Výsledky vyhledávání - "Hannes Ludewig"

Akademický článek

Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates

Autor: Clarissa M. Czekster, Hannes Ludewig, Stephen A. McMahon, James H. Naismith

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Cyclic peptide macrocycles are promising anti-cancer and antimicrobial molecules. Here, the authors characterize the structure and catalytic mechanism of the prolyl oligopeptidase B from Basidiomycete fungi, showing that its dual macrocyclase-peptida

Externí odkaz: https://doaj.org/article/6dc005fce7cd4bbe952d36cff3418252

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A marine viral halogenase that iodinates diverse substrates

Autor: Yunpeng Wang, Stephen E. Shanahan, Richard J. K. Taylor, Rebecca J. M. Goss, Danai S. Gkotsi, Jack A. Connolly, Hannes Ludewig, Jagwinder Dhaliwal, Matthew M. W. McLachlan, William P. Unsworth, James H. Naismith, Sunil V. Sharma

We thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007–2013/ERC grant agreement no. 614779 GenoChemetics to R.J.M.G.), Syngenta and Wellcome ISSF (grant no. 204821/Z/16/Z to D.S.G.) for generous fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1f06dd85e509dccd214f98051dc7ff
https://eprints.whiterose.ac.uk/152554/1/Revised_VirX1_210619_1_WPU_edit_AAM.docx

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A marine viral halogenase that iodinates diverse substrates

Autor: Danai S, Gkotsi, Hannes, Ludewig, Sunil V, Sharma, Jack A, Connolly, Jagwinder, Dhaliwal, Yunpeng, Wang, William P, Unsworth, Richard J K, Taylor, Matthew M W, McLachlan, Stephen, Shanahan, James H, Naismith, Rebecca J M, Goss

Publikováno v: Nature chemistry. 11(12)

Oceanic cyanobacteria are the most abundant oxygen-generating phototrophs on our planet and are therefore important to life. These organisms are infected by viruses called cyanophages, which have recently shown to encode metabolic genes that modulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b425222cedf460f772354259d2108588
https://pubmed.ncbi.nlm.nih.gov/31758155

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Characterization of the fast and promiscuous macrocyclase from plant PCY1 enables the use of simple substrates

Autor: Andrew F. Bent, Clarissa M. Czekster, Mohammed Arshad, Hannes Ludewig, Elizabeth S. Munday, James H. Naismith, Silvia Anna Synowsky, Emilia Oueis

Publikováno v: ACS Chemical Biology

H.L. is funded by the George and Stella Lee Scholarship and EPSRC. This project was funded by the European Research Council project 339367 NCB-TNT and by the BBSRC (J.H.N.). E.S.M. and M.A. are funded by EPSRC. S.A.S. is funded by BSRC mass spec faci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480da5e22df29b079738505ea942d778
https://hdl.handle.net/10023/16948

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Structural analysis of leader peptide binding enables leader-free cyanobactin processing

Autor: Marcel Jaspars, Andrew F. Bent, Sally L. Shirran, Tomas Lebl, Jesko Koehnke, Catherine H. Botting, Wael E. Houssen, James H. Naismith, Greg Mann, Hannes Ludewig

Publikováno v: Nature chemical biology

This work was supported by grants from the ERC 339367 (J.H.N. and M.J.) and BBSRC BB/K015508/1 (J.H.N and M.J.). We acknowledge use of the Diamond (beamlines I02 and I24) and ESRF (beamline ID29) synchrotrons. JHN is Royal Society Wolfson Merit Award

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefaa9b22d52106305374ed8da7b60e7
https://hdl.handle.net/10023/10008

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