Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Hannes Leisch"'
Autor:
Kofi Abokitse, Florence Perrin-Sarazin, Christopher R. Corbeil, Hannes Leisch, Stephan Grosse, Peter C. K. Lau
Publikováno v:
Appl Environ Microbiol
The single putative cutinase-encoding gene from the genome of Kineococcus radiotolerans SRS30216 was cloned and expressed in Escherichia coli as a secreted fusion protein, designated YebF-KrCUT, where YebF is the extracellular carrier protein. The 29
Autor:
Peter C. K. Lau, Hélène Bergeron, Miroslaw Cygler, Rong Shi, Stephan Grosse, Hiroaki Iwaki, Hannes Leisch, Krista Morley, Yoshie Hasegawa
Publikováno v:
Applied and Environmental Microbiology. 78:2200-2212
A dimeric Baeyer-Villiger monooxygenase (BVMO) catalyzing the lactonization of 2-oxo-Δ 3 -4,5,5-trimethylcyclopentenylacetyl-coenzyme A (CoA), a key intermediate in the metabolism of camphor by Pseudomonas putida ATCC 17453, had been initially chara
Autor:
David Ilceski, Hannes Leisch, Álvaro T. Omori, Jacqueline Gilmet, Kevin J. Finn, Tomáš Hudlický, Tyler Bissett
Publikováno v:
Tetrahedron. 65:9862-9875
Whole-cell fermentation of β-bromoethylbenzene with the recombinant strain Escherichia coli JM109 (pDTG601) that over-expresses toluene dioxygenase provided the corresponding cis -dihydrodiol 19 , which served as a starting material for both enantio
Publikováno v:
European Journal of Organic Chemistry. 2009:2806-2819
The reaction of the chiral auxiliary version of the Burgess reagent with epoxides yields diastereomeric pairs of sulfamidates, which lead to cis and trans amino alcohols in each enantiomeric series. Experimental and spectral details are provided for
Autor:
Hannes Leisch, Vincenzo De Luca, Tomáš Hudlický, Vigi Chaudhary, Alena Moudra, D. Phillip Cox, Blake Allen
Publikováno v:
Collection of Czechoslovak Chemical Communications. 74:1179-1193
Morphine alkaloids and some of its derivatives (morphine, codeine, thebaine, oripavine, hydrocodone, and oxycodone) were subjected to fermentations with six fungal strains. The alkaloids were transformed to a variety of products via biological oxidat
Publikováno v:
The Journal of Organic Chemistry. 74:747-752
The ethylene glycol ketal of neopinone was prepared in a one-pot procedure by the reaction of thebaine with ethylene glyocol in the presence of p-toluenesulfonic acid. The ketal is also an intermediate in the conversion of thebaine to hydrocodone wit
Publikováno v:
Advanced Synthesis & Catalysis. 350:2984-2992
Hydrocodone was converted to various N-acyl derivatives via a one-pot N-demethylation/N-acylation protocol catalyzed by palladium(II). The procedure has also been successfully applied to several N-methyltropane alkaloids. A plausible mechanism is sug
Publikováno v:
Tetrahedron: Asymmetry. 19:672-681
2-Methylpiperidine and 2-cyclohexylpiperidine were converted to their respective β-keto amides by treatment with diketene. Several strains of yeast were used to reduce the racemic β-keto amides. The unreacted enantiomers were separated from the β-
Publikováno v:
Synlett. 2007:2859-2862
An enzymatically generated diene diol was utilized as homochiral starting material in the total synthesis of (+)-codeine featuring a Mitsunobu inversion and two intramolecular Heck -cyclizations.
Publikováno v:
The Journal of Organic Chemistry. 72:4989-4992
Reaction of the Burgess reagent with a series of aliphatic and aromatic thiols led to the corresponding symmetrical disulfides in high yields. No olefins were detected in the reactions of aliphatic thiols.