/article/333af32b89cc40249fd01611041baefc
Autor:
Hannu Sariola, Satu Wedenoja, Juha Kere, Nina Linder, Johan Lundin, Caj Haglund, Tuomas Kaprio
Publikováno v:
HLA. 98:213-217
Trophoblast-specific expression of human leukocyte antigen G (HLA-G) induces immune tolerance for the developing fetus. Pathological HLA-G expression later in life might contribute to immune escape of various cancers. We studied the still controversi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ccc3644554edaa751827058dee9a2d
https://doi.org/10.1111/tan.14334
https://doi.org/10.1111/tan.14334
Autor:
Anmol Kumar, Satu Kuure, Hannu Sariola, Yujuan Gui, Petra Sipilä, Jaan-Olle Andressoo, Hao Li, Roxana Ola, Madis Jakobson
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Mechanisms controlling ureter lenght and the position of the kidney are poorly understood. Glial cell-line derived neurotrophic factor (GDNF) induced RET signaling is critical for ureteric bud outgrowth, but the function of endogenous GDNF in further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3add9908784710903c7b78c7e3b1c7f2
http://link.springer.com/article/10.1038/s41598-019-40457-1
http://link.springer.com/article/10.1038/s41598-019-40457-1
Autor:
Daniela Ungureanu, Hannu Sariola, Astrid Murumägi, Minna Koskenvuo, Olli Kallioniemi, Jukka Kanerva, Mariliina Arjama, Ralf Bützow, Jouko Lohi
Publikováno v:
Translational Oncology
Translational Oncology, Vol 14, Iss 4, Pp 101027-(2021)
Translational Oncology, Vol 14, Iss 4, Pp 101027-(2021)
Highlights • First study to establish in real-time STRN-ALK fusion positive pediatric patient-derived cancer cells (PDCs). • Ex vivo sensitivity testing of PDCs to 527 oncology drugs was analysed by high-throughput drug testing. • Comparison of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8b98e6534d26d81bcc08e02649f702
https://pubmed.ncbi.nlm.nih.gov/33530027
https://pubmed.ncbi.nlm.nih.gov/33530027
Autor:
Hannu Sariola, Satu Kuure
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9789811523885
Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects, which cause the majority of chronic kidney diseases in children. CAKUT covers a wide range of malformations that derive from deficiencies in embryonic kidney and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cd117b520e99ef4b1848c9d441eee2
https://doi.org/10.1007/978-981-15-2389-2_5
https://doi.org/10.1007/978-981-15-2389-2_5
Autor:
Sini Ezer, Nina Linder, Hindrek Teder, Shintaro Katayama, Juho Wedenoja, Seppo Heinonen, Erik Iwarsson, Masahito Yoshihara, Mikael Mokkonen, Eero Kajantie, Johan Lundin, Hannele Laivuori, Tiina Skoog, Juha Kere, Mika Gissler, Kaarel Krjutškov, Hannu Sariola, Inka M. K. Häkkinen, Karin Pettersson, Satu Wedenoja, Ellika Sahlin
Publikováno v:
EBioMedicine
Background Fetal immune tolerance is crucial for pregnancy success. We studied the link between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal human leukocyte antigen G (HLA-G) and other genes regulating maternal imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ef6f0bd6d62b49fabd6498650d6476
http://urn.fi/urn:nbn:fi-fe2020120399318
http://urn.fi/urn:nbn:fi-fe2020120399318
Autor:
Kirsi Sainio, Satu Kuure, Maciej Lalowski, Arvydas Dapkunas, Ville Rantanen, Yujuan Gui, Hannu Sariola
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Kidney mesenchyme (KM) and nephron progenitors (NPs) depend on WNT activity, and their culture in vitro requires extensive repertoire of recombinant proteins and chemicals. Here we established a robust, simple culture of mouse KM using a combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85760cf819c8ce539121e53b99616f2f
http://link.springer.com/article/10.1038/s41598-019-49526-x
http://link.springer.com/article/10.1038/s41598-019-49526-x
Autor:
Satu, Kuure, Hannu, Sariola
Publikováno v:
Advances in experimental medicine and biology. 1236
Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects, which cause the majority of chronic kidney diseases in children. CAKUT covers a wide range of malformations that derive from deficiencies in embryonic kidney and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ffba49a627e0616d7f3304e670fec5d6
https://pubmed.ncbi.nlm.nih.gov/32304071
https://pubmed.ncbi.nlm.nih.gov/32304071
Autor:
Eero Kajantie, Inka M. K. Häkkinen, Seppo Heinonen, Ellika Sahlin, Hannele Laivuori, Hannu Sariola, Shintaro Katayma, Mikael Mokkonen, Kaarel Krjutškov, Masahito Yoshihara, Juha Kere, Juho Wedenoja, Mika Gissler, Karin Pettersson, Satu Wedenoja, Tiina Skoog, Hindrek Teder, Nina Linder, Erik Iwarsson, Sini Ezer, Johan Lundin
The population sex ratio is thought to be maintained through balancing selection on rare phenotypes. However, empirical evidence for genetic influence has thus far proven elusive. We combined 1000 Genomes data and large cohorts to study human sex rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf21fa8fe8f202ad12702553782b7c2
https://doi.org/10.1101/851089
https://doi.org/10.1101/851089
Autor:
Jarkko Ustinov, Hannu Sariola, Päivi J. Miettinen, Decio L. Eizirik, Elina Hakonen, Timo Otonkoski
Publikováno v:
Diabetologia. 57:970-979
EGF receptor (EGFR) signalling is required for normal beta cell development and postnatal beta cell proliferation. We tested whether beta cell proliferation can be triggered by EGFR activation at any age and whether this can protect beta cells agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c8163d00a5090c015887399082f2f2
https://doi.org/10.1007/s00125-014-3175-2
https://doi.org/10.1007/s00125-014-3175-2