Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Hannu, Maaheimo"'
Publikováno v:
AMB Express, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract The oxidative d-xylose pathway, i.e. Dahms pathway, can be utilised to produce from cheap biomass raw material useful chemical intermediates. In vitro metabolic pathways offer a fast way to study the rate-limiting steps and find the most sui
Externí odkaz:
https://doaj.org/article/84061153233442359e6f38f12ba46191
Autor:
Helena Tossavainen, Vytas Raulinaitis, Linda Kauppinen, Ulla Pentikäinen, Hannu Maaheimo, Perttu Permi
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
Lysostaphin from Staphylococcus simulans and its family enzymes rapidly acquire prominence as the next generation agents in treatment of S. aureus infections. The specificity of lysostaphin is promoted by its C-terminal cell wall targeting domain sel
Externí odkaz:
https://doaj.org/article/b3f4379311744fbf8bdfbd06daca87ab
Autor:
Mirkka Sarparanta, Surachet Imlimthan, Iris Katariina Sokka, Filip S. Ekholm, Mikael P. Johansson, Hannu Maaheimo
Publikováno v:
Sokka, I K, Imlimthan, S, Sarparanta, M, Maaheimo, H, Johansson, M P & Ekholm, F S 2021, ' Halogenation at the phenylalanine residue of monomethyl auristatin f leads to a favorable cis/ trans equilibrium and retained cytotoxicity ', Molecular Pharmaceutics, vol. 18, no. 8, pp. 3125-3131 . https://doi.org/10.1021/acs.molpharmaceut.1c00342
Molecular Pharmaceutics
Molecular Pharmaceutics
Halogenation can be utilized for the purposes of labeling and molecular imaging, providing a means to, e.g., follow drug distribution in an organism through positron emission tomography (PET) or study the molecular recognition events unfolding by nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95f58ef077c9074a6334b247722d50d
https://doi.org/10.1021/acs.molpharmaceut.1c00342
https://doi.org/10.1021/acs.molpharmaceut.1c00342
Autor:
Amir Akhgari, Into Laakso, Hannu Maaheimo, Young Hae Choi, Tuulikki Seppänen-Laakso, Kirsi-Marja Oksman-Caldentey, Heiko Rischer
Publikováno v:
Plants, Vol 8, Iss 12, p 534 (2019)
Methyl jasmonate is capable of initiating or improving the biosynthesis of secondary metabolites in plants and therefore has opened up a concept for the biosynthesis of valuable constituents. In this study, the effect of different doses of methyl jas
Externí odkaz:
https://doaj.org/article/d1ec868d564c48feba9ee3f29c4c423c
Autor:
Emmi Jokinen, Sanni Voutilainen, Markus Heinonen, Hannu Maaheimo, Anu Koivula, Martina Andberg, Juho Rousu, Juha Rouvinen, Merja Penttilä, Harri Lähdesmäki, Samuel Kaski, Johan Pääkkönen, Nina Hakulinen
Publikováno v:
Applied Microbiology and Biotechnology
Voutilainen, S, Heinonen, M, Andberg, M, Jokinen, E, Maaheimo, H, Pääkkönen, J, Hakulinen, N, Rouvinen, J, Lähdesmäki, H, Kaski, S, Rousu, J, Penttilä, M & Koivula, A 2020, ' Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods ', Applied Microbiology and Biotechnology, vol. 104, no. 24, pp. 10515-10529 . https://doi.org/10.1007/s00253-020-10960-x
'Applied Microbiology and Biotechnology ', vol: 104, pages: 10515-10529 (2020)
Voutilainen, S, Heinonen, M, Andberg, M, Jokinen, E, Maaheimo, H, Pääkkönen, J, Hakulinen, N, Rouvinen, J, Lähdesmäki, H, Kaski, S, Rousu, J, Penttilä, M & Koivula, A 2020, ' Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods ', Applied Microbiology and Biotechnology, vol. 104, no. 24, pp. 10515-10529 . https://doi.org/10.1007/s00253-020-10960-x
'Applied Microbiology and Biotechnology ', vol: 104, pages: 10515-10529 (2020)
Abstract In this work, deoxyribose-5-phosphate aldolase (Ec DERA, EC 4.1.2.4) from Escherichia coli was chosen as the protein engineering target for improving the substrate preference towards smaller, non-phosphorylated aldehyde donor substrates, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df04bea6ee5917b68fa5f071bc2b647
https://doi.org/10.1007/s00253-020-10960-x
https://doi.org/10.1007/s00253-020-10960-x
Autor:
Miriam Kellock, Anna Borisova, Hannu Maaheimo, Jenni Rahikainen, Ulla Holopainen-Mantila, Marc Borrega, Kaisa Marjamaa, John Ralph, Claus Felby, Kristiina Kruus, Tarja Tamminen
Publikováno v:
Kellock, M, Borisova, A, Maaheimo, H, Rahikainen, J, Holopainen-Mantila, U, Borrega, M, Marjamaa, K, Ralph, J, Felby, C, Kruus, K & Tamminen, T 2022, Potential of a Bio-Based Additive in the Prevention of Lignin-Induced Recalcitrance under Severe Pretreatment Conditions . in A Virtanen, K Torvinen & J Vepsäläinen (eds), NWBC 2022 : The 10th Nordic Wood Biorefinery Conference . VTT Technical Research Centre of Finland, VTT Technology, no. 409, pp. 200-201, 10th Nordic Wood Biorefinery Conference, NWBC 2022, Helsinki, Finland, 25/10/22 . < https://publications.vtt.fi/pdf/technology/2022/T409.pdf >
VTT Technical Research Centre of Finland-PURE
VTT Technical Research Centre of Finland-PURE
Second-generation biorefineries converting lignocellulose to renewable fuels and chemicals require pretreatment to open the cell wall structure and enable enzymes to access polysaccharides. However, lignin from the commonly used hydrothermal pretreat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::243fcc002a66688d7da5f8aa692a01a3
https://cris.vtt.fi/en/publications/9ac7e100-eedd-4aba-95a0-cbd7fa237a3c
https://cris.vtt.fi/en/publications/9ac7e100-eedd-4aba-95a0-cbd7fa237a3c
Autor:
Jenni Rahikainen, Kaisa Marjamaa, Tarja Tamminen, Miriam Kellock, John Ralph, Claus Felby, Heng Zhang, Hannu Maaheimo, Ulla Holopainen-Mantila, Kristiina Kruus
Publikováno v:
Kellock, M, Maaheimo, H, Marjamaa, K, Rahikainen, J, Zhang, H, Holopainen-Mantila, U, Ralph, J, Tamminen, T, Felby, C & Kruus, K 2019, ' Effect of hydrothermal pretreatment severity on lignin inhibition in enzymatic hydrolysis ', Bioresource Technology, vol. 280, pp. 303-312 . https://doi.org/10.1016/j.biortech.2019.02.051
Hydrothermal pretreatment is commonly used for enhancing enzymatic hydrolysis of lignocellulosics. Spruce and wheat straw were pretreated with increasing severity and lignin characteristics were analysed. The effect of enzymatically isolated lignin o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555fcdcb1def584b711e01082fdad973
https://doi.org/10.1016/j.biortech.2019.02.051
https://doi.org/10.1016/j.biortech.2019.02.051
Autor:
Anna, Ylinen, Hannu, Maaheimo, Adina, Anghelescu-Hakala, Merja, Penttilä, Laura, Salusjärvi, Mervi, Toivari
Publikováno v:
Journal of industrial microbiologybiotechnology. 48(5-6)
Polyhydroxyalkanoates (PHAs) provide biodegradable and bio-based alternatives to conventional plastics. Incorporation of 2-hydroxy acid monomers into polymer, in addition to 3-hydroxy acids, offers possibility to tailor the polymer properties. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1f8e0618a596f29263b16873dfc19f5
https://pubmed.ncbi.nlm.nih.gov/33899921
https://pubmed.ncbi.nlm.nih.gov/33899921
Autor:
Jelena, Matović, Juulia, Järvinen, Iris K, Sokka, Surachet, Imlimthan, Jan-Erik, Raitanen, Ahmed, Montaser, Hannu, Maaheimo, Kristiina M, Huttunen, Sirpa, Peräniemi, Anu J, Airaksinen, Mirkka, Sarparanta, Mikael P, Johansson, Jarkko, Rautio, Filip S, Ekholm
Publikováno v:
Molecular pharmaceutics. 18(1)
Boron neutron capture therapy (BNCT) is a noninvasive binary therapeutic modality applicable to the treatment of cancers. While BNCT offers a tumor-targeting selectivity that is difficult to match by other means, the last obstacles preventing the ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ecd79b218a7ceb135859713697f1f690
https://pubmed.ncbi.nlm.nih.gov/33390018
https://pubmed.ncbi.nlm.nih.gov/33390018
Autor:
Jan-Erik Raitanen, Mikael P. Johansson, Juulia Järvinen, Jarkko Rautio, Surachet Imlimthan, Hannu Maaheimo, Anu J. Airaksinen, Sirpa Peräniemi, Jelena Matovic, Ahmed Montaser, Iris Katariina Sokka, Mirkka Sarparanta, Kristiina M. Huttunen, Filip S. Ekholm
Publikováno v:
Matović, J, Järvinen, J, Sokka, I K, Imlimthan, S, Raitanen, J E, Montaser, A, Maaheimo, H, Huttunen, K M, Peräniemi, S, Airaksinen, A J, Sarparanta, M, Johansson, M P, Rautio, J & Ekholm, F S 2021, ' Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT : Chemical Synthesis and in Vitro Evaluation of the Entire Positional Isomer Library of ortho-Carboranylmethyl-Bearing Glucoconjugates ', Molecular Pharmaceutics, vol. 18, no. 1, pp. 285-304 . https://doi.org/10.1021/acs.molpharmaceut.0c00917
Boron neutron capture therapy (BNCT) is a noninvasive binary therapeutic modality applicable to the treatment of cancers. While BNCT offers a tumor-targeting selectivity that is difficult to match by other means, the last obstacles preventing the ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4ebd61d3f900e8c6d0656aebc158ac
http://hdl.handle.net/10138/340053
http://hdl.handle.net/10138/340053