Partial hepatectomy accelerates colorectal metastasis by priming an inflammatory premetastatic niche in the liver

Autor: Jost Luenstedt, Fabian Hoping, Reinhild Feuerstein, Bernhard Mauerer, Christopher Berlin, Julian Rapp, Lisa Marx, Wilfried Reichardt, Dominik von Elverfeldt, Dietrich Alexander Ruess, Dorothea Plundrich, Claudia Laessle, Andreas Jud, Hannes Philipp Neeff, Philipp Anton Holzner, Stefan Fichtner-Feigl, Rebecca Kesselring

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundResection of colorectal liver metastasis is the standard of care for patients with Stage IV CRC. Despite undoubtedly improving the overall survival of patients, pHx for colorectal liver metastasis frequently leads to disease recurrence. The

Externí odkaz: https://doaj.org/article/499172be44134767b086b72d003c9d06

Stereotactic body radiotherapy (SBRT) for locally advanced intrahepatic and extrahepatic cholangiocarcinoma

Autor: Eleni Gkika, Lukas Hallauer, Simon Kirste, Sonja Adebahr, Nico Bartl, Hannes Philipp Neeff, Ralph Fritsch, Volker Brass, Ursula Nestle, Anca Ligia Grosu, Thomas Baptist Brunner

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017)

Abstract Background To evaluate the role of ablative radiotherapy doses in the treatment of hilar or intrahepatic cholangiocarcinoma (CCC) using stereotactic body radiotherapy (SBRT). Methods Consecutive patients treated from 2007 to 2016 with CCC we

Externí odkaz: https://doaj.org/article/ab720d59e4144ab39f2adc0847296e07

Endoscopic R1/Rx Resection of T1 Colorectal Cancer-What Next?

Autor: Arthur Schmidt, Hannes Philipp Neeff, Michael Quante

Publikováno v: The American journal of gastroenterology. 117(4)

T1 carcinoma is often not recognized as such, and inappropriate endoscopic resection techniques are selected, resulting in positive (R1) or nonassessable (Rx) resection margins. Full-thickness resection has been proposed as an alternative to completi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cad9ee7e69e617b3042c4d32d2821f
https://pubmed.ncbi.nlm.nih.gov/35029166

Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer

Autor: Bülent Polat, Dagmar Burchert, Werner Hohenberger, Christoph Müller-Leisse, Michael Geißler, Andreas Rosenwald, Elisabeth Rösler, Wolfgang Bank, Kay C. Willborn, Gunther Klautke, Helmut Gnann, Oliver Kölbl, Thomas Brunner, Christian Stroszczynski, Heinrich Wiesinger, Gunnar Folprecht, Ute Küchenmeister, Kirsten Papsdorf, Hagen Flach, Bernd Rosin, Matthias Schwarzbach, Guido Hildebrandt, Ursula Pession, Sanja Schmeck, Richard Viehbahn, Timo Gaiser, Michael Henke, Christof Lamberti, Robert Grützmann, Detlef Imhoff, Michael J. Eble, Peter Bronsert, Wolf O. Bechstein, Thorsten Jacobi, Bernhard Leibl, Elisabeth Germer, Claus Rödel, Wolfgang Wendt, Martin-Leo Hansmann, Jens Freiberg-Richter, Henning Schäfer, Gerhard G. Grabenbauer, Wolff Schmiegel, Peter Kappl, Harold Ortloff, Andrea Tannapfel, Nicolas Moosmann, Christiane Lange, Philipp Manegold, Vittorio Paolucci, Olaf Dirsch, Klaus Kirchhof, Michael Allgäuer, Jan Braess, Markus Zachäus, Irenäus Adamietz, Rainer Fietkau, Michael Ghadimi, Guido Woeste, Hans Jürgen Schlitt, L. Jacobasch, Ulrike Attenberger, Simon Kirste, Ulrich Halm, Godehard Lahmer, Jochen Gaedcke, Andreas Gschwendtner, Michael Flentje, Christine Volkheimer, Andreas Erbesdolber, Philipp Bruners, Jörn Sträter, Stephan Falk, Manfred Dörne, Jörg Olaf Habeck, Ulrich Stölzel, Claus-Henning Köhne, Christoph-Thomas Germer, Lutz Renziehausen, Rolf-Peter Henke, Stefan Post, Ludger Staib, Popiliu Piso, Monika Warmuth-Metz, Volker Kunzmann, Christian Wittekind, Peter Wild, Thomas Kittner, Marga Lang-Welzenbach, Tom Lüdde, Martin Eichel, Dietrich Meißner, Joachim Boese-Land, Marcel Binnebösel, Frank Griesinger, Ruth Knüchel-Clarke, Ralf-Dieter Hofheinz, Eckhardt Schneider, Giovanna Römer, Ulrich Kania, Tim Friede, Klaus Holzweißig, Thorsten Bley, Felix Steger, Stefan Krämer, Anca-Ligia Grosu, Emmanouil Fokas, Michael Pohl, Ernst Klar, Heiko Sülberg, Nils Habbe, Petra Hödl, Andre Serebrennikov, Anke Schlenska-Lange, Thomas Kuhnt, Katica Krajinovic, Ullrich Graeven, Thomas Schmidt, Stephan Sahm, Gustavo Baretton, Ulrike Ubbelohde, Kirsten Merx, Ferdinand Hofstädter, Frederik Wenz, Christian Möllecken, Hannes Philipp Neeff

Publikováno v: JAMA Oncol

Importance Total neoadjuvant therapy has been increasingly adopted for multimodal rectal cancer treatment. The optimal sequence of chemoradiotherapy (CRT) and chemotherapy needs to be established. Objective To report the long-term results of the seco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04cd2e279e369e20381feb63851ae9d
https://doi.org/10.1001/jamaoncol.2021.5445

Outcome after hepatic resection for isolated non-colorectal, non-neuroendocrine liver metastases in 100 patients - the role of the embryologic origin of the primary tumor

Autor: Philipp Anton Holzner, Frank Makowiec, Andrea Klock, Torben Glatz, Stefan Fichtner-Feigl, Sven Arke Lang, Hannes Philipp Neeff

Publikováno v: BMC Surgery
BMC Surgery, Vol 18, Iss 1, Pp 1-9 (2018)

Background The indication for hepatic resection (HR) in patients suffering from liver metastases (LM) other than colorectal and neuroendocrine tumors is one focus of current multidisciplinary, oncologic considerations. This study retrospectively anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::773ce7be1e8a03aa7364133603f4870f
https://pubmed.ncbi.nlm.nih.gov/30373582