Clinical response to larotrectinib in adult Philadelphia chromosome–like ALL with cryptic ETV6-NTRK3 rearrangement

Autor: Valentina Nardi, Nora Ku, Matthew J. Frigault, Adrian M. Dubuc, Harrison Kwei Tsai, Philip C. Amrein, Gabriela S. Hobbs, Andrew M. Brunner, Rupa Narayan, Meghan E. Burke, Julia Foster, Paola Dal Cin, Marcela V. Maus, Amir T. Fathi, Hanno Hock

Publikováno v: Blood Advances, Vol 4, Iss 1, Pp 106-111 (2020)

Abstract: Philadelphia chromosome (Ph)–like acute lymphoblastic leukemia (ALL) is a subtype of Ph-negative ALL that molecularly resembles Ph-positive ALL. It shares the adverse prognosis of Ph-positive ALL, but lacks the BCR-ABL1 fusion oncogene. I

Externí odkaz: https://doaj.org/article/7fc7238856444e36b2853dd5b133bf4f

Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1

Autor: Wenjie Mao, Anna C. Salzberg, Motokazu Uchigashima, Yuto Hasegawa, Hanno Hock, Masahiko Watanabe, Schahram Akbarian, Yuka Imamura Kawasawa, Kensuke Futai

Publikováno v: Cell Reports, Vol 23, Iss 11, Pp 3209-3222 (2018)

Summary: Homeostatic synaptic downscaling reduces neuronal excitability by modulating the number of postsynaptic receptors. Histone modifications and the subsequent chromatin remodeling play critical roles in activity-dependent gene expression. Histo

Externí odkaz: https://doaj.org/article/339ce0b4e3054186867719b3a6258c5a

Cognition and mood-related behaviors in L3mbtl1 null mutant mice.

Autor: Erica Y Shen, Yan Jiang, Wenjie Mao, Kensuke Futai, Hanno Hock, Schahram Akbarian

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0121252 (2015)

Alterations in histone lysine methylation and epigenetic regulators of gene expression could play a role in the neurobiology and treatment of patients diagnosed with mood spectrum disorder, including depression and anxiety. Mutations and altered expr

Externí odkaz: https://doaj.org/article/b8b157fa40ac42f19bf3f2922dcd8eab

Ixazomib in addition to chemotherapy for the treatment of acute lymphoblastic leukemia in older adults

Autor: Philip, Amrein, Karen, Ballen, Kristen, Stevenson, Andrew, Brunner, Gabriela, Hobbs, Hanno, Hock, Steven, McAfee, Jenna, Moran, Meghan, Bergeron, Julia, Foster, Christina, Bertoli, Kristin, McGreggor, Molly, Macrea, Meghan, Burke, Tanya, Behnam, Tina, Som, Aura, Ramos, Megan, Vartanian, Jennifer, Lombardi Story, Christine, Connolly, Traci, Blonquist, Donna, Neuberg, Amir, Fathi

Publikováno v: Leukemia & Lymphoma. 63:1428-1435

We sought to assess the safety of adding ixazomib, an oral proteasome inhibitor, to a multi-agent treatment regimen for older adults with acute lymphoblastic leukemia (ALL). Patients 51 to 75 years of age with newly diagnosed ALL were screened. Induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04e1e4dcbaea28e23d903a5a5446652
https://doi.org/10.1080/10428194.2021.2018582

Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies

Autor: Reuben Benjamin, Charlotte Graham, Deborah Yallop, Agnieszka Jozwik, Oana C Mirci-Danicar, Giovanna Lucchini, Danielle Pinner, Nitin Jain, Hagop Kantarjian, Nicolas Boissel, Marcela V Maus, Matthew J Frigault, André Baruchel, Mohamad Mohty, Athos Gianella-Borradori, Florence Binlich, Svetlana Balandraud, Fabien Vitry, Elisabeth Thomas, Anne Philippe, Sylvain Fouliard, Sandra Dupouy, Ibtissam Marchiq, Maria Almena-Carrasco, Nicolas Ferry, Sylvain Arnould, Cyril Konto, Paul Veys, Waseem Qasim, Antonio Pagliuca, Ghulam Mufti, Piers Patten, Shireen Kassam, Stephen Devereux, Majid Kazmi, Kirsty Cuthill, Victoria Potter, Andrea Kuhnl, Victoria Metaxa, Laarni Bonganay, Orla Stewart, Rose Ellard, Lorraine Catt, Jen Lewis, Farzin Farzaneh, Jackie Chappell, Alice Mason, Vicky Chu, Alan Dunlop, Adeel Saleem, Gary Cheung, Helena Munro, Elka Giemza, Oana Ciocarlie, Jan Chu, Persis Amrolia, Kanchan Rao, Robert Chiesa, Juliana Silva, Annette Hill, Maria Finch, Lindsey Young, Harvinder Hara, Sujith Samarasinghe, Anupama Rao, Ajay Vora, Kimberley Gilmour, Christine Rivat, Clare Murphy, Gulrukh Ahsan, Rasha Said Shamsah, Jesmina James, Sarah Inglott, Gary Wright, Stuart Adams, Natalia Izotova, Marina Konopleva, William Wierda, Elias Jabbour, Partow Kebrieai, Emily Jones, Kara McGee, Marcela Maus, Matthew Frigault, Jami Brown, Vesselina Toncheva, Keagan Casey, Hanno Hock, Meaghan A McKeown, Richard Mathews, Thomas Spitzer, Emmanuel Raffoux, Etienne Lengliné, Raphael Itzykson, Florence Rabian, Jérôme Larghero, Isabelle Madelaine, Elie Azoulay, Emmanuelle Clappier, Sophie Caillat-Zucman, Martine Meunier, Karine Celli-Lebras, Marie-Thérèse Tremorin, Karima Yakouben, Françoise Mechinaud-Heloury, Audrey Grain, Aurélia Alimi, Julie Roupret, Delphine Chaillou, Hélène Cavé, Aurelie Caye-Eude, Odile Fenneteau, Elodie Lainey, Jerome Naudin, Eolia Brissot, Remy Dulery, Florent Malard, Clémence Mediavilla, Agnès Bonnin, Anne Vekhoff, Tounes Ledraa, Anne Daguenel-Nguyen

Publikováno v: The Lancet. 396:1885-1894

Summary Background Genome-edited donor-derived allogeneic anti-CD19 chimeric antigen receptor (CAR) T cells offer a novel form of CAR-T-cell product that is available for immediate clinical use, thereby broadening access and applicability. UCART19 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec40a8b13cd2746d839da37388e3ee8
https://doi.org/10.1016/s0140-6736(20)32334-5