Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Hanns Ulrich, Zeilhofer"'
Publikováno v:
Swiss Medical Weekly, Vol 154, Iss 7 (2024)
AIM OF THE STUDY: The aim of this study is to provide an analysis of the career trajectory of the recipients of a Swiss National MD-PhD grant thirty years after the creation of the Swiss interuniversity MD-PhD programme. METHODS: The study surveyed
Externí odkaz:
https://doaj.org/article/c2a706601d914e3785c3c0b3a2d9e097
Autor:
Olivia C. Davis, Allen C. Dickie, Marami B. Mustapa, Kieran A. Boyle, Tyler J. Browne, Mark A. Gradwell, Kelly M. Smith, Erika Polgár, Andrew M. Bell, Éva Kókai, Masahiko Watanabe, Hendrik Wildner, Hanns Ulrich Zeilhofer, David D. Ginty, Robert J. Callister, Brett A. Graham, Andrew J. Todd, David I. Hughes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Unmyelinated non-peptidergic nociceptors (NP afferents) arborise in lamina II of the spinal cord and receive GABAergic axoaxonic synapses, which mediate presynaptic inhibition. However, until now the source of this axoaxonic synaptic input w
Externí odkaz:
https://doaj.org/article/e1e8b47c69cd415985186a348e491925
Autor:
Noémie Frezel, Matteo Ranucci, Edmund Foster, Hagen Wende, Pawel Pelczar, Raquel Mendes, Robert P. Ganley, Karolina Werynska, Simon d’Aquin, Camilla Beccarini, Carmen Birchmeier, Hanns Ulrich Zeilhofer, Hendrik Wildner
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112295- (2023)
Summary: Corticospinal tract (CST) neurons innervate the deep spinal dorsal horn to sustain chronic neuropathic pain. The majority of neurons targeted by the CST are interneurons expressing the transcription factor c-Maf. Here, we used intersectional
Externí odkaz:
https://doaj.org/article/3678287c78d04086a70b2243254dea6f
Autor:
Robert Philip Ganley, Marilia Magalhaes de Sousa, Kira Werder, Tugce Öztürk, Raquel Mendes, Matteo Ranucci, Hendrik Wildner, Hanns Ulrich Zeilhofer
Publikováno v:
eLife, Vol 12 (2023)
Spinally projecting serotonergic neurons play a key role in controlling pain sensitivity and can either increase or decrease nociception depending on physiological context. It is currently unknown how serotonergic neurons mediate these opposing effec
Externí odkaz:
https://doaj.org/article/4ff23c7f706d407fb198f8d2ab0f17ca
Autor:
Rebecca Rani Das Gupta, Louis Scheurer, Pawel Pelczar, Hendrik Wildner, Hanns Ulrich Zeilhofer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The spinal dorsal horn harbors a sophisticated and heterogeneous network of excitatory and inhibitory neurons that process peripheral signals encoding different sensory modalities. Although it has long been recognized that this network is cr
Externí odkaz:
https://doaj.org/article/7ed2f83328d34b1d85c69a4326b33081
Autor:
Thomas Sartoretti, Robert P. Ganley, Ruiqing Ni, Patrick Freund, Hanns Ulrich Zeilhofer, Jan Klohs
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
In primary tauopathies, the deposition of tau neurofibrillary tangles and threads as well as neurodegenerative changes have been found within the brain and spinal cord. While degenerative changes have been intensively studied in the brain using struc
Externí odkaz:
https://doaj.org/article/c749cdcee4bc4df5b079d1a4c0912a54
Autor:
Teja Wolfgang Groemer, Antoine Triller, Hanns Ulrich Zeilhofer, Kristina Becker, Volker Eulenburg, Cord Michael Becker
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Glycine receptors (GlyRs) are the primary mediators of fast inhibitory transmission in the mammalian spinal cord, where they modulate sensory and motor signaling. Mutations in GlyR genes as well as some other genes underlie the hereditary disorder hy
Externí odkaz:
https://doaj.org/article/166a9f60105b4770a6d2f5f8c02c9876
Autor:
Anaïs Begemann, Mario A. Acuña, Markus Zweier, Marie Vincent, Katharina Steindl, Ruxandra Bachmann-Gagescu, Annette Hackenberg, Lucia Abela, Barbara Plecko, Judith Kroell-Seger, Alessandra Baumer, Kazuhiro Yamakawa, Yushi Inoue, Reza Asadollahi, Heinrich Sticht, Hanns Ulrich Zeilhofer, Anita Rauch
Publikováno v:
Molecular Medicine, Vol 25, Iss 1, Pp 1-15 (2019)
Abstract Background Deleterious variants in the voltage-gated sodium channel type 2 (Nav1.2) lead to a broad spectrum of phenotypes ranging from benign familial neonatal-infantile epilepsy (BFNIE), severe developmental and epileptic encephalopathy (D
Externí odkaz:
https://doaj.org/article/fbf502b38d494e16bcea44feee0b6afb
Autor:
William T. Ralvenius, Elena Neumann, Martina Pagani, Mario A. Acuña, Hendrik Wildner, Dietmar Benke, Nina Fischer, Ana Rostaher, Simon Schwager, Michael Detmar, Katrin Frauenknecht, Adriano Aguzzi, Jed Lee Hubbs, Uwe Rudolph, Claude Favrot, Hanns Ulrich Zeilhofer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Chronic itch affects about 10% of the general population, however current treatments are largely ineffective. Here, the authors show that targeting of inhibitory α2 and α3GABAA receptors reduces itch in mice and in a canine model, suggesting this a
Externí odkaz:
https://doaj.org/article/8993328b421e431ca678a24d0b1b96fb
Autor:
Ronan V. da Silva, Helge C. Johannssen, Matthias T. Wyss, R. Brian Roome, Farin B. Bourojeni, Nicolas Stifani, Ashley P.L. Marsh, Monique M. Ryan, Paul J. Lockhart, Richard J. Leventer, Linda J. Richards, Bernard Rosenblatt, Myriam Srour, Bruno Weber, Hanns Ulrich Zeilhofer, Artur Kania
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1105-1114 (2018)
Summary: Avoidance of environmental dangers depends on nociceptive topognosis, or the ability to localize painful stimuli. This is proposed to rely on somatotopic maps arising from topographically organized point-to-point connections between the body
Externí odkaz:
https://doaj.org/article/a9fcc6fbb25d459785e33a1569d7366c