Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Hannes Mutschler"'
Periodic temperature changes drive the proliferation of self-replicating RNAs in vesicle populations
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
How primordial cells could achieve inheritance of encapsulated components is still an open question. Here, the authors show that ribozymes can assemble in active forms and replicate in populations of membrane vesicles thanks to freeze-thaw cycles.
Externí odkaz:
https://doaj.org/article/26332a316667461caa46f0aaad9b30f3
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Non-equilibrium conditions at heated water-air interfaces can model Hadean microenvironments. Here, the authors show that such conditions enable one-pot synthesis, strand release and folding of functional RNAs similar to modern biological systems.
Externí odkaz:
https://doaj.org/article/e53d8ebdbac54e838d29499eb57fc1dd
Publikováno v:
eLife, Vol 12 (2023)
Condensed coacervate phases are now understood to be important features of modern cell biology, as well as valuable protocellular models in origin-of-life studies and synthetic biology. In each of these fields, the development of model systems with v
Externí odkaz:
https://doaj.org/article/4855d398eb9a49c08c02741b3f99662d
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Host proteins are identified which are required to reconstitute a functional RNA phage MS2 replication machinery, providing a promising platform for cell-free gene expression.
Externí odkaz:
https://doaj.org/article/9526d7c8514543e0afa2cc47f9e97cfa
Autor:
Carsten Donau, Fabian Späth, Marilyne Sosson, Brigitte A. K. Kriebisch, Fabian Schnitter, Marta Tena-Solsona, Hyun-Seo Kang, Elia Salibi, Michael Sattler, Hannes Mutschler, Job Boekhoven
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Membraneless organelles are liquid-liquid phase-separated droplets whose behaviour can be regulated by chemical reactions, but this process is poorly understood. Here, the authors report model membraneless organelles based on coacervate droplets that
Externí odkaz:
https://doaj.org/article/53f26a477224479ea3212191c3174896
Autor:
Björn Drobot, Juan M. Iglesias-Artola, Kristian Le Vay, Viktoria Mayr, Mrityunjoy Kar, Moritz Kreysing, Hannes Mutschler, T-Y Dora Tang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Phase separation of mixtures of oppositely charged polymers provides a simple and direct route to compartmentalisation via coacervation. Here authors demonstrate that a coacervate microenvironment supports RNA catalysis whilst selectively sequesterin
Externí odkaz:
https://doaj.org/article/ffa9ae58dd1c47ec95dba2093bd693d4
Autor:
Hannes Mutschler, Alexander I Taylor, Benjamin T Porebski, Alice Lightowlers, Gillian Houlihan, Mikhail Abramov, Piet Herdewijn, Philipp Holliger
Publikováno v:
eLife, Vol 7 (2018)
Recombination, the exchange of information between different genetic polymer strands, is of fundamental importance in biology for genome maintenance and genetic diversification and is mediated by dedicated recombinase enzymes. Here, we describe an in
Externí odkaz:
https://doaj.org/article/27b3cb250f45472582dd0345df05c355
Autor:
Thomas Litschel, Kristina A Ganzinger, Torgeir Movinkel, Michael Heymann, Tom Robinson, Hannes Mutschler, Petra Schwille
Publikováno v:
New Journal of Physics, Vol 20, Iss 5, p 055008 (2018)
Early protocells are commonly assumed to consist of an amphiphilic membrane enclosing an RNA-based self-replicating genetic system and a primitive metabolism without protein enzymes. Thus, protocell evolution must have relied on simple physicochemica
Externí odkaz:
https://doaj.org/article/db732912daea4625a84c152872457d92
Publikováno v:
PLoS Biology, Vol 9, Iss 3, p e1001033 (2011)
Most genomes of bacteria contain toxin-antitoxin (TA) systems. These gene systems encode a toxic protein and its cognate antitoxin. Upon antitoxin degradation, the toxin induces cell stasis or death. TA systems have been linked with numerous function
Externí odkaz:
https://doaj.org/article/9d846bdc2b624756ab98bdffe99da69b
Autor:
Jacopo De Capitani, Hannes Mutschler
Publikováno v:
Biochemistry. 62:1221-1232
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4b62ca37ea967a97e891be770bb284c
https://doi.org/10.1021/acs.biochem.3c00023
https://doi.org/10.1021/acs.biochem.3c00023