Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Hannu Mönkkönen"'
Purpose: Nitrogen-containing bisphosphonates (N-BP) such as zoledronate and risedronate exhibit antitumor effects. They block the activity of farnesyl pyrophosphate synthase (FPPS) in the mevalonate pathway, leading to intracellular accumulation of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b93263f775bab4c9ead34578a6ff43
https://doi.org/10.1158/1078-0432.c.6520607.v1
https://doi.org/10.1158/1078-0432.c.6520607.v1
PDF file - 173K, IPP/ApppI phosphoantigen accumulation induced by RIS and cellular uptake of RIS in breast cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64740efbf2426838c9f33cf6dec5241a
https://doi.org/10.1158/1078-0432.22445951.v1
https://doi.org/10.1158/1078-0432.22445951.v1
PDF file - 844K, Expression of adhesion molecules in cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c23d91ce57f31ef329c014be15d3f6b
https://doi.org/10.1158/1078-0432.22445948
https://doi.org/10.1158/1078-0432.22445948
PDF file - 195K, RIS induced Vγ9Vδ2 T-cell expansion in vitro and IPP/ApppI production in human PBMCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c9b0693380684a83e5555832614649
https://doi.org/10.1158/1078-0432.22445954.v1
https://doi.org/10.1158/1078-0432.22445954.v1
Autor:
Philippe Clézardin, Jean-Louis Touraine, Jukka Mönkkönen, Jonathan Green, Edith Bonnelye, Verena Stresing, Hannu Mönkkönen, Ismahène Benzaïd
Supplementary Figure Legend from High Phosphoantigen Levels in Bisphosphonate-Treated Human Breast Tumors Promote Vγ9Vδ2 T-Cell Chemotaxis and Cytotoxicity In Vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eaaadba85fc436cba920838b01dc9cf
https://doi.org/10.1158/0008-5472.22388792
https://doi.org/10.1158/0008-5472.22388792
Autor:
Philippe Clézardin, Jean-Louis Touraine, Jukka Mönkkönen, Jonathan Green, Edith Bonnelye, Verena Stresing, Hannu Mönkkönen, Ismahène Benzaïd
Supplementary Figure 1 from High Phosphoantigen Levels in Bisphosphonate-Treated Human Breast Tumors Promote Vγ9Vδ2 T-Cell Chemotaxis and Cytotoxicity In Vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e04b6893282f77de4b64cbebc9e24b5
https://doi.org/10.1158/0008-5472.22388795.v1
https://doi.org/10.1158/0008-5472.22388795.v1
Autor:
Hannu Mönkkönen, Johanna Räikkönen, Philippe Clézardin, Jorma A. Määttä, Ismahene Benzaid, Satu Arkko, Hristo Zlatev, Jukka Mönkkönen
Publikováno v:
Cancer Letters. 357(1):279-285
Zoledronate (ZOL) inhibits farnesyl pyrophosphate synthase leading to intracellular accumulation of isopentenyl pyrophosphate/triphosphoric acid 1-adenosin-5'-yl ester 3-(3-methylbut-3-enyl) ester (IPP/ApppI). Cytotoxic Vγ9Vδ2 T cells have been sho
Publikováno v:
Clinical Cancer Research. 18:6249-6259
Purpose: Nitrogen-containing bisphosphonates (N-BP) such as zoledronate and risedronate exhibit antitumor effects. They block the activity of farnesyl pyrophosphate synthase (FPPS) in the mevalonate pathway, leading to intracellular accumulation of m
Publikováno v:
Biochemical Pharmacology. 79:777-783
Increasing evidence is accumulating that zoledronic acid (ZOL), a nitrogen-containing bisphosphonate (N-BP), is able to affect tumor cells by inhibiting the enzyme farnesyl pyrophosphate synthase (FPPS) in the mevalonate pathway (MVP). The consequent