Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Hanns-Christian Mahler"'
Publikováno v:
Journal of Pharmaceutical Sciences. 112:1681-1686
Autor:
Patrick Hughes, Hongwen M. Rivers, Vladimir Bantseev, Chun-Wan Yen, Hanns-Christian Mahler, Swati Gupta
Publikováno v:
Expert Opinion on Drug Delivery. 20:223-240
Autor:
Sonja Peter, Atanas Koulov, Andreas Zerr, Ombeline Danton, Hanns-Christian Mahler, Michael Jahn, Ariane Schröter, Pascal Chalus, Jörg Huwyler
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3410-3417
Leaching of toxic or reactive chemicals from polymeric materials can adversely affect the quality and safety of biopharmaceuticals. It was therefore the aim of the present study to analyze leachables from a disposable clinical administration syringe
Autor:
John D. Ayres, Hanns-Christian Mahler
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3325-3330
The use of in-line filters to remove fibrous material in the administration of intravenous fluids dates to the early 1830’s. Following advancements in therapeutic interventions, high volume fluid support and parenterally administered drugs and biol
Autor:
Ariane Schröter, Hanns-Christian Mahler, Michael Jahn, Atanas Koulov, Jörg Huwyler, Nadia Ben Sayed
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3268-3275
Introduction: The migration of chemicals from processing materials into biopharmaceuticals can lead to various problems. Leachables from administration materials, with no possibility of further clearance, are of particular concern. Released chemicals
Autor:
Dhananjay Jere, Ahmad S. Sediq, Hanns-Christian Mahler, Ilona Vollrath, Jörg Huwyler, Markus Kardorff
Publikováno v:
Journal of Pharmaceutical Sciences. 110:1900-1908
Advanced therapy medicinal products (ATMPs), such as somatic cell-therapy medicinal products or tissue-engineered products for human use, offer new and potentially curative opportunities to treat yet untreatable diseases or disorders. For cell-therap
Autor:
Andrew J. Racher, Roman Mathaes, Joerg Huwyler, Atanas Koulov, Joachim Schuster, Pascal Detampel, Hanns-Christian Mahler, Susanne Joerg
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 152:193-201
In recent years, the stability of biotherapeutics in vivo has received increasing attention. Assessing the stability of biotherapeutics in serum may support the selection of adequate molecule candidates. In our study, we compared the physical stabili
Autor:
Roman Mathaes, Hanns-Christian Mahler, Pascal Detampel, Joerg Huwyler, Joachim Schuster, Susanne Joerg, Atanas Koulov, Kai D. Schleicher
Publikováno v:
Journal of Pharmaceutical Sciences. 109:1827-1832
In recent years, an increasing number of studies assessed the stability of biotherapeutics in biological fluids. Such studies aim to simulate the conditions encountered in the human body and investigate the in vivo stability under in vitro conditions
Publikováno v:
Drying Technologies for Biotechnology and Pharmaceutical Applications
Autor:
Atanas Koulov, Hanns-Christian Mahler, Sarah S. Peláez, Christoph Herdlitschka, Anja Matter, Matthias Kahl, Satish K. Singh, Oliver Germershaus, Toni Wertli, Martina Widmer, Roman Mathaes
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 73:220-234
The sterility of drug products intended for parenteral administration is a critical quality attribute (CQA) because it serves to ensure patient safety, and is thus a key requirement by health authorities. Whilst sterility testing is a probabilistic t