Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hannes Hagen"'
Autor:
João M. Fernandes Neto, Ernest Nadal, Evert Bosdriesz, Salo N. Ooft, Lourdes Farre, Chelsea McLean, Sjoerd Klarenbeek, Anouk Jurgens, Hannes Hagen, Liqin Wang, Enriqueta Felip, Alex Martinez-Marti, August Vidal, Emile Voest, Lodewyk F. A. Wessels, Olaf van Tellingen, Alberto Villanueva, René Bernards
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
A drug used at the maximum tolerated dose can exert a strong selective pressure on cancer cells leading to resistance. In this study, the authors demonstrate the efficacy of using low dose of multiple drugs for preventing and treating resistance to E
Externí odkaz:
https://doaj.org/article/fa274e19e6774a2dbd7ad05e9103dbab
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Tumor progression depends primarily on vascular supply, which is facilitated by angiogenic activity within the malignant tissue. Non-small cell lung cancer (NSCLC) is a highly vascularized tumor, and inhibition of angiogenesis was projected to be a p
Externí odkaz:
https://doaj.org/article/cecbe7e439a74571a489382e29dda482
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Tumor progression depends primarily on vascular supply, which is facilitated by angiogenic activity within the malignant tissue. Non-small cell lung cancer (NSCLC) is a highly vascularized tumor, and inhibition of angiogenesis was projected to be a p
Autor:
Emile E. Voest, Olaf van Tellingen, Sjoerd Klarenbeek, Anouk Jurgens, Chelsea M. McLean, Evert Bosdriesz, Ernest Nadal, René Bernards, Enriqueta Felip, August Vidal, Salo N. Ooft, Alex Martinez-Marti, Lourdes Farre, Liqin Wang, Hannes Hagen, João M. Fernandes Neto, Alberto Villanueva, Lodewyk F. A. Wessels
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, 11(1):3157. Nature Publishing Group
Nature Communications
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientia
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Fernandes Neto, J M, Nadal, E, Bosdriesz, E, Ooft, S N, Farre, L, McLean, C, Klarenbeek, S, Jurgens, A, Hagen, H, Wang, L, Felip, E, Martinez-Marti, A, Vidal, A, Voest, E, Wessels, L F A, van Tellingen, O, Villanueva, A & Bernards, R 2020, ' Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours ', Nature Communications, vol. 11, no. 1, 3157, pp. 3157 . https://doi.org/10.1038/s41467-020-16952-9
Universidad de Barcelona
Nature Communications, 11(1):3157. Nature Publishing Group
Nature Communications
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientia
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Fernandes Neto, J M, Nadal, E, Bosdriesz, E, Ooft, S N, Farre, L, McLean, C, Klarenbeek, S, Jurgens, A, Hagen, H, Wang, L, Felip, E, Martinez-Marti, A, Vidal, A, Voest, E, Wessels, L F A, van Tellingen, O, Villanueva, A & Bernards, R 2020, ' Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours ', Nature Communications, vol. 11, no. 1, 3157, pp. 3157 . https://doi.org/10.1038/s41467-020-16952-9
Resistance to targeted cancer drugs is thought to result from selective pressure exerted by a high drug dose. Partial inhibition of multiple components in the same oncogenic signalling pathway may add up to complete pathway inhibition, while decreasi
Autor:
Chelsea M. McLean, Emile E. Voest, Alberto Villanueva, Lodewyk F. A. Wessels, Enriqueta Felip, Lourdes Farre, Sjoerd Klarenbeek, João M. Fernandes Neto, Anouk Jurgens, Alex Martinez-Marti, René Bernards, Liqin Wang, Olaf van Tellingen, Hannes Hagen, Evert Bosdriesz, Salo N. Ooft, Ernest Nadal
Targeted cancer drugs often elicit powerful initial responses, but generally fail to deliver long-term benefit due to the emergence of resistant cells1,2. This is thought to be the consequence of strong selective pressure exerted on the cancer drug t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2bfc178dbeaa6d139b9b2d73e64d19
Publikováno v:
Soil Systems, Vol 8, Iss 2, p 47 (2024)
For large infrastructure projects, such as high-voltage underground cables or for evaluating the very shallow geothermal potential (vSGP) of small-scale horizontal geothermal systems, large-scale geothermal collector systems (LSCs), and fifth generat
Externí odkaz:
https://doaj.org/article/0230d643fb664f8d800e648d83b71142
Publikováno v:
Baños, David Di Nunno, Giulia Haferkorn, Hannes Hagen Proske, Frank Norbert . Stochastic functional differential equations and sensitivity to their initial path. Abel Symposia. 2018, 13, 37-70
Abel Symposia
Abel Symposia
Externí odkaz:
http://hdl.handle.net/10852/67108
https://www.duo.uio.no/bitstream/handle/10852/67108/2/memory-merged-Abel.pdf
https://www.duo.uio.no/bitstream/handle/10852/67108/2/memory-merged-Abel.pdf
Publikováno v:
Computation and Combinatorics in Dynamics, Stochastics and Control ISBN: 9783030015923
We consider systems with memory represented by stochastic functional differential equations. Substantially, these are stochastic differential equations with coefficients depending on the past history of the process itself. Such coefficients are hence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b9009500b7b318e359e0e11d9ec890b
https://doi.org/10.1007/978-3-030-01593-0_2
https://doi.org/10.1007/978-3-030-01593-0_2
Publikováno v:
Applied mathematics and optimization
Time change is a powerful technique for generating noises and providing flexible models. In the framework of time changed Brownian and Poisson random measures we study the existence and uniqueness of a solution to a general mean-field stochastic diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64675a721e98dcefcb6418c0ee8b8dc1
https://hdl.handle.net/11250/2466053
https://hdl.handle.net/11250/2466053